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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to improvements in instruments and methods
for performing near infrared quantitative analysis to determine percent
fat in a body.
2. Description of the Background Art
It has long been known that obesity reduces longevity, and recent studies
have demonstrated that high percentage of body fat is an independent
health risk factor as a cause of heart attack, stroke, diabetes and other
disabling diseases. (Stokes et al, Metabolic Complications of Human
Obesities; Elsevier Science Publishers, B.V. (Biomedical Division); J.
Vague et al, eds.; pp. 49-57 [1985]).
For the above reasons, several techniques have been developed to determine
percent body fat, including recent techniques based on U.S.A. research
that demonstrates that "near-infrared light interactance" can provide the
basis for measurement of percent body fat (Conway et al, The American
Journal of Clinical Nutrition 40:1123-1130 [1984]).
Near-infrared light interactance technology disclosed in U.S. Pat. No.
4,633,087 to Rosenthal et al has recently been utilized in a commercial
instrument for measurement of body composition, i.e., percent fat in the
human body. However, because of the cost required to manufacture an
instrument that utilizes this technology, the majority of purchasers are
health clubs, medical centers and sports teams, with only a very small
percentage of buyers being individual consumers.
Taking full advantage of the technology disclosed in U.S. Pat. No.
4,633,087 requires the measurement of more than one wavelength in the
near-infrared spectrum. The reason for this is that what is being measured
is the change in slope of the absorption curve, with the slope being
defined as the difference in optical absorption at two defined
wavelengths.
For the following reasons, the cost of utilizing the technology described
in U.S. Pat. No. 4,633,087 remains high even when utilizing inexpensive
infrared emitting diodes (IREDs) as the near-infrared source:
(1) The use of two IREDs are preferred for each of two wavelengths being
measured, and the more IREDs that are used, the greater the expense.
(2) An electronic means for turning on and off each pair of IREDs in a
sequential fashion and keeping them on for a predetermined length of time
is required.
(3) Circuitry is required that allows the output of the pairs of IREDs to
be adjusted so that they have equal energies when measuring a neutral
sample.
(4) Computation circuitry is required that must not only discriminate
between two pairs of IREDs, but also perform a multiple regression
calculation.
(5) Instrument display capability is required that has the ability to
read-out each of the two pairs of IREDs well as the final percent fat.
(6) The instrument must also have the ability of entering a multiple number
of constants because of the multi-term linear regression equation
utilized.
In addition to each of the items discussed above, a major element in the
production cost of current near-infrared analysis instruments is the need
to calibrate each production unit against a series of known samples via
multiple linear regression analyses. These calibration steps are labor
intensive and their elimination would enable great reductions in the cost
of producing such instruments.
In view of the costs required in providing known devices for measuring body
fat content, there remains a need in the art for improved and less
expensive devices for measuring percent body fat.
SUMMARY OF THE INVENTION
In accordance with the present invention, a method for determining percent
fat in a body comprises placing a point source of near-infrared radiation
against a body, transmitting near-infrared radiation into the body,
detecting near-infrared radiation which interacted with the body and
providing a readout, based on near-infrared absorption by the body during
interactance, indicative of body fat content. Placing the point source
against the body eliminates the need for the light-diffusing probes of the
prior art.
The invention further related to apparatus for quantitatively measuring fat
content of a body comprising at least one point source means of
near-infrared radiation, a near-infrared detector capable of providing an
electrical signal upon detection of near-infrared radiation, and means for
placing the point source means against the body so as to introduce
near-infrared radiation for absorption measurement. Data on a plurality of
physical parameters, especially height and weight, may be utilized along
with the measured absorption to quantitatively determine fat content.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a sectional, partially schematic view of an instrument according
to an embodiment of the present invention.
FIG. 2 is a sectional, partially schematic view of the instrument of FIG. 1
in combination with a calibration sleeve.
FIG. 3 is a plot of linear voltage output from an optical detector versus
percent body fat of a subject.
FIG. 4 is a plot of linear voltage output from an optical detector versus
energy received from an IRED point source.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
The invention provides method and apparatus for determining percent body
fat utilizing optical interactance principles in the near-infrared
radiation wavelength range of from about 740 to about 1100 nanometers.
Because of the relationship between optical density (O.D.) and percent
body fat, O.D. measurement of a single bandwidth of near-infrared
radiation can be utilized to provide a high correlation with percent body
fat.
Optical density ordinarily is defined as log 1/I, wherein I is interactance
and equal to E.sub.S /E.sub.r (E.sub.s =energy received from subject;
E.sub.r =energy received from a reference). An important aspect of the
present invention is the substitution of much simpler 1/I mathematics for
the conventional log (1/I) mathematics. When taking a measurement halfway
between the shoulder and elbow on the biceps of a person's prominent arm
(the one used for writing), the local amount of fat measured is directly
proportional to the total fat in the body. With the present invention, a
single bandwidth measurement can provide meaningful measurement of percent
total body fat. A single bandwidth is able to provide this measurement
since the higher the percent body fat, the more transparent the arm of the
subject. This is because low body fat people have "hard muscles" that make
it difficult for light to penetrate, therefore providing high O.D. values.
Conversely, people with high percent body fat have a "flabby" biceps that
is not very optically dense, resulting in low O.D. values.
Although there is no need to be particularly specific in the bandwidth of
interest that the IRED emits, so long as it is within the near-infrared
spectrum, the larger the half-power bandwidth of the light source, within
reason, the better the measurement, since less interference from other
body parameters occurs. Thus, the use of a conventional 950 nanometer IRED
as the illumination source is almost ideal. Such infrared-emitting diodes
have half-power bandwidths of almost 60 nanometers, which make them
practically immune to other types of absorptions (e.g., absorption due to
moisture, protein, etc.).
This invention utilizes the principal of interactance, which principle is
known in the art and differs from reflectance and transmittance. In
interactance, light from a source is shielded by an opaque member from a
detector and interactance of the light with the test subject is then
detected by the detector.
Since the present invention measures radiation of only a single near-IR
bandwidth (which may be emitted from only a single IRED), there is no need
for the instrument to cycle on and off, as is required when utilizing
multiple bandwidth measurements. Thus, there is no need for the inclusion
of a timing circuitry nor IRED cycling circuitry, as is provided in a
multiple bandwidth instrument.
An instrument in accordance with a preferred embodiment of the invention is
illustrated in FIG. 1. In this embodiment, a light transmitting and
diffusing member as taught in connection with many prior devices is not
needed. Instead, at least one and preferably a pair of IREDs and an
optical detector are positioned within the instrument for placement
directly adjacent to the skin of the subject, with substantially no loss
of fat measuring accuracy.
The instrument 50 is dimensioned for hand-held operation and includes a
case 55 housing one or more IREDs 16", a pair of which are shown in
opposite sides of the lower portion thereof. When more than one IRED is
employed, they should be of about the same bandwidth and center frequency
output. The IREDs are disposed opposite window openings 56 in a bottom
surface 57 of the case 55. The windows 56 may further include
near-infrared-transparent coverings (not shown) to prevent the entry of
dust and dirt into the instrument.
An optical detector 28', also positioned in the lower portion of the case
55, is substantially equidistant from each IRED 16". The detector 28" is
disposed within a window opening 59 which, like the windows for the IREDs,
may include a covering transparent to near-IR radiation. If desired, the
window covering over detector 28" can be electronically conductive to
provide EMI shielding. Light baffles 60 are placed between each IRED 16"
and the detector 28 to prevent erroneous readings caused by direct
impingement of near-IR radiation onto the detector. The baffles 60 are
constructed of any opaque and preferably lightweight material. Erroneous
readings also are prevented by the provision of a flexible light shield 74
which blocks ambient light from impinging upon the detector.
The detector 28' and each of the IREDs 16" are mounted within the case 55
on a printed circuit (PC) board 58 which also serves as a carrier for the
remainder of the electronic components.
The optical detector 28' is connected to the input of an electrical signal
amplifier 30' which in turns feeds the amplified signal to an
analog-to-digital (A/D) converter 40'. The A/D converter is connected to a
digital processor 41' which is connected to a readout box 36' (e.g.,
liquid crystal display). In a preferred embodiment the A/D converter,
microprocessor and liquid crystal display driver circuitry are combined
within a single chip (illustrated with dashed lines in FIG. 1) such as the
.mu.PD75328 chip available from NEC Electronics, Inc. The use of this
single chip, which employs a 4-bit microprocessor with 8-bit A/D
circuitry, with no loss of accuracy, greatly reduces the cost of
production units. The linear voltage output (V) from detector 28' is data
processed into a signal indicative of percent body fat which is then
displayed on the readout box.
FIG. 2 illustrates use of an optical standard sleeve for "zero adjust" of
the instrument by the user just before making readings. The standard is a
near-infrared-opaque body or sleeve 70 having a cavity 162 and an internal
flange 164 for cooperating with the end 165 of instrument 50. The
dimensions are chosen such that the tip 166 of instrument 50 will be a
predetermined distance (h) from the bottom portion of cavity 162. This
distance is chosen to provide a reflectance value that corresponds to an
interactance calibration value (%.sub.REF) for which the instrument is
being calibrated (which is the function of the material's reflection
properties and the geometry of the cavity). The standard reflects
sufficient near-infrared radiation emitted from the near-infrared source
in the probe to the near-infrared detectors present therein for "zeroing"
or standardizing the probe for use in an interactance (measurement) mode.
The sleeve 70 includes a reflective surface 72 (which reflects a known
amount of near-IR radiation and, preferably reflects an amount of near-IR
radiation which is substantially equal to the amount of near-IR radiation
transmitted during near-IR interactance from a body of approximately 24%
body fat content) at the standard distance (h) from the IREDs and
detectors.
At the factory, a single "master unit" is calibrated using linear
regression techniques in the conventional manner against a number of
samples of known fat content (i.e., samples previously analyzed via
another universally accepted technique such as underwater weighing). This
calibration procedure provides values for the slope (hereinafter "C.sub.1
") and y-intercept (hereinafter "C.sub.o ") of the linear
fat-determination equation which is used in the master and programmed into
each production unit. In producing production units which are calibrated
based upon the calibration of a single master unit, the following
assumptions are made:
(1) The response of all of the linear detectors is linear with respect to
light level, and zero voltage is output when light level is zero (see FIG.
4). Each detector has a different sensitivity (i.e. line slope), however,
and this sensitivity can change as the detector ages. Thus, a zero adjust
step, to calculate the detector line slope and store the value for use
during interactance measurement, is to be performed by the user just prior
to taking a measurement.
(2) The only difference from instrument to instrument is the difference in
detector voltage output. This difference can be caused by differences in
IRED energy, detector sensitivity, or power supply changes. There is no
difference between units due to spectrum characteristics (because the IRED
bandwidth is wide) or due to dimension changes.
(3) All optical standard sleeves provide identical reflective surfaces so
that all sleeves will read the same value (within a few tenths of a
percent) on a single instrument.
Following calibration against the known samples, the master unit is fitted
with the optical standard sleeve and placed in the zero adjust mode. The
readout will display the percent fat value associated with the optical
standard according to the formula:
%.sub.REF =C.sub.o +C.sub.1 *V.sub.M (I)
where V.sub.M is the linear voltage output from the detector and C.sub.o
and C.sub.1 are intercept and detector line slope output values,
respectively, known from the calibration of the master unit against the
known samples. In order for a production unit to provide the same
%.sub.REF when the optical standard is measured in zero adjust mode, the
following equation must be true:
%.sub.REF =K.sub.o K.sub.1 *V.sub.P (II)
where K.sub.o is an intercept value and K.sub.1 is a detector line slope
value as seen in FIG. 3. From FIG. 4 and equations I and II the following
must be true:
when J.sub.M =0, %=C.sub.o (master unit) (III)
when J.sub.P =0, % =K.sub.o (production unit) (IV)
where J is voltage output from the respective detector. As it is desired to
have the production units have the same calibration as the master unit,
they also must read the same when their detectors output zero voltage.
Thus, from (III) and (IV) above:
C.sub.o =K.sub.o (V)
Thus, equation (II) becomes:
%.sub.REF =C.sub.o K.sub.1 *V.sub.P (VI)
Final zeroing of the production unit is to ensure that the unit behaves as
closely as possible to the master unit and is carried out by the user in
the following manner: The instrument 50 is put in "zero adjust mode" and
is positioned within the standard sleeve 70 such that the tip 166 of the
instrument 50 is spaced away from the bottom portion of cavity 162 so as
to reflect sufficient near-infrared radiation emitted from the tip 166
back to the detector for calibrating the instrument for use in an
interactance mode. When "zero adjust" is pressed on the production unit,
the unit calculates K.sub.1 from (VI) above and stores the K.sub.1 value
to use when measuring a person.
With only a single bandwidth measurement, a simple slope/bias computation
is all that is required to directly determine percent fat. Thus when
measuring a person, the equation is:
%=C.sub.o (%.sub.REF -C.sub.o).div.V.sub.P *V.sub.SUBJ
where C.sub.o, V.sub.P and %.sub.REF are known from above, V.sub.SUBJ is
the linear output from the detector when measuring the subject person and
% is the person's body fat composition.
The material of the optical standard is chosen so that the reflectance
characteristics makes it a usable standard for the constituent being
measured, such as using polyvinyl chloride (PVC) for the calibration cup
as a standard for fat and other types of measurements.
In operation, following calibration, the lower surface of the instrument is
placed against the body for interactance measurement. Measurements of
greatest accuracy are obtained when the instrument is placed against the
biceps and oriented so that the line bisecting the IREDs runs
perpendicular to the axis of the arm.
Elimination of the (log 1/I) calculation in favor of the disclosed 1/I
based calculation has been shown to result in substantially no loss of
accuracy in these interactance measurements. This is because the percent
body fat function itself is essentially linear within the measured ranges.
Calculations based on this linear function can advantageously be performed
with lower cost data processing circuitry than that employed with
logarithmic function calculations.
The elimination of costly factory calibration of each production unit in
favor of user calibration via the simple zero adjust procedure taught
herein also contributes to the lower cost of this preferred embodiment.
As noted above, the single measurement can be made using an IRED at almost
any near-infrared center wavelength. However, people of African origin
have flesh pigments that absorb light from the visible portion of the
spectrum through the very near-infrared spectrum, disappearing at about
950 nanometers. Thus, the commercially available low-cost IREDs which
provide a bandwidth output centering on 950 nanometers are practically
ideal, since they avoid a substantial effect in the measurement based on
skin color.
To provide even more accurate determination of percent body fat, data on a
plurality of physical parameters of the body can be utilized along with
the measured absorption of near-infrared radiation, to quantitatively
determine the fat content of a body. Such physical parameters include, but
are not limited to height, weight, exercise level, sex, race, waste-to-hip
measurement, and arm circumference. When utilizing data on height and
weight parameters in conjunction with measurement of near-infrared
absorption in a single bandwidth measurement, a suitable equation is as
follows:
##EQU1##
where values K.sub.2 and K.sub.3 are determined for the master unit by
multiple linear regression analyses of known subjects as before, W is the
subject's weight in pounds and height is his or her height in inches.
Other parameters are similarly factored into the above equation.
The present invention provides a method and means for accurately and
reliably measuring percent body fat, that is substantially less expensive
than with previously known technology, and in a non-destructive manner,
using near-infrared radiation interactance principles.
Since many modifications, variations and changes in detail may be made to
the described embodiments, it is intended that all matter in the foregoing
description and shown in the accompanying drawings be interpreted as
illustrative and not in a limiting sense.
* * * * *
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