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BACKGROUND OF THE INVENTION
The present invention relates to a liquid filtering device, and more
particularly to a liquid filtering device for filtering out leukocytes and
other components from blood and extracting red cells only to produce
concentrated red cells.
Filtering devices are employed to filter a liquid to obtain a necessary
component from the liquid. In order to achieve satisfactory separation
performance and stabilize liquid processing capability, it is desired that
any clogging of the filter element of the filtering device be minimized.
To effect component transfusion on a patient who needs only red cells, for
example, it is customary to obtain concentrated red cells through a
centrifugal separation process, and the produced concentrated red cells
are administered to the patient. Since the solution containing
concentrated red cells also contains many leukocytes and platelets, it is
not preferable to transfuse this solution to the patient who needs only
red cells.
There has been employed a filtering process for increasing the purity of
concentrated red cells (a red cell preparation) by removing leukocytes and
platelets. The filtering process uses a main filter element for filtering
out leukocytes and platelets and a preliminary filter element which has a
smaller apparent density and a lower filtration resistance than the main
filter element in order to reduce clogging in the main filter element.
One conventional liquid filtering device for producing highly pure red cell
preparations is shown in FIG. 1 of the accompanying drawings. The liquid
filtering device has a housing 2 in the form of a flat plate which defines
a space 4 therein that is centrally divided by a partition plate 6
disposed in the housing 2. The partition plate 6 has a liquid inlet port 8
defined in an upper end thereof, and a liquid outlet port 10 defined in a
lower end thereof. First filter elements 12a, 12b be applied to the
partition plate 6 in sandwiching relation thereto, and second filter
elements 14a, 14b are placed over the first filter elements 12a, 12b,
respectively. The second filter elements 14a, 14b are pressed against the
first filter elements 12a, 12b, respectively, by a plurality of
projections 16 on inner wall surfaces of the housing 2.
The first filter elements 12a, 12b serve as preliminary filter elements for
minimizing clogging in the second filter elements 14a, 14b. Therefore, the
first filter elements 12a, 12b are coarser than the second filter elements
14a, 14b, and are made of nonwoven fabric of polyester, nylon, or the like
which has a smaller apparent density than the second filter elements 14a,
14b.
The second filter elements 14a, 14b have a larger filtration resistance
than the first filter elements 12a, 12b. Preferably, the second filter
elements 14a, 14b are made of a porous material such as of synthetic resin
or a nonwoven fabric of ultrathin fibers. In the conventional filtering
device shown in FIG. 1, however, the first filter elements 12a, 12b and
the second filter elements 14a, 14b are merely pressed against each other
in superposed relation and fixedly positioned in the housing 2. During a
filtering process, a liquid to be filtered, typically blood, may flow
between the pressed regions of the first filter elements 12a, 12b and the
second filter elements 14a, 14b, a phenomenon known as "short pass", and
may directly go unfiltered into the liquid outlet port 10. Thus, the
liquid is not effectively filtered by the second filter elements 14a, 14b.
As a result, the ratio or percentage of removed leukocytes, i.e., the
leukocyte removal ratio, is lowered. When the filtration resistance of the
second filter elements 14a, 14b is increased by clogging, the first filter
elements 12a, 12 b are liable to be separated from the partition 6, and
the liquid which is not filtered at all may be directed toward the liquid
outlet port 10. Consequently, the conventional liquid filtering device has
proven unsatisfactory.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide a liquid filtering
device which is capable of preventing a short pass of a liquid to be
filtered and also preventing filter elements from being separated.
Another object of the present invention is to provide a liquid filtering
device which has filter elements that can maintain a sufficient removal
ratio and reduce clogging therein.
Still another object of the present invention is to provide a liquid
filtering device including a first filter element which is relatively
coarse and a second filter element which has a relatively large filtration
resistance and is disposed in surrounding relation to the first filter
element, the second filter element being mounted on a partition plate in a
liquidtight manner to prevent the first and second filter elements from
being separated from each other and also prevent the first filter element
from being peeled off the partition plate.
Yet another object of the present invention is to provide a liquid
filtering device which is simple in structure, can be manufactured
inexpensively, and has a sufficient liquid filtering capability.
A further object of the present invention is to provide a liquid filtering
device comprising: a housing having a liquid inlet port and a liquid
outlet port; a partition plate fixedly disposed in said housing; a first
filter element disposed in said housing in an upstream position with
respect to a direction in which a liquid to be filtered flows from said
liquid inlet port to said liquid outlet port; and second filter element
disposed in said housing in a downstream position with respect to said
direction, said second filter element being made of a material having a
larger filtration resistance than said first filter element, said second
filter element having an outer peripheral edge fixed directly to said
partition plate in a liquidtight manner in surrounding relation to said
first filter element.
A still further object of the present invention is to provide a liquid
filtering device wherein said housing comprises a frame and a pair of lids
fitted in opposite sides of said frame and closing the frame in a
liquidtight manner, said partition plate being disposed in said frame,
said first and second filter elements being successively superposed on
said partition plate and pressed against said partition plate by said
lids.
A yet further object of the present invention is to provide a liquid
filtering device further comprising a mesh screen interposed between said
first filter element and said partition plate.
A yet still further object of the present invention is to provide a liquid
filtering device wherein said partition plate having a plurality of
vertical rows of protrusions, said first filter element being pressed into
gaps between said protrusions.
Still another object of the present invention is to provide a liquid
filtering device wherein said partition plate has an upwardly convex
portion directed toward said liquid inlet port.
Yet another object of the present invention is to provide a liquid
filtering device wherein said lids have a plurality of elongate liquid
guides on surfaces thereof facing said partition plate.
Yet still another object of the present invention is to provide a liquid
filtering device for separating leukocytes from blood to produce
concentrated red cells.
The above and other objects, features and advantages of the present
invention will become more apparent from the following description when
taken in conjunction with the accompanying drawings in which preferred
embodiments of the present invention are shown by way of illustrative
example.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a vertical cross-sectional view of a conventional liquid
filtering device;
FIG. 2 is a vertical cross-sectional view of a liquid filtering device
according to the present invention;
FIG. 3 is a schematic view showing a blood separation circuit incorporating
the liquid filtering device of the invention;
FIG. 4 is a perspective view of a liquid filtering device according to
another embodiment of the present invention;
FIG. 5 is an exploded perspective view of the liquid filtering device shown
in FIG. 4;
FIG. 6 is a fragmentary vertical cross-sectional view of the liquid
filtering device illustrated in FIGS. 4 and 5;
FIG. 7 is an exploded perspective view of a liquid filtering device in
accordance with still another embodiment of the present invention; and
FIG. 8 is a fragmentary vertical cross-sectional view of the liquid
filtering device shown in FIG. 7.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
FIG. 2 shows a liquid filtering device, generally designated by the
reference numeral 20, according to an embodiment of the present invention.
The liquid filtering device 20 has a housing 22 in the form of a flat plate
assembly which basically comprises a first plate 24a, a second plate 24b,
and a partition plate 26 sandwiched between the first and second plates
24a, 24b. The first and second plates 24a, 24b are symmetrically arranged
and have a plurality of projections 28a, 28b extending from their inner
wall surfaces toward the partition plate 26. The first and second plates
24a, 24b have respective tapered walls 30a, 30b on their lower ends.
The partition plate 26 is made of synthetic resin and has a liquid inlet
port 32 defined in an upper end thereof and extending downwardly. The
partition plate 26 has a central wall 34 of a narrow cross section having
a tapered upper portion 36 directed toward the liquid inlet port 32. The
central wall 34 has opposite wall surfaces recessed from outer side wall
surfaces of the partition plate 26, thus defining recesses 37 in the
partition plate 26. The partition plate 26 also has a transverse passage
38 defined in a lower portion thereof and a liquid or filtrate outlet port
40 defined in a lower end thereof. First and second filter elements 42a,
42b are partly disposed in the recesses 37 in sandwiching relation to the
central wall 34.
The first filter elements 42a, 42b are coarser and have a smaller apparent
density than second filter elements which will be described later on. The
first filter elements 42a, 42b are preferably made of nonwoven fabric of
polyester, nylon, or the like. The first and second filter elements 42a,
42b of such a material project laterally outwardly beyond the outer side
wall surfaces of the partition plate 26.
Second filter elements 44a, 44b are mounted on the partition plate 26 in
surrounding relation to the first filter elements 42a, 42b. The second
filter elements 44a, 44b are bonded to flat surfaces 46a, 46b of the
partition plate 26 by a strong adhesive so that no liquid will leak from
between the partition plate 26 and the second filter elements 44a, 44b. If
possible from a material standpoint, the flat surfaces 46a, 46b of the
partition plate 26 and the second filter elements 44a, 44b may firmly
united together by a high-frequency or ultrasonic fusing process. The
second filter elements 44a, 44b are pressed against the first filter
elements 42a, 42b by the projections 28a, 28b. As a result, the first
filter elements 42a, 42b are pressed against the central wall 34 under a
certain pressure.
The liquid filtering device 20 is basically constructed as described above.
Operation and advantages of the liquid filtering device 20 will be
described below.
The liquid filtering device 20 may be incorporated in a liquid processing
circuit such as a blood separation circuit as shown in FIG. 3 for removing
leukocytes from blood, for example. The blood separation circuit includes
a blood bag 50 for containing blood from which leukocytes are to be
removed and a physiological saline bag 52 for containing a physiological
saline, the bags 50, 52 being positioned above the liquid filtering device
20. The bags 50, 52 have fluid outlets connected to the liquid inlet port
32 of the liquid filtering device 20 through a pair of liquid conduits 58,
60 having clamps 54, 56 respectively thereon.
The blood separation circuit also includes a physiological saline bag 62
for collecting the physiological saline and a blood bag 64 for collecting
the blood from which leukocytes have been removed, the bags 62, 64 being
positioned below the liquid filtering device 20. The bags 62, 64 have
fluid inlets connected to the liquid outlet port 40 of the liquid
filtering device 20 through a pair of liquid conduits 70, 72 having clamps
66, 68 respectively thereon.
A process of separating leukocytes from blood is carried out as follows:
The clamps 56, 66 are opened and the clamps 54, 68 are closed to allow the
physiological saline to flow from the physiological saline bag 52 into the
liquid filtering device 20 to prime the same. The physiological saline
which flows down through the liquid filtering device 20 is collected into
the physiological saline collecting bag 62.
After the liquid filtering device 20 has been primed, the clamps 54, 68 are
closed and the clamps 56, 66 are opened to allow the blood to flow from
the blood bag 50 into the liquid filtering device 20. More specifically,
the blood which has been introduced into the liquid inlet port 32 of the
liquid filtering device 20 is divided by the tapered portion 36 of the
central wall 34 into two flows which are directed toward the first filter
elements 42a, 42b. The blood which has passed through the relatively
coarse first filter elements 42a, 42b reach the second filter elements
44a, 44b by which leukocytes are trapped. Only red cells pass through the
second filter elements 44a, 44b and then flow through the passage 38 into
the liquid outlet port 40. The red cells are then discharged from the
liquid outlet port 40 and collected via the liquid conduit 52 into the
blood bag 64. During this time, since the second filter elements 44a, 44b
are securely fixed to the flat surfaces 46a, 46b of the central wall 34,
the red cells are prevented from leaking out from between the second
filter elements 44a, 44b and the flat surfaces 46a, 46b.
After all the blood has been introduced into the blood bag 64, the clamp 56
is opened again in order to collect any blood remaining in the liquid
filtering device 20. The physiological saline is supplied again into the
liquid filtering device 20 via the clamp 56 to force he remaining blood
out of the liquid filtering device 20 into the blood bag 64.
After the remaining blood has been collected, the clamp 68 is closed, and
the clamp 66 is opened to collect the physiological saline, which was used
to collect the remaining blood, into the physiological saline 62. The
process of separating leukocytes from the blood is now finished.
A comparative experiment was conducted on various inventive examples of the
liquid filtering device 20 of the present invention and various
comparative examples of the conventional liquid filtering device 2 to
determine leukocyte removal ratios and blood processing times. The results
of the comparative experiment are given in Table below.
TABLE
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Leukocyte removal
Blood processing
Inventive example
ratio (%) time (minutes)
1 95.5 5.7
2 96.8 7.7
3 95.9 6.9
4 97.7 5.4
5 95.8 6.3
Average 96.4 6.4
Comparative Leukocyte removal
Blood processing
example ratio (%) time (minutes)
1 75.6 4.5
2 69.8 3.4
3 71.5 7.8
4 67.6 5.7
5 79.3 9.2
Average 72.8 6.1
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In the inventive examples 1 through 5, the first filter elements 42a, 42b
were made of polyester felt having a smaller apparent density than the
second filter elements 44a, 44b. The second filter elements 44a, 44b were
made of a porous synthetic resin material such as polyvinyl formal "Bell
Eater" (transliterated - registered trademark in Japan, manufactured by
Kanebo, Ltd.). The first filter elements 42a, 42b had a smaller filtration
area than the second filter elements 44a, 44b, and the second filter
elements 44a, 44b were ultrasonically fused to the partition plate 26 to
sandwich the first filter elements 42a, 42b.
In the comparative examples 1 through 5, the first and second filter
elements were made of the same materials as those of the inventive
examples 1 through 5. The first and second filter elements had the same
filtration areas, and were pressed against the partition plate 6 as shown
in FIG. 1.
400 ml of blood was filtered under a maximum pressure of 500 mm aq by the
liquid filtering devices according to the inventive examples 1 through 5
and the comparative examples 1 through 5, and leukocyte removal ratios and
blood processing times were measured.
As can be seen from Table above, the leukocyte removal ratios of the tested
liquid filtering devices according to the present invention ranged from
95.6 % to 97.7 %, and their average was 96.4 %. The leukocyte removal
ratios of the conventional liquid filtering devices were scattered in a
wider range and lower than those of the liquid filtering devices of the
invention. The blood processing times of the liquid filtering devices of
the invention were in the range of from 5.4 minutes to 7.7 minutes, and
their average was 6.4 minutes. The blood processing times of the
conventional liquid filtering devices ranged from 3.4 minutes to 9.2
minutes, and their average was 6.1 minutes. The blood processing times of
the conventional liquid filtering devices were not largely different from
those of the inventive liquid filtering devices, but had widely different
leukocyte removal ratios and could not perform stable filtering operation.
FIGS. 4 through 6 illustrate a liquid filtering device according to another
embodiment of the present invention. As shown in FIGS. 4 through 6, the
liquid filtering device 20 includes a housing 100 made of synthetic resin
and comprising a wide frame 102 having a converging lower end, and a pair
of lids 104a, 104b fitted in the frame 102 in spaced-apart relation to
each other. The lids 104a, 104b are secured to the frame 102 in a
liquidtight manner by an ultrasonic or high-frequency fusing process or an
adhesive. The frame 102 has an integral partition plate 106 which divides
the interior of the housing 100 into two chambers which are also defined
by the frame 102 and the lids 104a, 104b.
As shown in FIG. 5, the partition plate 106 has a central portion 108
including an upwardly convex upper portion leaving a space 110 in an upper
portion of the frame 102. The partition plate 106 also has a downwardly
converging lower end in a lower portion of the frame 102, leaving a space
112 between the lower end of the partition plate 106 and the frame 102.
The frame 102 has a cylindrical projection 114 on its top which defines a
liquid inlet port 116 axially therethrough. The frame 106 also has a
cylindrical projection 118 on its bottom which defines a liquid outlet
port 120 axially therethrough. The space 110 communicates with the liquid
inlet port 116, whereas the space 112 communicates with the liquid outlet
port 120.
The partition plate 106 has a plurality of vertical rows of protrusions 122
on each of its side surfaces, defining passages 123 between the
protrusions 122 in a horizontal direction normal to the rows of the
protrusions 122.
First filter elements 126a, 126b are disposed one on each side of the
partition plate 106 in covering relation to the partition plate 106 and
the space 110. Second filter elements 128a, 128b are placed over the
respective first filter elements 126a, 126b. The second filter elements
128a, 128b have ends held against an engaging ridge 130 projecting from a
peripheral edge of the frame 102. The lids 104a, 104b are disposed in the
frame 102 in superposed relation to the second filter elements 128a, 128b,
respectively, thus closing the chambers in the frame 102 completely in a
liquidtight manner. Each of the lids 104a, 104b has a plurality of
vertical elongate guides 131 on an inner surface thereof.
The liquid filtering device 20 thus constructed is preferably employed in
the blood separation system illustrated in FIG. 3 for separating
leukocytes from blood. More specifically, when blood is introduced into
the liquid inlet port 116, the blood first enters the space and then flows
therefrom onto the upwardly convex central portion 108 of the partition
plate 106 by which the blood is divided into horizontally opposite areas
in the frame 102. The blood as it flows downwardly is then directed
vertically by the protrusions 122 and horizontally by the passages 123.
As shown in FIG. 6, the first filter elements 126a, 126b are sufficiently
pressed into the passages 123 and disposed in vertical gaps between the
rows of the passages 123. Therefore, the blood necessarily penetrates the
first filters 126a, 126b, and then enters the second filter elements 128a,
128b. Therefore, leukocyters are removed from the blood by the first
filter elements 126a, 126b and the second filter elements 128a, 128b.
Concentrated red cells which have passed through the second filter
elements 128a, 128b flows along the guides 131 on the lids 104a, 104b into
the space 112, from which the concentrated red cells are discharged via
the filtrate outlet port 120 into the blood bag 64 (FIG. 3).
A liquid filtering device according to still another embodiment of the
present invention will be described with reference to FIGS. 7 and 8. Those
components of the liquid filtering device shown in FIGS. 7 and 8 which are
identical to those of FIGS. 4 through 6 are denoted by identical reference
numerals, and will not be described in detail.
As shown in FIGS. 7 and 8, a pair of mesh screens 150 is disposed in the
frame 102 at positions closest to the partition plate 106. More
specifically, the mesh screens 150 are positioned one on each side of the
partition plate 106, and the first filter elements 126a, 126b, the second
filter elements 128a, 128b, and the lids 104a, 104b are successively
disposed over the mesh screens 150. The mesh screens 150 allow the second
filter elements 128a, 128b to be bonded easily to the frame 102 by a
high-frequency or ultrasonic fusing process. Blood to be filtered can
easily enter the first filter elements 126a, 126b and the second filter
elements 128a, 128b since the blood flows downwardly in different
directions through the mesh openings of the mesh screens 150.
With the present invention, as described above, since the second filter
elements are bonded to the partition plate, blood introduced into the
liquid filtering device from the liquid inlet port is always guided to
enter the second filter elements without any short pass toward the
filtrate outlet port of the device. As a consequence, leukocytes are
effectively removed from the blood to produce desired concentrated red
cells. Stated otherwise, inasmuch as the blood flows successively through
the first filter elements and the second filter elements, unwanted
components are effectively filtered out from the blood by the filter
elements, and the filter elements are less subjected to clogging. Because
the second filter elements are fused or bonded to the partition plate, the
first filter elements are prevented from being peeled off by the second
filter elements. The liquid filtering device provides stable liquid
filtering performance as the filter elements are less liable to clog.
Although certain preferred embodiments have been shown and described, it
should be understood that many changes and modifications may be made
therein without departing from the scope of the appended claims.
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