WikiPatents - Community Patent Review
Create Free Account  |  License or Sell Your Patent  |  WikiPatents Marketplace  |  WikiPatents Blog
Username:  Password:  
    
Advanced Search
High performance microcapillary gel electrophoresis    
United States Patent4997537   
Link to this pagehttp://www.wikipatents.com/4997537.html
Inventor(s)Karger; Barry L. (Newton, MA); Cohen; Aharon (Brookline, MA)
AbstractA microcapillary column for high performance electrophoresis. A preferred column includes a microcapillary, a thin layer of coating material covalently bonded to the inner surface of the microcapillary wall, a thin layer of a hydrophilic polymer absorbed on the layer of coating material, and a gel comprising polyacrylamide polymerized in the tube, filling it. The gel-containing microcapillary is prepared by covalently bonding a layer of a suitable coating material to the inner surface of the microcapillary wall, applying a layer of hydrophilic polymer, and then causing a mixture of monomer with or without crosslinking agent, initiator, and polymerization catalyst to react in the bore of the microcapillary to form a polymeric matrix. In electrophoresis, the gel-containing microcapillary provides peak efficiencies in excess of 100,000 theoretical plates and in some instances over 1,000,000 theoretical plates within separation times of less than thirty minutes, permits trace level determinations of molecular weights, and permits electrophoretic operation at fields of 300 V/cm or higher, resulting in extremely high resolution separations.
   














 Title Information Submit all comments and votes
 
Patent Text Patent PDF Print Page Summary File History
Plain text PDF images Print Summary File History
Drawing from US Patent 4997537
High performance microcapillary gel electrophoresis - US Patent 4997537 Drawing
High performance microcapillary gel electrophoresis
Inventor     Karger; Barry L. (Newton, MA); Cohen; Aharon (Brookline, MA)
Owner/Assignee     Northeastern University (Boston, MA)
Patent assignment
All assignments
Publication Date     March 5, 1991
Application Number     07/406,080
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     September 12, 1989
US Classification     204/453 204/455 204/605
Int'l Classification     G01N 027/26 G01N 027/28 B01D 057/02
Examiner     Niebling; John F.
Assistant Examiner     Starsiak Jr.; John S.
Attorney/Law Firm     Weingarten, Schurgin, Gagnebin & Hayes
Address
Parent Case     CROSS-REFERENCE TO RELATED APPLICATIONS This is a continuation-in-part of application Ser. No. 07/359,728, filed May 31, 1989, pending, which is hereby incorporated by reference. Application Ser. No. 07/359,728 is a continuation of parent application Ser. No. 06/921,311, filed October 21, 1986, now U.S. Pat. No. 4,865,706. A related application, is Ser. No. 07/143,442, filed Jan. 12, 1988, now U.S. Pat. No. 4,865,707 which is another continuation-in-part application based on the same parent application.
Priority Data    
USPTO Field of Search     204/182.8 204/180.1 204/299 R
Patent Tags     high performance microcapillary gel electrophoresis
   
Enter a comma (,) or semicolon (;) between multiple tag words/phrases.
Describe this patent:
 Amusing   
 Clever   
 Complex   
 Efficient   
 Historic   
 Important   
 Innovative   
 Interesting   
 Practical   
 Simple   
[no votes]
Patent WIKI

Share information and news about this patent, including information and news about the technology, inventors, company, ligation and licensing.

 References Submit all comments and votes
 
*references marked with an asterisk below are user-added references
 U.S. References
 
Add a new US reference:  
ReferenceRelevancyCommentsReferenceRelevancyComments
2748074



[0 after 0 votes]
3691054



[0 after 0 votes]
3728145



[0 after 0 votes]
3783118



[0 after 0 votes]
3876775



[0 after 0 votes]
4865707
Karger
204/453
Sep,1989

[0 after 0 votes]
4865706
Karger
427/8
Sep,1989

[0 after 0 votes]
4747919
Anderson
204/455
May,1988

[0 after 0 votes]
4725343
Hjerten
204/548
Feb,1988

[0 after 0 votes]
4699705
Ogawa
204/469
Oct,1987

[0 after 0 votes]
4690749
Van Alstine
204/454
Sep,1987

[0 after 0 votes]
4680201
Hjerten
204/601
Jul,1987

[0 after 0 votes]
4668359
Postle
204/606
May,1987

[0 after 0 votes]
4666829
Glenner
435/6
May,1987

[0 after 0 votes]
4665164
Pernemalm
536/120
May,1987

[0 after 0 votes]
4657656
Ogawa
204/469
Apr,1987

[0 after 0 votes]
4650674
Aggarwal
424/85.5
Mar,1987

[0 after 0 votes]
4650556
Hashiue
204/466
Mar,1987

[0 after 0 votes]
4640759
Hashiue
204/618
Feb,1987

[0 after 0 votes]
4613459
Cantor
530/351
Sep,1986

[0 after 0 votes]
4600641
Ogawa
204/616
Jul,1986

[0 after 0 votes]
4588492
Bier
204/629
May,1986

[0 after 0 votes]
4582868
Ogawa
204/469
Apr,1986

[0 after 0 votes]
4579783
Ogawa
204/616
Apr,1986

[0 after 0 votes]
4548870
Ogawa
204/616
Oct,1985

[0 after 0 votes]
4548869
Ogawa
204/616
Oct,1985

[0 after 0 votes]
4533307
Ansorge
425/90
Aug,1985

[0 after 0 votes]
4512896
Gershoni
210/635
Apr,1985

[0 after 0 votes]
4503147
Nakajima
435/25
Mar,1985

[0 after 0 votes]
4481094
Fernandez de Castro
204/468
Nov,1984

[0 after 0 votes]
4471058
Smith
435/7.4
Sep,1984

[0 after 0 votes]
4461833
Gordon
435/183
Jul,1984

[0 after 0 votes]
4460694
Fletcher
436/531
Jul,1984

[0 after 0 votes]
4451446
Vandevelde
424/197.11
May,1984

[0 after 0 votes]
4443427
Reinherz
530/388.75
Apr,1984

[0 after 0 votes]
4442655
Stroetmann
53/428
Apr,1984

[0 after 0 votes]
4427658
Maubois
514/2
Jan,1984

[0 after 0 votes]
4415655
de Castro
435/17
Nov,1983

[0 after 0 votes]
4415428
Nochumson
204/606
Nov,1983

[0 after 0 votes]
4362612
Bier
204/627
Dec,1982

[0 after 0 votes]
4358358
Rhodes
435/285.2
Nov,1982

[0 after 0 votes]
4338396
Kiyasu
435/17
Jul,1982

[0 after 0 votes]
4321121
Gurske
204/469
Mar,1982

[0 after 0 votes]
4319976
Gurske
204/469
Mar,1982

[0 after 0 votes]
4319975
Cook
204/469
Mar,1982

[0 after 0 votes]
4312739
Hansson
204/469
Jan,1982

[0 after 0 votes]
4312727
Shainoff
204/469
Jan,1982

[0 after 0 votes]
4290911
Cook
204/456
Sep,1981

[0 after 0 votes]
4284491
Vesterberg
204/606
Aug,1981

[0 after 0 votes]
4275196
Shainoff
536/115
Jun,1981

[0 after 0 votes]
4205129
Podolsky
435/193
May,1980

[0 after 0 votes]
4204929
Bier
204/518
May,1980

[0 after 0 votes]
4152410
Ishii
435/7.25
May,1979

[0 after 0 votes]
4139346
Rabbani
422/56
Feb,1979

[0 after 0 votes]
4132769
Osther
424/174.1
Jan,1979

[0 after 0 votes]
4118481
Schnabel
514/12
Oct,1978

[0 after 0 votes]
3956273
Guiseley
536/120
May,1976

[0 after 0 votes]
3616457
Hjerten
62/129
Oct,1971

[0 after 0 votes]
 Foreign References
 Other References
 Market Review Submit all comments and votes
   
Market Size
Estimate the gross annual revenues of the relevant market sector:
> $10B
$5B - $10B
$2B - $5B
$500M - $2B
$100M - $500M
$10M - $100M
$1M - $10M
$500K - $1M
$100K - $500K
< $100K
[No votes]
$0
 
$0   $2.5B   $5B   $7.5B   $10B
Market Share
Estimate the percentage of the relevant market sector this invention will capture:
75% - 100%
50% - 74.99%
25% - 49.99%
10 - 24.99%
5 - 9.99%
2 - 4.99%
1 - 1.99%
< 1%
[No votes]
0.0%
 
0%   25%   50%   75%   100%
Reasonable Royalty
What percentage of gross sales should the inventor or assignee be paid?
75% - 100%
50% - 74.99%
25% - 49.99%
10 - 24.99%
5 - 9.99%
2 - 4.99%
1 - 1.99%
< 1%
[No votes]
0.0%
 
0%   25%   50%   75%   100%
Public's "Guesstimation" of Royalty Value
Market SizeN/A[No votes]
xMarket ShareN/A[No votes]
xReasonable RoyaltyN/A[No votes]

N/A

License Availablity
If you are NOT the owner or assignee, answer here:
Yes, license is available for purchase

No, license is not currently available



[No votes]
License Availablity
If you ARE the owner or assignee, answer here:
Yes, license is available for purchase

No, license is not currently available



[No votes]
Competitive Advantage
Does this invention have a significant competitive advantage over similar technologies?
Yes

No



[No votes]
Most helpful competitive advantage comment
[No comments]

Commercial Alternatives
Are there viable commercial alternatives for this invention?
Yes

No



[No votes]
Most helpful commercial alternative comment
[No comments]