The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, particularly for treatment of allograft rejection, especially including cardiac allograft rejection, pancreatic allograft rejection and renal allograft rejection, and for treating autoimmune diabetes. ##STR1##
CROSS-REFERENCE TO RELATED APPLICATIONS
This is a division of pending application Ser. No. 373,413, filed June 29, 1989, U.S. Pat. No. 4,948,793; which in turn is a division of Ser. No. 233,200, filed Aug. 17, 1988, now U.S. Pat. No. 4,868,153; which is a division of Ser. No. 146,883, filed Jan. 22, 1988, now U.S. Pat. No. 4,786,637; which is a continuation-in-part of Ser. No. 008,717, filed Jan. 30, 1987, now U.S. Pat. No. 4,753,935, all incorporated herein by reference. Ser. No. 373,413 is also a division of application Ser. No. 272,161, filed Nov. 14, 1988, filed Sept. 4, 1987, now U.S. Pat. No. 4,808,592; which is a division of Ser. No. 008,717, filed Jan. 30, 1987, now U.S. Pat. No. 4,753,935, all incorporated herein by reference.
The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
The disclosed hexenoic acid side-chain derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil, including immune, inflammatory, tumor, proliferative, viral or psoriatic disorders.
The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
The disclosed 6-substituted derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil.
