Ligand compounds useful as extractants of certain metals from solutions. Effective also as promoters of the growth of microorganisms. A process for the preparation of such hexadentate ligands and methods of selective extraction of transition and related metal ions from admixtures with other metals.
There are provided novel compounds useful as selective extractants of metal values from aqueous systems comprising a plurality of such ionic species. There is further provided a process for the production of the novel compounds. The invention also relates to a process of selective metal extraction by means of the novel compounds of the invention.
Pharmaceutical compositions comprising compounds of the formula: R.sup.2 C{CH.sub.2 O(CH.sub.2).sub.n CO[NR.sup.3 CHR(CH.sub.2).sub.m CO].sub.q NOHR.sup.1 }.sub.3, wherein R is hydrogen, alkyl optionally substituted by OR.sup.5, SR.sup.5, NR.sup.5 R.sup.6, COR.sup.6, COOR.sup.6, CONR.sup.5 R.sup.6, --NHC(NR.sup.5 R.sup.6).dbd.NR.sup.7, aryl, aralkyl or heteroaryl; R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, alkyl, aralkyl, aryl, COOR.sup.4, CONHR.sup.4 and CONR.sup.4 R.sup.4 ; R.sup.2 may additionally be alkyl substituted by alkoxy, alkenyloxy or by a group --O--(CH.sub.2).sub.p --COOX or --O--(CH.sub.2).sub.p --CONHX, wherein p is an integer from 1 to 10 and X is alkyl, aralkyl, aryl or heteroaryl; R.sup.4, R.sup.5 and R.sup.6 are hydrogen, alkyl, aralkyl, aryl or heteroaryl; n is 1 or 2, m is 0, 1 or 2 and q is 0 or 1, and when m is 0, the moiety --NR.sup.3 CHR-- may be a pyrrolidine ring, or a pharmaceutically acceptable salt thereof, are useful for removal of iron (III) from mammalian cells and iron (III)-dependent organisms and for treatment of iron (III) overload and disorders caused by iron (III)-dependent pathogenic organisms, such as Plasmodium falciparum that causes malaria.
The present invention provides for enhanced bioremediation of hydrocarbon contaminated soils and waters by treating soil or water with a composition comprising of a metal chelated macrocyclic amido amines or mixtures thereof represented by the structural formula: ##STR1## where R is selected from linear or branched alkanes with 8 to 22 carbons, linear or branched alkenes with 4 to 22 carbon atoms; T.sub.1, T.sub.2 and T.sub.3 are independently selected from ethylene, trimethylene, CH.sub.2 CH.sub.2 (NHCH.sub.2 CH.sub.2).sub.x where x is an integer from 1 to 10; MaQb is a metal compound wherein M is a cation selected from cations of Fe, Co, Ni, Cu, Zn, and Mn; and, Q is an anion selected from nitrate, phosphate anions; and a and b are integers from 1 to 3 necessary to satisfy the valence requirements of M and Q. a phosphorous source, and a diluent.
The present invention provides for enhanced bioremediation of hydrocarbon contaminated soils and waters by treating soil or water with a composition comprising of a metal chelated macrocyclic amido amines or mixtures thereof represented by the structural formula: ##STR1## where R is selected from linear or branched alkanes with 8 to 22 carbons, linear or branched alkenes with 4 to 22 carbon atoms; T.sub.1, T.sub.2 and T.sub.3 are independently selected from ethylene, trimethylene, CH.sub.2 CH.sub.2 (NHCH.sub.2 CH.sub.2).sub.x where x is an integer from 1 to 10; MaQb is a metal compound wherein M is a cation selected from cations of Fe, Co, Ni, Cu, Zn, and Mn; and, Q is an anion selected from nitrate, phosphate anions; and a and b are integers from 1 to 3 necessary to satisfy the valence requirements of M and Q. a phosphorous source, and a diluent.
There are provided novel compounds useful as selective extractants of metal values from aqueous systems comprising a plurality of such ionic species. There is further provided a process for the production of the novel compounds. The invention also relates to a process of selective metal extraction by means of the novel compounds of the invention.
