A stable, food-compatible liposome is prepared by dissolving a lipophilic material in a phospholipid followed by the addition of water or an aqueous solution and mixing by sonicating to producing a liposome having the lipophilic material encapsulated in the lipid bilayer. The preferred lipophilic materials include any readily oxidizable lipid and in particular the omega-3 fatty acid containing fish oils. Other lipophilic materials which can be encapsulated in the lipidic bilayer include flavorants, acidulants, preservatives and antioxidants. The resulting liposomes provide a stabilizing vehicle for the lipophilic materials to reduce the occurrence of oxidation and rancidity. Liposomes prepared according to the disclosed method exhibit none of the unpleasant odor and flavor characteristics normally associated with oxidized or rancid oils. The liposomes provide an extended shelf life of the unstable oils and can be added directly to the food product as a dispersion during the manufacturing stage or dried to a free flowing powder for later use.
Method of stabilizing polyunsaturates by adding thereto (i) ascorbic acid or an ester or salt thereof, and (ii) a phosphorylated mono- or di-fatty acyl glyceride or a salt thereof, and optionally a tocopherol or tocotrienol antioxidant, and a method of preparing stable pharmaceutical, nutritional or veterinary compositions.
The present invention concerns injectable blood pool contrast agents for NMR and X-ray imaging purpose. These blood pool agents carry imaging contrast enhancers, e.g. paramagnetic or, respectively, radio-opaque compounds for imaging the circulation and/or circulation targeted organs. The blood pool agent compositions are formulated to protect the contrast agents from early removal by the reticulo-endothelial (RES) system of the liver and the spleen, so that they stay in the circulation long enough to provide good images of the blood vessels and blood perfused organs. X-ray and NMR imaging of the circulation and of targeted organs can strongly assist in diagnosing possible ailments in human and animal patients.
A method for inhibiting the oxidation of edible oils and fats by forming a reverse micelle by admixing a mixture of an aqueous solution containing a water-soluble antioxidant with a surfactant and said oils or fats.
The present invention provides compositions for, a method of suppressing the rise in plasma concentrations of atherogenic lipoproteins after administration of an agent having small acceptors of cholesterol, other lipids or compounds. The method includes the step of co-administering an effective amount of a multiplicity of an agent having large liposomes that include phospholipids substantially free of sterol with the administration of the agent having the small acceptors. The atherogenic lipoproteins include LDL, VLDL, IDL, .beta.-VLDL, Lp(a), a lipoprotein containing apolipoprotein-B, oxidized lipoproteins, and modified lipoproteins. The agent having small acceptors consists essentially of small acceptors and in which the agent having large liposomes consists essentially of large liposomes. In a variant, co-administration of the agent having large liposomes is simultaneous with the administration of the agent having small acceptors. Optionally, co-administration of the agent having large liposomes is separated in time from the administration of the agent having small acceptors by an effective time period. An improved pharmaceutical composition for reducing the size of arterial lesions that enters the liver of a subject is also provided the improvement comprises an anti-oxidant and derivatives thereof. The invention also provides an improved mode of operation of liposomes utilizing the improvements described herein.
The present invention generally relates to inhibition of oxidation of polyunsaturated lipids by mixing the polyunsaturated lipids with a combination of polyamines providing a unique anti-oxidative effect on the polyunsaturated lipids. A especially advantageous combination of polyamines used in this regard includes spermine and a different linear aliphatic polyamine, such as spermidine, putrescine, or mixtures thereof. The rate of off-flavor development is significantly reduced in polyunsaturated lipids blended with such combinations of different polyamines. In addition, polyunsaturated lipid-containing materials and compositions can be stabilized using edible, non-toxic anti-oxidants based on such polyamine combinations. Omega-3 fatty acids and compositions containing them are especially well-suited for processing in this manner. The stabilized polyunsaturated lipid-containing products obtained in this manner have extended shelf-life while permitting the health and nutritional value of the treated lipids to be more fully accessed.
