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Thiazolo [4,5-6] pyridine derivatives and anti-ulcerative composition containing same
   
Document Number
US Patent 5079255
Issued Date
January 7, 1992
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Abstract
Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.; X represents --NH--, --O-- or --S--; Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --; R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group; R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-membered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, and m and n each represent an integer from 0 to 2.
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Number of Claims:
8
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Owner
Published
January 7, 1992
Application Number
07/544,671
Filed
June 27, 1990
US Classification
514/303   546/114
Int'l Classification
C07D   498/00   (20060101)   C07D   498/04   (20060101)   C07D   513/00   (20060101)   C07D   513/04   (20060101)   C07D   471/04   (20060101)   C07D   471/00   (20060101)  
Examiner
Attorney/Law Firm
Priority Data
Jun 29, 1989 [JP] 1-165244 Nov 24, 1989 [JP] 1-303366
USPTO Field of Search
514/303   546/114  
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