The present invention relates to spiroisoindolines that are antagonists at the phencyclidine receptor of the N-methyl-D-aspartate receptor complex and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides processes for preparing the spiroisoindolines, intermediates useful for their synthesis, pharmaceutical compositions containing them, and methods for their use.
This invention relates to a removable load supporting stand for temporary attachment to a tree trunk or the like for use while hunting for example. According to the invention a stand is provided including a platform extending laterally outwardly from the tree trunk. The platform has a load supporting portion between opposing sides. Engaging means on an inward portion of the platform function to releasably engage an adjacent segment of the tree trunk. A chain at each of it's ends is secured to an opposing side of the platform. The chain releasably encompasses the tree trunk upward of the segment and defines a plane transverse an axis of the tree trunk. The chain is flexible in the plane and resistant to flexure perpendicular to the plane. Biasing means engage the chain and urge the chain in a direction of the plane to disengage the tree trunk. Preferably the chain is comprised of two parallel spaced apart rows of overlapping links transversely interconnected by pins disposed substantially normal to the plane, such that the links and pins define a longitudinal series of apertures therebetween. The biasing means preferably comprise an elongate flexible member having an inherent tendency to assume a selected configuration when unstressed.
This invention encompasses methods for the inhibition of a physiological disorder associated with amyloidogenic proteins, which method comprises administering to a human in need thereof an effective amount of a compound of Formula I ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## ##STR3## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamthylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.