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Dosimetric technique for stereotactic radiosurgery same    

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United States Patent5027818   
Link to this pagehttp://www.wikipatents.com/5027818.html
Inventor(s)Bova; Frank J. (Gainesville, FL); Friedman; William A. (Gainesville, FL)
AbstractStereotactic radiosurgery is facilitated by a technique for computing the doses at various points within the patient's body. In particular, the doses are computed at a relatively high density of points within a fine dose grid and at a relatively low density of points within a coarse dose grid. In that fashion, the user can quickly obtain necessary information about the radiation dose distribution before implementation of a proposed treatment plan. An advantageous technique of locating the intersection between the radiation beam and the contour or other surface of the patient is also provided. The method is especially well suited for use with a particular structure which allows one to utilize relatively narrow beam widths as a result of great mechanical accuracy.
   














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Drawing from US Patent 5027818
Dosimetric technique for stereotactic radiosurgery same - US Patent 5027818 Drawing
Dosimetric technique for stereotactic radiosurgery same
Inventor     Bova; Frank J. (Gainesville, FL); Friedman; William A. (Gainesville, FL)
Owner/Assignee     University of Florida (Gainesville, FL)
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Publication Date     July 2, 1991
Application Number     07/353,816
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     May 18, 1989
US Classification     600/427 378/65 600/429 606/130
Int'l Classification     A61B 006/00
Examiner     Cohen; Lee S.
Assistant Examiner     Pfaffle; Krista M.
Attorney/Law Firm     Kerkam, Stowell, Kondracki & Clarke
Address
Parent Case     CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part (CIP) of International Application No. PCT/US 88/04 303 filed Dec. 2, 1988 designating the U.S., among other countries. That application will, in its U.S. stage, be a CIP of U.S. application 128,273 filed Dec. 3, 1987 and now abandoned. Both of those applications are incorporated by reference.
Priority Data    
USPTO Field of Search     128/653 R 128/654 128/659 378/65 606/130 364/413.14 364/413.15 364/413.16 364/413.22 364/413.26
Patent Tags     dosimetric technique stereotactic radiosurgery
   
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What is claimed is:

1. A method for patient care comprising the steps of:

(a) localizing a target within a patient;

(b) subjecting the patient to an imaging system with a display to generate patient reference data in the form of x,y,z coordinates of the target and adjacent portions of the patient;

(c) supplying the patient reference data to a dosimetric computer connected to said display;

(d) inputting into the dosimetric computer a proposed plan for applying at least one beam of radiation to the patient from at least one source and from at least two different directions;

(e) selecting a plane of the patient for display of a distribution of radiation which would result from the proposed plan;

(f) displaying on said display a selected plane patient image corresponding to the selected plane by operation of the imaging system;

(g) determining the distribution of radiation within the selected plane by calculating the radiation dose at points spaced by distance D1 within a fine dose grid relatively close to the target and calculating the radiation dose at points spaced by distance D2, greater than D1, within a coarse dose grid outside said fine dose grid, the dosimetric computer performing the calculations for the radiation dose at a greater density of points in the fine dose grid and at a lower density of points in the coarse dose grid; and

(h) displaying data on the display from the radiation dose calculations.

2. The method of claim 1 wherein some data resulting from the radiation dose calculations is placed on the patient image in the display.

3. The method of claim 2 wherein the proposed plan includes at least a first arc through which the beam is applied to the patient, said first arc being in a first arc plane, and wherein said inputting step includes the substeps of:

selecting the first arc plane; displaying a first arc plane patient image corresponding to the first arc plane on the display;

creating a bit map of pixels on the display to said x,y,z coordinates of the patient reference data;

identifying each pixel which makes up an outside contour of the patient;

storing the beginning and end of the first arc;

drawing a line between the source at a given location and an isocenter within the target;

finding the intersection pixel of the line and the pixels corresponding to the outside contour;

referencing the bit map to identify the x,y,z coordinates of the intersection pixel as a beam entrance point;

repeating the drawing, finding, and referencing substeps to identify additional beam entrance points corresponding to different source locations; and

storing the beam entrance points, these beam entrance points corresponding to the center of the beam at different source locations.

4. The method of claim 3 wherein the stored beam entrance points are used to perform the radiation dose calculations.

5. The method of claim 4 wherein the radiation dose calculations are performed for each of said different source locations based on radiation entering only at said beam entrance points such that edge effects are ignored.

6. The method of claim 5 wherein the width of each beam used in the proposed plan is less than 5 cm such that ignoring edge effects will not introduce substantial errors.

7. The method of claim 6 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

8. The method of claim 4 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

9. The method of claim 1 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

10. A method for patient care comprising the steps of:

(a) localizing a target within a patient;

(b) subjecting the patient to an imaging system with a display to generate patient reference data in the form of x,y,z coordinates of the target and adjacent portions of the patient;

(c) supplying the patient reference data to a dosimetric computer connected to said display;

(d) inputting into the dosimetric computer a proposed plan for applying at least one beam of radiation to the patient from at least one source and from at least two different directions;

wherein the proposed plan includes at least a first arc through which the beam is applied to the patient, said first arc being in a first arc plane, and wherein said inputting step includes the substeps of:

selecting the first arc plane;

displaying a first arc plane patient image corresponding to the first arc plane on the display;

creating a bit map of pixels on the display to said x,y,z coordinates of the patient reference data;

identifying each pixel which makes up an outside contour of the patient;

storing the beginning and end of the first arc;

drawing a line between the source at a given location and an isocenter within the target;

finding the intersection pixel of the line and the pixels corresponding to the outside contour;

referencing the bit map to identify the x,y,z coordinates of the intersection pixel as a beam entrance point;

repeating the drawing, finding, and referencing substeps to identify additional beam entrance points corresponding to different source locations; and

storing the beam entrance points, these beam entrance points corresponding to the center of the beam at different source locations.

11. The method of claim 10 further comprising:

selecting a plane of the patient for display of a distribution of radiation which would result from the proposed plan;

displaying on said display a selected phase patient image corresponding to the selected plane by operation of the imaging system;

determining the distribution of radiation within the selected plane; and displaying data on the display resulting from the distribution determination.

12. The method of claim 11 wherein the determination of the distribution is accomplished by calculating the radiation dose at points spaced by distance D1 within a fine dose grid relatively close to the target and calculating the radiation dose at points spaced by distance D2, greater than D1 within a coarse dose grid outside said fine dose grid; the dosimetric computer performing the calculations for the radiation dose at a greater density of points in the fine dose grid and at a lower density of points in the coarse does grid.

13. The method of claim 12 wherein the stored beam entrance points are used to perform the radiation dose calculations.

14. The method of claim 13 wherein the radiation dose calculations are performed for each of said different source locations based on radiation entering only at said beam entrance points such that edge effects are ignored.

15. The method of claim 14 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

16. The method of claim 15 wherein the beam or beams applied to the patient are less than 5 cm in width.

17. The method of claim 10 further comprising the step of:

subjecting the patient to radiation in accord with the proposed plan.

18. The method of claim 17 wherein the beam or beams applied to the patient are less than 5 cm in width.

19. A method for patient care comprising the steps of:

(a) localizing a target within a patient;

(b) subjecting the patient to an imaging system with a display to generate patient reference data in the form of x,y,z coordinates of the target and adjacent portions of the patient;

(c) supplying the patient reference data to a dosimetric computer connected to said display;

(d) inputting into the dosimetric computer a proposed plan for applying at least one beam of radiation to the patient from at least one source and from at least two different directions;

(e) selecting a plane of the patient for display of a distribution of radiation which would result from the proposed plan;

(f) displaying on said display a patient image corresponding to the selected plane by operation of the imaging system;

(g) determining the distribution of radiation within the selected plane by calculating the radiation dose at points spaced by distance D1 within a fine dose grid relatively close to the target and calculating the radiation dose at points spaced by distance D2, greater than D1, within a coarse dose grid outside said fine dose grid, the dosimetric computer performing the calculations for the radiation dose at a greater density of points in the fine dose grid and at a lower density of points in the coarse dose grid; and

(h) outputting data from the radiation dose calculations.

20. The method of claim 19 further comprising the step of subjecting the patient to radiation in accord with the proposed plan using a stereotactic radiosurgery apparatus comprising:

a gantry supported for rotation about a gantry axis, the gantry having a radiation-emitting head for movement in an arc in a radiation plane about a center point corresponding to an intersection of the gantry axis and the radiation plane, said gantry axis being normal to said radiation plane;

a collimator disposed to focus radiation from said radiation-emitting head on said center point; and

collimator linking means for linking movement of said collimator to said radiation-emitting head for automatic rotation of said collimator in said radiation plane and about said gantry axis upon rotation of said gantry, said collimator linking means allowing said collimator to track rotation of said gantry with no or minimal transfer of positioning inaccuracies from said gantry to said collimator.
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A portion of the disclosure of this patent document contains material subject to copyright protection. The copyright owner has no objection to facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyright rights whatsoever.

REFERENCE TO THE MICROFICHE APPENDIX

This application was filed with a computer program listing printout which has been submitted in the form of a "microfiche appendix". The microfiche appendix consists of four sheets of microfiche consisting of a total of 237 frames and is not a part of the printed patent.

BACKGROUND OF THE INVENTION

This invention relates generally to dosimetry for a radiosurgery system employing multiple beams of radiation focused onto a stereotactically localized target, and more particularly to a dosimetry technique which quickly provides useful data for planning patient treatment.

In 1951, Dr. Lars Leksell coined the term "radiosurgery", to describe the concept of focusing multiple beams of external radiation on a stereotactically localized intracranial target. After experimentation with standard X-ray treatment devices, proton beam, and linear accelerators, he and his collaborators developed a device which is called the GAMMA KNIFE (currently marketed by the Electra Corporation, Stockholm, Sweden). The device consists of a hemispheric array, currently containing 201 Cobalt-60 sources. The radiation from each of these sources is collimated and mechanically fixed, with great accuracy, on a focal point at the center of the hemisphere. When a patient has a suitable lesion for treatment (usually an intracranial arteriovenous malformation), it may be precisely localized with another device called a stereotactic frame. Using the stereotactic apparatus, the intracranial target is positioned at the focal point of the GAMMA KNIFE. Since each of the 201 radiation pathways is through a different area of the brain, the amount of radiation to normal brain tissue is minimal. At the focal point, however, a very sizable dose is delivered which can, in certain cases, lead to obliteration of the lesion. This radiosurgical treatment is, in some instances, a much safer treatment option than conventional surgical methods.

Several GAMMA KNIFE devices are currently being used worldwide for stereotactic radiosurgery and have been used to treat approximately 1500 patients. The results of treatment, as well as many technical issues, have been discussed in multiple publications. Several factors, however, have impeded the widespread usage of this device. First, the device costs about $2.2 Million Dollars, U.S. Second, the Nuclear Regulatory Commission has ruled that this device cannot be shipped loaded in the U.S.A. Consequently, loading must be done on site, necessitating the construction of a portable hot cell. Third, the half life of Cobalt-60 is 5.2 years, which requires reloading the machine, at great expense, every 5-10 years. Fourth, the dosimetry system currently marketed with the device is relatively crude, especially when utilized with more modern imaging modalities such as CT scan and MRI scan.

An alternative method for radiosurgery involves irradiation of intracranial targets with particle beams (i.e., proton or helium). In this instance, one does not rely solely on multiple cross-fired beams of radiation. A physical property of particle beams, called the "Bragg-peak effect", allows one to deliver the majority of the energy of a small number of beams (approximately 12) to a precisely predetermined depth. Multiple publications regarding particle irradiation of intracranial lesions (especially pituitary tumors and arteriovenous malformations) have appeared in the literature. The results have not generally been as good as those obtained with the GAMMA KNIFE. This may, however, be solely a consequence of patient selection criteria. Particle beam devices require the availability of a cyclotron. Only a few such high energy physics research facilities exist in the world.

A third current radiosurgical method uses a linear accelerator (LINAC) as the radiation source. As mentioned above, Leksell rejected the LINAC as mechanically inaccurate. More recently, groups from Europe have reported their methods for radiosurgery with LINAC devices. In the United States, researchers at the Peter Bent Brigham Hospital in Boston have developed a prototype LINAC system using highly sophisticated computer techniques to optimize dosimetry. Thus far, approximately 12 patients have been treated with good results. This LINAC system, however, suffers from certain mechanical inaccuracies which have limited its use. In addition, the computer dosimetry system employed is very time consuming, rendering the treatment program inefficient.

Currently, there is great interest in radiosurgery. Although the GAMMA KNIFE represents the "gold standard", its great expense and requirement for frequent replenishment of radiation sources have discouraged most potential users. The proton beam devices are never likely to be widely available because of the requirement for high-energy particle beam source (cyclotron). The linear accelerator offers an attractive alternative to such devices. However, a major disadvantage of known linear accelerator based systems is the need for time consuming (e.g., several hours) computer calculations for determining the radiation distributions.

Before subjecting a patient to stereotactic radiosurgery, the tumor or other target area within the patient must be localized. This may be accomplished by stereotactic angiography or by CT (computer tomography) localization. After the localization of the tumor or other target area, a CT localizer (or an NMR imaging system) should be used on the patient, even if the original localization was using stereotactic angiography. The data from the CT scan and the angiographic films, if any, should be transferred to a computer system used for calculating the dosage.

When applying radiation to a patient, it is important that the radiation be concentrated on the target area and minimized for the patient's healthy tissues. It is especially important that the radiation be minimized on certain critical structures. For example, if using radiation treatment on a patient's brain, it may be important that the radiation dosage applied to the patient's optic nerves is minimized.

Before a physician applies the radiation to the patient, the physician may decide on two or more arcs which will be used for applying the radiation to the patient. In particular, the physician decides upon the plane in which the radiation beam will be applied in an arc to the patient's target area. The localization data and the proposed treatment arcs are input into a dosimetric computer system. That computer system generates a value for the radiation at each point in a grid extending throughout the patient's skull (assuming that the radiation is for the treatment of a target area within the brain). It is this process that is very time consuming and may require over four hours of computer time. Specifically, the process usually generates the value of the radiation dose at over 250,000 points within the patient's skull. After the doctor has received the radiation distributions from the computer, the doctor may decide that one or more critical structures is receiving too much radiation. Alternately, the doctor may decide that the target area is not receiving sufficient radiation. At any rate, the doctor may be required to revise the arcs through which the radiation source will travel in order to apply radiation to the tumor. It would then be necessary to repeat the very time consuming process of recalculating the radiation distribution.

Some prior dosimetric computer systems have been designed in which the radiation distribution may be calculated and shown or supplied for a smaller volume than the complete volume of the patient's skull. These type of systems require that one repeatedly indicate the area or volume for which the radiation distribution is desired. Although this may give faster results than the process giving the complete radiation distribution, the results are somewhat incomplete unless the doctor repeatedly selects numerous areas or zones for which the radiation distribution is requested. Each radiation distribution that is generated shows only a portion of the plane of view illustrating the radiation distributed within the patient.

The time-consuming nature of prior dosimetric systems is at least partly due to the generally used technique for calculating where the beam goes into the patient's skull. Specifically, the patient's skull may be simulated by thousands (often hundreds of thousands) of tiles and the usual "tiling" technique uses a series of simultaneous equations in order to calculate where the beam of radiation enters the patient's skull.

A further reason for the time-consuming nature of prior dosimetric procedures is that the resolution must be sufficiently high to give adequate details of the radiation distribution. In other words, the points at which the radiation dosages are given must be sufficiently close together that the doctor will have enough information to make proper decisions. On the other hand, this requirement for high resolution causes one to use so many data points that the calculations will, on most computers, take a tremendous amount of time.

A further reason for the time-consuming nature of previous dosimetric techniques is that such techniques require radiation distribution calculations based upon relatively complex mathematical models. The models require that the entrance width of the beam be taken into account because the width of the beam is generally large compared to the curvature of the patient's skull. In other words, the center of the radiation beam might be perpendicular to the patient's skull, but the beam is sufficiently wide compared to the curvature of the patient's skull that the edge of the beam is entering the patient's skull at a significantly different angle than at the beam center. Since the portion of the beam entering at the edge has a significantly different angle than the center of the beam, prior systems have generally taken into account this edge effect. This increases the complexity of the calculations. A further reason for the complexity of calculating the radiation distribution is that prior techniques usually require calculation of the primary radiation and the scattered radiation. The primary radiation is radiation which reaches a point inside the target volume with few interactions with the overlying material, whereas the scattered radiation is the radiation distribution resulting from the interaction of the primary radiation with the overlying structures or materials away from the primary path. The scattered radiation does not proceed along the same directional path as the primary radiation or the beam.

A further disadvantage of prior dosimetric systems is that they lack flexibility in terms of providing requested data.

OBJECTS AND SUMMARY OF THE INVENTION

A primary object of the present invention is to provide a new and improved dosimetric technique for stereotactic radiosurgery.

A more specific object of the present invention is to provide an improved dosimetric technique which avoids or minimizes the problems associated with the prior dosimetric techniques as discussed above.

The present invention uses localization in order to determine the target area (such as a tumor or other area to be treated) within a patient. An imaging system is used on the patient, such as a CT scanner, angiography, or NMR system. Using the localization data obtained, an operator supplies a computer with a series of arcs corresponding to the manner of applying radiation to the target area within the patient. The arcs are input into a computer system which has been programmed to perform the present dosimetric analysis. The computer system will very quickly generate data for the doctor showing the radiation distribution within the patient from the proposed arcs.

Advantageously, the present invention avoids many of the calculations of the prior dosimetric systems by providing a different resolution within a zone close to the isocenter (i.e., a location within the target zone at which the radiation will be most concentrated) and a zone removed from the isocenter. In other words, there might be a grid in the high-resolution zone where the radiation distribution is calculated every one millimeter, whereas the radiation distribution would be calculated every five millimeters in a grid outside of the high resolution zone or area. Accordingly, the number of data points may be significantly reduced without lowering the useful information supplied to the doctor since the low-resolution zone or area corresponds to locations where the radiation distribution changes only very slowly.

Another advantageous technique of the present invention is to use a thin beam of radiation such that the scattered radiation may be ignored and the beam may be modeled as though it strikes the patient's skull at a single point. In other words, the beam may be sufficiently thin compared to the curvature of the patient's skull so that one may ignore the edge effects discussed above.

A further advantageous feature of the present invention is that one avoids the tiling technique to determine where the beam enters the patient's skull. Instead of performing the simultaneous equations, the present dosimetric technique uses a computer to graphically proceed along the radiation beam from the target area towards the source of the radiation. The computer can recognize whether the beam is inside the patient's skull or has just transversed into the outside of the patient's skull.

A further significant feature of the present invention is that it allows the user to arbitrarily select key planes for display of the radiation distribution.

BRIEF DESCRIPTION OF THE DRAWINGS

The above and other features of the present invention will be more readily understood when the following description is considered in conjunction with the accompanying drawings wherein like parts have the same number throughout and in which:

FIGS. 1 and 2 are a side elevation view and an end elevation view, respectively, of conventional linear accelerator apparatus which may be employed for stereotactic radiosurgery, the figures illustrating possible misalignments of a radiation-emitting head of the apparatus;

FIGS. 3 and 4 are a side elevation view and a top view, respectively, of stereotactic radiosurgery apparatus useful in implementing the invention;

FIG. 3A is a side exploded view of a linking arrangement for linking a collimator to a radiation-emitting head;

FIG. 4A is a top view showing parts of a floorstand support arrangement:

FIG. 4B shows a side exploded view with some parts in cross-section of parts of FIG. 4A;

FIGS. 5 and 6 are a side elevation view and a top view, respectively, of guiding structure;

FIG. 5A is a top exploded view of parts from FIG. 5;

FIG. 7 is a perspective view illustrating conceptually a preferred form of a main arcing bearing;

FIG. 8 is a perspective view illustrating conceptually a preferred form of a gimbal bearing;

FIG. 9 shows an alternate arrangement for supporting a collimator;

FIG. 10 shows an alternate arrangement for supporting a floorstand;

FIG. 11 shows a further alternative arrangement for supporting both the collimator and a floorstand by way of a common support;

FIG. 12 shows a side view of an arrangement for linking rotation of a floorstand to rotation of a treatment table;

FIG. 13 shows a cross-section view of the connection between the floorstand and treatment table of FIG. 12;

FIG. 14 shows a side view of an alternate arrangement for linking a floorstand to a table;

FIG. 15 shows a simplified flow chart of the overall patient treatment process according to the present invention;

FIG. 16 shows a simplified flow chart of a method of setting a beam treatment arc and determining beam entrance points according to the present invention;

FIG. 17 is a view of the display produced during a portion of the present process;

FIG. 18 is a simplified flow chart showing how the present process provides for displaying the radiation distribution in an arbitrarily selected plane;

FIG. 19 is a simplified drawing showing a radiation beam entering a patient and illustrating several principles of operation of the present invention;

FIGS. 20A and 20B show beam intensity distributions respectively as a function of the distance from the center of a beam and the depth in tissue of the beam;

FIG. 21 is a simplified flow chart showing how the present process computes the radiation dose resulting from the radiation beam being swept through a particular arc;

FIG. 22 is a simplified flow chart illustrating the computation of the radiation dose at a particular point from a beam;

FIG. 23 shows a view screen produced by the process of the present invention;

FIG. 24 shows a view screen as produced without any windows;

FIG. 25 shows how the present invention includes radiation dose information on the display of a portion of the patient's body;

FIG. 26 shows a view screen produced by the present invention wherein the vertical and horizontal distributions of radiation are plotted; and

FIG. 27 shows a simplified schematic of a system for implementing the present technique.

DETAILED DESCRIPTION

The process of the present invention is especially well adapted for use in conjunction with a specific linear accelerator structure which will be initially described herein. However, it should be noted that the present dosimetric technique has more general application.

FIGS. 1 and 2 illustrate a conventional LINAC device which comprises a fixed base 10 and an L-shaped gantry 12 which is rotatable with respect to the base about a horizontal axis 14. The gantry carries a radiation-emitting head 16, and rotation of the gantry causes the head to sweep through an arc R located in a substantially vertical plane which is perpendicular to the horizontal axis. The dotted lines in the figures indicate potential misalignments caused by mechanical inaccuracies or sag of the gantry in any of the directions indicated in the FIGS. as A, B or z. These misalignments result in misfocusing of the radiation from the head 16 and are intolerable in radiosurgery, for the reasons noted hereinafter.

In order to best understand the invention, the three principle components of a stereotactic radiosurgery procedure will first be explained. These components are localization, dose computation and optimization, and execution of treatment. The ultimate accuracy of the procedure is dependent on each of these components.

The first component in the procedure involves the localization of the tumor. This is accomplished by one of two means. Currently, the method of choice is through stereotactic angiography. The procedure begins with the stereotactic ring being fitted to the patient. An angiographic localizing device is then attached to the ring. This device is known and consists of four sets of fiducial alignment markers. Two sets of these markers project onto each of two orthogonal angiographic x-rays. By location of the fiducial points and the target on each x-ray, the precise, x, y, z coordinates of the target (to an accuracy of 1 mm) relative to the stereotactic ring can be derived. While this part of the procedure allows the coordinates of the target relative to the localization ring to the determined, more anatomical information is needed for dosimetric analysis.

The next step replaces the angiographic localizing device with another localizer specially designed for localization in computer tomography. This is the standard BRW CT Localizer. The patient is aligned in the CT gantry and contiguous 5 mm slices, beginning at the level of the localization ring and advancing superiorly past the top of the patient's skull, are obtained. If the target volume can be identified in the computerized tomography image, then the x, y, z coordinates of the target volume are again calculated. (This can provide a double check of the x, y, z coordinates relative to the stereotactic ring.) If not, then the target obtained from the angiographic procedure can then be superimposed onto the CT scan data.

With the digitally encoded data from the CT scan and the two angiographic films, the data may be then transferred to a dosimetry computer system. The CT scan provides three dimensional anatomical information of the patient allowing a solid patient model to be constructed. The coordinates of the target volume from the angiogram and the CT scan data are then merged.

Computation and Dose Optimization: In order for the high single fractions of radiation to be delivered to the target volume, a technique to concentrate the radiation at the target while spreading out the radiation to lesser concentrations throughout the normal tissues must be utilized. Moving the radiation source through multiple arcs achieves this objective. It is important for the radiotherapist and neurosurgeon to be able to examine the consequence of each portion of the arc. The computer system which computes the dosimetry must have the ability to display each arc segment. In the routine stereotactic procedure, it is anticipated that four arcs, three at 100 degrees and one at 240 degrees, will be utilized. The computer must allow the CT scan to be reformatted in each of these arc planes (relative to the patient's skull) so that each individual arc's dose distribution can be examined. If any particular arc results in an extensive dose to a critical structure, the therapist can alter the arc parameters to avoid the anatomical area of concern. The dosimetry system discussed in detail below will allow dose optimization through operator control. For as yet undeveloped more sophisticated versions, the operator will identify the target region and the areas where dose should be minimized. The computer will then, through use of an optimization algorithm, design the treatment which best concentrates the radiation over the tumor volume while minimizing the dose to normal tissues. The spacing between arcs, the size of the collimator, and the variation in arc length and weight will be parameters used in the optimization.

The method necessary for dose computation and optimization using a CT scan is complicated by the high resolution necessary in the procedure. The stereotactic targets can be identified to plus and minus a millimeter. The treatment portals can range anywhere from 1 to 3 cm in diameter. The spatial coordinates of the computational grid, in the area of the target, must be in the 1 mm range. However, there is little need for 1 mm accuracy outside about a 5 cm radius of the target itself. A 0.5 grid is adequate in this region. By working with both the 1 mm and 5 mm grids, the number of computation points at which a dose must be evaluated for the complex arcs can be vastly reduced.

Once the acceptable treatment scheme has been derived, the coordinates of the isocenter (focal point of the radiation), the collimator size, and the arc parameters are then transferred to the operator of the linear accelerator.

FIGS. 3 and 4 illustrate the stereotactic treatment setup. As shown, a patient is placed on a treatment table 20 which is supported by a member 22 on a rotating plate 24 positioned in the floor. The patient's head is immobilized by a stereotactic ring 26 which is connected to a BRW stereotactic floorstand 28 which has been modified in accordance with the invention (as will be explained shortly) so that the patient's head is at a predetermined location with respect to the radiation-emitting head 16 of the LINAC. As shown in FIG. 4, rotating plate 24 may be rotated, to position the table at different locations 20' as indicated by the dotted lines. Gantry 12 of the LINAC may be rotated about base 10 to swing treatment head 16 in an arc located in a vertical plane indicated by the dotted line 30 in FIG. 3. The radiation from head 16 is collimated by a collimator 32 and is confined to the vertical plane 30 in which the treatment head moves. FIG. 4 shows the gantry 12 swung over to one side such that the radiation enters the left side of the patient's head, and FIG. 3 shows the gantry in an upright position such that the radiation enters through the forehead of the patient. Collimator 32 focuses the radiation at an isocenter or center point 34 corresponding to the intersection of the horizontal axis 14 of rotation of the gantry and vertical plane 30. Center point 34 corresponds to the origin of the arc through which th