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High performance microcapillary gel electrophoresis    
United States Patent4997537   
Link to this pagehttp://www.wikipatents.com/4997537.html
Inventor(s)Karger; Barry L. (Newton, MA); Cohen; Aharon (Brookline, MA)
AbstractA microcapillary column for high performance electrophoresis. A preferred column includes a microcapillary, a thin layer of coating material covalently bonded to the inner surface of the microcapillary wall, a thin layer of a hydrophilic polymer absorbed on the layer of coating material, and a gel comprising polyacrylamide polymerized in the tube, filling it. The gel-containing microcapillary is prepared by covalently bonding a layer of a suitable coating material to the inner surface of the microcapillary wall, applying a layer of hydrophilic polymer, and then causing a mixture of monomer with or without crosslinking agent, initiator, and polymerization catalyst to react in the bore of the microcapillary to form a polymeric matrix. In electrophoresis, the gel-containing microcapillary provides peak efficiencies in excess of 100,000 theoretical plates and in some instances over 1,000,000 theoretical plates within separation times of less than thirty minutes, permits trace level determinations of molecular weights, and permits electrophoretic operation at fields of 300 V/cm or higher, resulting in extremely high resolution separations.
   














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Drawing from US Patent 4997537
High performance microcapillary gel electrophoresis - US Patent 4997537 Drawing
High performance microcapillary gel electrophoresis
Inventor     Karger; Barry L. (Newton, MA); Cohen; Aharon (Brookline, MA)
Owner/Assignee     Northeastern University (Boston, MA)
Patent assignment
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Publication Date     March 5, 1991
Application Number     07/406,080
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     September 12, 1989
US Classification     204/453 204/455 204/605
Int'l Classification     G01N 027/26 G01N 027/28 B01D 057/02
Examiner     Niebling; John F.
Assistant Examiner     Starsiak Jr.; John S.
Attorney/Law Firm     Weingarten, Schurgin, Gagnebin & Hayes
Address
Parent Case     CROSS-REFERENCE TO RELATED APPLICATIONS This is a continuation-in-part of application Ser. No. 07/359,728, filed May 31, 1989, pending, which is hereby incorporated by reference. Application Ser. No. 07/359,728 is a continuation of parent application Ser. No. 06/921,311, filed October 21, 1986, now U.S. Pat. No. 4,865,706. A related application, is Ser. No. 07/143,442, filed Jan. 12, 1988, now U.S. Pat. No. 4,865,707 which is another continuation-in-part application based on the same parent application.
Priority Data    
USPTO Field of Search     204/182.8 204/180.1 204/299 R
Patent Tags     high performance microcapillary gel electrophoresis
   
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