Method, apparatus, and substance for treating tissue having neoplastic cells

Claims

What is claimed is:

1. A probe for treating a cancerous tumor comprising:

an elongated member sized for and having a distal end tapered for interstitially implanting said elongated member in said cancerous tumor;

a heater element positioned about said distal end for producing heat; and

a coating layer joined with said member about said distal end and responsive to said heat for releasing at a predetermined temperature above a temperature of said tumor a drug for providing a treatment of said tumor.

2. The probe of claim 1 wherein said coating layer includes said drug.

3. The probe of claim 1 wherein said coating layer comprises a substance responsive at said predetermined temperature for releasing said drug.

4. A probe for treating tissue having neoplastic ells comprising:

an elongated member having a distal end tapered for interstitially implanting said member in said tissue;

a carrier joined with an outer layer of said member about said distal end and responsive to said tissue for releasing a drug for treating said neoplastic cells; and

a heater element positioned about said distal end for thermally conducting heat to further treat said neoplastic cells.

5. The probe of claim 4 further comprising said drug.

6. The probe of claim 4 further comprising a sensor having an electrical characteristic that changes in response to changes in temperature for measuring a temperature of said probe.

7. The probe of claim 4 wherein said elongated member comprises a semi-rigid thermally conductive material for distributing said heat across said outer layer in a predetermined manner.

8. The probe of claim 4 wherein said carrier comprises a substance for adhering to said outer layer and responsive to said tissue for releasing said drug over a predetermined period of time to said tissue.

9. A method of treating tissue having neoplastic cells with a probe having an elongated member including an outer layer for releasing a drug and a heater element for heating said elongated member, comprising the steps of:

interstitially implanting said elongated member in said tissue;

releasing said drug from said outer layer to said tissue when said member is interstitially implanted in said tissue, said drug for providing a treatment of said neoplastic cells;

energizing said heater element for producing said heat; and

heating said tissue to a first predetermined temperature in response to said heat for providing a second treatment of said neoplastic cells.

10. The method of claim 9 wherein said drug treatment of said neoplastic cells has a first predetermined effectiveness level and said method further comprises heating said drug to a second predetermined temperature in response to said heat for increasing the effectiveness level of said drug treatment to a second predetermined level greater than said first level.

11. The method of claim 9 wherein said probe further includes a sensor for measuring the temperature of said member and wherein said method further comprises measuring the temperature of said member.

12. A method of treating tissue with a probe having an elongated member including an outer layer responsive at a predetermined temperature above a tissue temperature for releasing a substance and also having a heater element for heating said elongated member; comprising the steps of:

interstitially implanting said elongated member in said tissue;

heating said outer layer of said elongated member to said predetermined temperature above a temperature of said tissue; and

releasing from said outer layer at said predetermined temperature said substance interstitially to said tissue, said substance for providing a treatment of said tissue.

13. The method of claim 12 further comprising heating said tissue to a second predetermined temperature with said elongated member for providing a second treatment of said tissue.

14. The method of claim 13 further comprising measuring the temperature of said elongated member for maintaining said tissue at said second predetermined temperature.

15. Apparatus for treating tissue comprising:

an elongated member having a coating, said coating comprising a carrier substance responsive at a predetermined temperature above a temperature of said tissue for releasing a carried substance interstitially to a tissue, said elongated member sized for and having an end tapered for interstitially implanting said elongated member in said tissue; and

said elongated member including therein a heater element for heating said carrier substance to said predetermined temperature above said tissue temperature.

16. The apparatus of claim 15 wherein said elongated member further includes a sensor for measuring the temperature of said elongated member.

17. The apparatus of claim 16 further comprising said carried substance.

18. Apparatus for treating tissue having cancerous cells comprising:

an elongated member having a distal end for interstitially implanting said member in said tissue;

carrier means joined with said member about said distal end and responsive at a first predetermined temperature above a second tissue temperature for releasing a drug interstitially to said tissue, said drug for providing a treatment of said cancerous cells; and

means for heating said carrier means to said first predetermined temperature.

19. The apparatus of claim 18 wherein said means for heating comprises an electrical heater element positioned within said elongated member.

20. The apparatus of claim 18 wherein said elongated member comprises a semi-rigid conductive material for heating said carrier means in a predetermined manner.

21. The apparatus of claim 18 further comprising sensor means positioned within said elongated member for measuring temperature.

22. The apparatus of claim 21 further comprising means for measuring power delivered to said means for heating.

23. The apparatus of claim 22 further comprising said drug.

24. The apparatus of claim 18 wherein said carrier means comprises a carrier substance responsive at said first temperature above said tissue temperature for releasing said drug interstitially to said tissue.

25. The apparatus of claim 24 wherein said carrier substance includes at least one type of molecule selected from the group consisting of polypeptide-, protein-, and carbohydrate chain-based molecules.

26. The apparatus of claim 24 wherein said carrier substance includes at least one type of molecule selected from the group consisting of carbohydrate-, protein-, nucleotide-, and fatty acid-based molecules.

27. The apparatus of claim 24 wherein said carrier substance includes molecules for attaching to molecules of said elongated member and also for attaching to molecules of said drug.

28. The apparatus of claim 24 wherein said carrier substance includes molecules for encapsulating molecules of said drug.

29. The apparatus of claim 28 wherein said molecules of said carrier substance for encapsulating said molecules of said drug includes a surface for adhering to a surface of said elongated member.

30. The apparatus of claim 24 wherein said drug includes molecules for adhering to a surface of said member and wherein said carrier substance comprises a micropore membrane surrounding said drug for diffusing said drug into said tissue.

31. The apparatus of claim 24 wherein said elongated member includes a surface having a port therein; wherein said carrier substance comprises a micropore membrane for surrounding said surface of said elongated member having said port therein; and wherein said drug is injected through said port between said micropore membrane and said member surface.

32. The apparatus of claim 24 wherein said carrier substance includes a chain of fatty acid molecules.

33. An elongated member for use with tissue treatment apparatus and serving to provide a first modality, said first modality for providing a first treatment of tissue, and said member also serving to provide at least one additional modality for providing further treatment of said tissue, characterized in that said member is sized and has a distal end for insertion interstitially in said tissue and that said modalities are provided concomitantly and are arranged so that said additional modality is activated by said first modality.

34. A member according to cla