A pharmaceutical aqueous solution for ophthalmic use comprising a nonsteroidal anti-inflammatory drug, having a carboxylic group, a decongestant drug and a mixture of a polysorbate and a poloxamer.

A non-steroidal analgesic anti-inflammatory adhesive preparation rendered by coating one surface of support with an adhesive containing S-(+)-2-(2-fluoro-4-biphenylyl)propionic acid and a styrene-isoprene-styrene block copolymer or S-(+)-2-(2-fluoro-4-biphenylyl)propionic acid and a modified copolymer in which methylmethacrylate is allowed to graft-polymerize on said copolymer, or with an adhesive containing S-(+)-2-(2-fluoro-4-biphenylyl) propionic acid, sodium carboxymethyl cellulose and sodium polyacrylate.

A method of reducing bone loss and promoting bone regrowth, once loss has occurred, particularly alveolar bone loss associated wtih periodontal disease, and a composition useful in the method. The method comprises applying to buccal membranes a therapeutically effective quantity of at least one S enantiomer, generally an S(+) enantiomer, of a nonsteroidal anti-inflammatory drug, such as S(+) flurbiprofen or S(+) ketoprofen. The composition is a formulation which is a toothpaste or which is a mouthwash.

The topical use of certain flurbiprofen amide derivatives and ketorolac amide derivatives to treat ophthalmic angiogenesis-related and inflammatory disorders of the posterior segment of the eye is disclosed.