February 12, 1991

This invention provides trans-3,4 1-substituted-3-substituted-4-methyl-4-(3-substituted phenyl)piperidines as opioid antagonists capable of blocking the mu or kappa receptors in the brain.

26

February 12, 1991

07/448,800

December 11, 1989

514/315  

C07D   211/00   (20060101)   C07D   211/22   (20060101)   C07D   409/06   (20060101)   C07D   409/00   (20060101)  

This application is a division, of application Ser. No. 07/284,504, filed 12/14/88, now U.S. Pat. No. 4,891,379, which is a continuation of Ser. No. 07/039,121, filed Apr. 16, 1987, now abandoned.

514/315  

	5136040 - Preparation of substituted tetrahydropyridines - Owned by Eli Lilly and Company (Indianapolis, IN) A process for preparing certain 1,3,4,4-tetrasubstituted-1,2,3,4-tetrahydropyridines is provided as well as certain 4-carbonate-1,3,4-trisubstituted-piperidines.
	5498718 - Preparation of substituted tetrahydropyridines - Owned by Eli Lilly and Company (Indianapolis, IN) A process for preparing certain 1,3,4,4-tetrasubstituted-1,2,3,4-tetrahydropyridines is provided as well as certain 4-carbonate-1,3,4-trisubstituted piperidines.
	5270328 - Peripherally selective piperidine opioid antagonists - Owned by Eli Lilly and Company (Indianapolis, IN) N-alkylamino-3,4,4-substituted piperidines are provided which are useful as peripheral opioid antagonists.
	5159081 - Intermediates of peripherally selective N-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists - Owned by Eli Lilly and Company (Indianapolis, IN) Intermediates of N-carbonyl-3,4,4-substituted piperidines are provided which are useful in the preparation of peripheral opioid antagonists.
	5250542 - Peripherally selective piperidine carboxylate opioid antagonists - Owned by Eli Lilly and Company (Indianapolis, IN) 3,4,4-trisubstitutedpiperidinyl-N-alkylcarboxylates and intermediates for their preparation are provided. These piperidine-N-alkylcarboxylates are useful as peripheral opioid antagonists.