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Description  |
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BACKGROUND OF THE INVENTION
The present invention relates generally to the diagnosis and treatment of patients having tumors or lesions. More particularly, the present invention relates to a method of and system for locating and treating such tumors or lesions in which the
same three-dimensional coordinate system used in diagnosing the location of the tumors or lesions is used to provide treatment for those tumors or lesions, by use of a computer and a stereotaxic ring.
Although a brain lesion as small as 2-3 millimeters can be localized on a computed tomography (CT) or magnetic resonance (MR) scanner, it cannot be treated with a correspondingly small radiation field(s) because the geometrical error associated
with the information transfer from scanner to a computer to an accelerator and then to the patient is greater than the dimensions of the lesion itself. Thus, the ability to conduct precision radiotherapy using, for example, x-rays, is determined by the
overall accuracy of the whole radiation therapy process, and not by the precision achieved in the individual diagnostic or therapeutic procedures.
While in the last fifteen years new technology has been introduced for nearly every procedure utilized in the diagnosis and treatment of brain lesions (for example, CT and MR scanners, treatment planning computers, compact linear accelerators,
etc.), no system and/or equipment has been offered or is available for integrating the radiotherapy process. Consequently, the overall precision of the process has not yet improved to the extent made possible by present knowledge and technology.
This application discloses a computer controlled stereotaxic radiotherapy system which integrates, using a patient halo or headpiece, the diagnosis, treatment planning, and subsequent repetitive radiotherapy treatment for treating such lesions.
Stereotactic devices for use in aiding treatment of lesions are known. Examples of such stereotactic apparatus include U.S. Pat. No. 4,638,798 to Shelden et al.; U.S. Pat. No. 4,617,925 to Laitinen; U.S. Pat. No. 4,608,977 to Brown; U.S.
Pat. No. 4,602,622 to Bar et al.; U.S. Pat. No. 4,465,069 to Barbier et al.; U.S. Pat. No. 4,341,220 to Perry; U.S. Pat. No. 4,256,112 to Kopf; U.S. Pat. No. 4,805,615 to Carol; U.S. Pat. No. 4,791,934 to Brunnett; U.S. Pat. No. 4,706,665 to
Gouda; U.S. Pat. No. 4,475,550 to Bremer et al. and U.S. Pat. No. Des. 288,368 to Van Buren et al.
While some of the above-referenced patents disclose utilizing a computer to analyze and determine the coordinates of a lesion with reference to a ring or halo attached to the patient's head during diagnosis, such as the Shelden et al. and Gouda
patents, none of those references are concerned with a computer controlled radiotherapy system which utilizes the coordinates developed from a CT or MR scanner. Not until applicants' invention was a system developed which integrates, under computer
control, the processing of the coordinates locating the lesion during diagnosis and the subsequent processing and utilization of those coordinates by the treatment apparatus.
SUMMARY AND OBJECTS OF THE INVENTION
In view of the foregoing, it should be apparent that there still exists a need in the art for a method of and system for providing for the treatment for intracranial lesions or other tumors in which the diagnostic and treatment devices are
integrated such that the coordinates of the lesion to be treated are provided to the treatment device in an accurate and direct manner. It is, therefore, a primary object of this invention to provide a method of and apparatus for integrating the
diagnostic and treatment devices and procedures used in connection with the diagnosis and treatment of lesions in such manner that the treatment coordinates are automatically developed or computed as a result of the diagnostic coordinates of the lesion
to be treated.
More particularly, it is an object of this invention to provide a system for locating and treating lesions as aforesaid which utilizes simple and reliable electronic circuitry which provides quick and accurate treatment coordinates as a result of
the lesion coordinates computed from the scans obtained with the diagnostic apparatus.
Still more particularly, it is an object of this invention to provide a lesion treatment system in which the treatment coordinates are integrated with the diagnostic coordinates by means of a headpiece attached to the head of the patient and a
base assembly attached to the treatment couches of both the diagnostic equipment and the treatment equipment.
Another object of the present invention is to provide a reliable and relatively inexpensive computer controlled stereotaxic radiotherapy system for use in treating lesions.
Briefly described, these and other objects of the invention are accomplished in accordance with the system aspects by providing a common mechanical system, (stereotaxic guide), which includes three major parts: a halo attached to the patient's
head, a base unit attached to the treatment couches of both the diagnostic equipment and the treatment equipment and a stereotaxic cage. The mechanical equipment is used to integrate the lesion coordinates determined by the diagnostic equipment with
those used by the treatment equipment to treat the lesion.
The halo is attached to the patient's cranium with skin piercing screws in a known manner and, is used in combination with the base assembly attached to the treatment couches of the respective diagnostic and treatment devices. The stereotaxic
phantom cage, which fits over the halo, is secured to the base unit and allows the coordinates of the lesion, as well as other points of interest, (e.g. magnetic field sensor phantom), to be determined in the patient coordinate system. The stereotaxic
guide also permits a subsequent transfer of the coordinates from the patient's coordinate system into the coordinate system of the diagnostic device, treatment planning computer, treatment equipment and the control computer.
The method of the present invention is carried out by first securing the halo to the head of the patient and then securing the halo to the base assembly portion of the mechanical system which is itself secured to the treatment couch of the
diagnostic equipment. The stereotaxic cage is then placed over the halo and secured to the base unit. A magnetic probe phantom or field sensor is secured to the halo and the diagnostic device is then used to obtain a series of diagnostic scans covering
the entire volume of interest, including the lesion and the probe. The stereotaxic coordinates of the lesion and the field sensor are determined from the obtained scans using the contrast points provided by the stereotaxic phantom cage on the scans.
The relation of the patient and scanner coordinates systems (origin, orientation) is also established. This relation may be needed if additional scans are required later--it permits precise patient repositioning within the diagnostic machine coordinate
system.
The scans, stereotaxic coordinates and patient and scanner coordinate systems relation are then transferred to the treatment planning computer. That planning computer is then used to develop an optimal treatment strategy (radiation beam modality
and energy, field size, treatment technique, fractionation, etc.) and finally to compute the distribution of the dose (energy absorbed) throughout the volume of interest and in particular within the lesion itself.
The treatment plan is computed in the patient coordinate system which is determined by the stereotaxic guide. The patient is ten moved to a treatment device and is secured, by means of the same halo and same base unit, to the couch of the
treatment machine in the same manner as previously secured to the couch of the diagnostic equipment. A magnetic field sensor is secured into the patient halo and a magnetic field source is attached to the treatment machine. Both the sensor and source
are then connected through a three dimensional converter to a control computer. The probe senses (digitizes) the magnetic field generated by the source in real time and thus the probe's coordinates (x, y, z, azimuth, elevation, and roll) are
continuously displayed on the control computer in the treatment room.
The coordinate system of the control computer is then established by positioning the field sensor into the treatment device isocenter (the point in space around which the radiation source rotates) and assigning the isocenter as the origin. The
orientation of the control computer and treatment device coordinate systems is then adjusted to coincide. Since the stereotaxic coordinates of the lesion and the probe are already known, the patient is then setup in space in a manner so that the control
computer reads the lesion coordinates as previously determined but now transferred into the coordinate system of the treatment machine.
Verification films are then taken and the six coordinates are recorded. The control computer, which may be portable, is transferred to the outside of the room and is then used to monitor patient motion during treatment. Patient setup for
subsequent treatments is done in the same manner using the six stereotaxic coordinates and the control computer. By means of providing information about patient and machine relative positions, an accidental collision during treatment may be avoided.
Since there is no need to remove the halo from the head of the patient during treatment, the halo typically remains on the patient's head during the entire series of treatments (several weeks) and, together with the control computer, allows the
accurate alignment of the radiation beam of the treatment machine to the desired lesion treatment coordinates.
The stereotaxic guide, through its stereotaxic phantom cage and halo attached to the cranium (bone fixation), determines the patient coordinate system (CS) including the origin and orientation. From the CT or MR scans, the stereotaxic
coordinates of the lesion and field sensor are determined in the patient CS. At the same time, the relation between the patient's and diagnostic unit coordinate systems is established. The data, meaning the scans, the lesion and probe coordinates and
relation between patient CS and diagnostic machine CS are transferred into the treatment planning computer. The treatment plan/strategy is computed in the patient CS.
The patient is moved into the treatment room with halo and field probe attached and a low frequency magnetic field is generated by the source secured to the treatment machine. Both the probe and the source are connected via a converter to the
control computer. The probe digitizes the 3D space field in real-time. The probe (and consequently the halo, and consequently the patient and hence the lesion) position (x, y, z) and space orientation (azimuth, elevation, roll) are instantly displayed
on the control computer in the treatment room. The coordinate system of the control computer, that is, the origin and orientation of the magnetic field CS, is established in such a manner, that the origin is set to be the treatment machine isocenter and
its orientation is made to coordinate with the treatment machine CS.
The stereotaxic coordinates of the lesion and the probe are then recomputed (transferred) from the patient CS into the control computer (and hence the treatment machine) coordinate system. The patient is then manipulated in space until the
control computer displays the transferred stereotaxic coordinates of the lesion. Subsequent patient setup for additional treatments is done in the same manner.
During the actual treatment, the control portable computer is placed outside of the room and is used to monitor patient motion during the treatment session. If the motion is excessive, the treatment can be interrupted. Furthermore, the control
computer provides continuous information concerning the relative position of the patient (field probe) and treatment machine (field source). That data may be used to halt the machine motion if that motion would result in a machine-patient collision. It
should be noted that for the majority of patients, the treatment technique of choice is a "moving beam therapy" meaning that during the treatment the treatment machine rotates around the lesion (patient).
If any re-planning or additional scanning needs to be done--as long as the patient has the halo attached--the patient can be precisely repositioned in the diagnostic machine CS because the relation between the patient and diagnostic machine
coordinate systems is already known.
With these and other objects, advantages and features of the invention that may become hereinafter apparent, the nature of the invention may be more clearly understood by reference to the following detailed description of the invention, the
appended claims, and to the several drawings attached herein.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is an electrical block diagram showing some of the electronic equipment utilized with the apparatus of the present invention;
FIG. 2 is a perspective drawing of the mechanical system of the present invention;
FIG. 3a is a perspective drawing of the base support of the present invention;
FIG. 3b is a drawing of the top view of the base support of the present invention;
FIG. 3c is a side drawing of the side view of the base support of the present invention; and
FIG. 3d is a drawing of the base support taken through the lines A--A' of FIG. 3a;
FIG. 4a is a drawing of a perspective view of the base used with the present invention;
FIG. 4b is a drawing of a top view of the base used with the present invention; and
FIG. 4c is a drawing of the side view of the base used with the present invention;
FIG. 5a is a drawing of the perspective view of the gyro assembly used with the present invention;
FIG. 5b is a drawing of the front view of the gyro assembly used with the present invention;
FIG. 5c is a drawing of a side view of the gyro assembly used with the present invention; and
FIG. 5d is a drawing of a side view of the gyro assembly used with the present invention showing the gyro elevation and azimuth motions;
FIG. 6a is drawing of a perspective view of the halo assembly used with the present invention;
FIG. 6b is a drawing of the front view of the halo support which forms part of the halo assembly shown in FIG. 6a;
FIG. 6c is a drawing of a front view of the halo which forms part of the halo assembly shown in FIG. 6a; and
FIG. 6d is a drawing of the side view of the halo assembly shown in FIG. 6a; and
FIG. 7a is a drawing of a perspective view of the stereotaxic coordinates phantom or cage used with the mechanical system of the present invention;
FIG. 7b is a drawing of the front view of the phantom or cage shown in FIG. 7a; and
FIG. 7c is a drawing of the side view of the phantom or cage shown in FIG. 7a; and
FIG. 8 is a drawing showing the interrelationship between the mechanical and computer systems which together form the treatment device portion of the computer controlled stereotaxic radiotherapy system of the present invention.
DETAILED
DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring now in detail to the drawings wherein like parts are designated by like reference numerals throughout, there is illustrated in FIG. 1 a schematic block diagram of a portion of the computer system utilized with the computer controlled
stereotaxic radiotherapy system of the present invention. A CT scanner 2, such as a General Electric Model 8800 or 9800, is used together with the mechanical assemblies of the present invention, as shown, for example, in FIG. 2 and as will be described
later herein, to produce the scans and associated tumor coordinates of a patient having, for example, a brain lesion. The CT scanner 2 may also be used in conjunction with a three-dimensional digitizer device and accompanying software, such as the
3Space Three-Dimensional Digitizer available from Polhemus Navigation Sciences Division of McDonald Douglas Electronics Company, Colchester, Vt. 05446.
The tumor and probe coordinates are transferred to the treatment planning computer 4, which may be, for example, an IBM-PC or AT class or one of the DEC-VAX family of computers, where the treatment plan is designed, using treatment planning
software, for example, General Electric Target or Therplan software by Theratronix. Further, the treatment computer 4 has in its memory the radiation beam data from the relevant treatment device 6 (shown in FIG. 8).
The three-dimensional digitizer utilizes magnetic transducing technology to precisely measure the x, y and z position of the tumor, as will be described later in more detail, as well as the three orientation angles of the digitizer stylus or
probe itself. The 3Space Three-Dimensional Digitizer is provided with a system electronics unit which includes the hardware and software necessary to control the digitizer elements and to interface with the host computer, such as the control computer 8,
utilized in the present invention, a probe or stylus that houses a magnetic-field sensor which is used to designate the point to be digitized, such as the isocenter of the treatment machine, and a low-frequency magnetic field device which is mounted in
the vicinity of the probe, for example, to the treatment machine 6 to which the probe is referenced in space.
Referring now to FIG. 2, there is shown the mechanical assembly 10 utilized as part of the inventive computer controlled stereotaxic radiotherapy system. The mechanical assembly 10 includes a base assembly 11 formed of a base 12 which is movably
secured to a base support 14. Attached to the rear portion 28 of the base 12 is a gyro assembly mounting element 24 to which the halo support 16 and attached halo 18 are releasably mounted. Removably attached to the rear 28 of the base 12 is a
stereotaxic coordinates phantom or cage 20 which contains a different contrast material, depending upon whether the cage or phantom 20 is used with a CT scanner or a magnetic resonance imaging (MRI) machine. A field sensor or probe 22, such as that
previously described as part of the 3Space Three-Dimensional Digitizer system is removably mounted to the stereotaxic coordinates phantom or cage 20. A probe phantom with no metal coils inside is used in MR scanner.
Referring now to FIGS. 3a-3d, there are shown drawings of the base support 14 for use with the present invention. The base support 14 is attached to the treatment couches of both the CT scanner 2 and the treatment device 6, which may be a linear
accelerator such as the Toshiba Model LMR13 or Varian Model 2500C. By utilizing the same base support 14 secured in the same position on the treatment couches of both the CT scanner and linear accelerator, the system of the present invention is able to
automatically correlate the precise coordinates of the lesion. It is also necessary to the success of the present invention, of course, that the halo 18 together with the halo support 16 be affixed to the portion of the patient's body to be treated,
such as the head, and to remain fixed in that same position throughout the course of treatment to be administered to the patient. Skin piercing screws with pins which are secured into the bone (cranium) are used.
The base support 14 is fixed to the couch of the CT scanner 2 and to the treatment couch 80 of the treatment machine 6 by any suitable means, such as by the peg 23 with interlocking mechanism (not shown) shown in FIG. 3c. The base support 14 is
provided with a plurality of bar-like elements 26 to which the base 12 may be movably affixed, in order to provide for movement in the transverse direction of the treatment couch. In that manner, the couch can always be centrally located and collisions
between the moving accelerator 6 and stationary couch 80 can be avoided--at least in the base arc.
Although only two bar-like elements 26 are shown, it is of course well known in the art that any type and number of elements may be utilized to accomplish the alignment process described above; the only requirements being that the base 12 be able
to be movably attached to the base support 14 in a simple and easy to accomplish manner. It should also be noted that the entire base assembly 11 may be constructed from any non-magnetic material, such as DELRIN (acetal resin) available from COMCO
Corporation.
FIGS. 4a-4c show details of the base 12 which may be of a T-shaped configuration. The crosspiece 28 of the base 12 may contain a locking member 30 having a locking lever 32 to receive the gyro assembly 24. A plurality of lock members 36, of any
suitable type, may be utilized to secure the base 12 relative to the base support 14 and to allow movement between the base 12 and the base support 14 in a direction perpendicular to the longitudinal axis of the treatment couch 80. As shown in FIGS. 4a
and 4c, a plurality of fingers 38 are utilized to secure the base 12 to the base support 14 and at the same time to provide for the positioning of the base 12 with respect to the treatment sides of the couch 80. The crosspiece portion 28 of the T-shaped
base 12 also includes a pair of locator elements 39 which may be, for example, pins or holes, for precisely locating the stereotaxic coordinate phantom 20 to the base 12.
FIGS. 5a-5d show details of the gyro assembly 24 which is secured to the base 12 by means of the gyro lock 30. The gyro 24 includes a shaft 50 which is secured within the gyro lock 30. As shown in FIGS. 5a-5d, the shaft 50 may be partially
split such that it is more securely removably attached to the base 12 by means of the gyro lock 30 and locking lever 32 (shown in FIGS. 4a-4b). The purpose of the gyro lock 30 is to provide rotation of the halo 18 and halo support 16, which is secured
to the top of the gyro assembly 24 by means of the slot 52 and halo lock 54 about the y axis, as well as to provide adjustment of the attached halo 18 in the azimuth and elevation angles. In order to more securely affix the halo support 16 and attached
halo 18 to the gyro assembly 24, a halo locating pin 56 is provided within the slot 52 located at the top of the gyro assembly 24. A gyro ring 58 is provided with which to easily rotate the gyro assembly 24 about the y axis of the base 12, which is also
the y axis of the treatment couch 80. The gyro ring 58 also facilitates gyro motion in the y direction.
As discussed above, the gyro assembly 24 also provides or elevation motion. A tongue 63 and groove 65 structure as shown in FIG. 5b is provided and is secured by means of an elevation motion lock 60. When the elevation motion lock 60 is
released, the elevation angle of the gyro assembly 24 may be modified and then a new elevation angle secured, again by means of the elevation motion lock 60. A modification of the gyro elevation angle is shown in FIG. 5d.
The gyro assembly 24 also includes a supporting member 67 which provides additional support to the halo support 16 inserted into the slot 52 after being aligned with the halo locating pin 56 contained at the top of the gyro assembly 24. The gyro
assembly 24, as well as the halo 18 and halo support 16 and base assembly 11, may all be preferably formed from non-magnetic material. Such material includes plastic, such as DELRIN (acetal resin) with titanium hardware.
FIGS. 6a-6d show the halo 18 and halo support 16. As shown in FIG. 6b, the halo support 16 is of a generally U-shaped configuration. At the base of the halo support 16 is a tab 68 which is used to secure to the halo support to the gyro assembly
24.
As shown in FIG. 6c, the halo 18 is formed as an elongated circle, for use in treating a cranial lesion. Obviously, the halo may be of a somewhat modified shape if the system of the present invention is used, for example, to treat a patient's
prostate. The halo 18 is formed as a single ring of non-magnetic material, such as DELRIN (acetal resin) which contains titanium inserts 61. The halo is secured to the skull of a patient to be treated by means of titanium skin piercing screws 62.
Different inserts may be utilized for different patients as determined, e.g., by the position of a previous craniotomy, etc. The halo itself can be either of a standard size or a custom size if required, e.g., a pediatric halo.
The halo 18 is attached to the patient after a local anesthesia is injected into the skull of the patient in the places where the four screws 62 will be attached. Once the halo 18 is applied, and the titanium screws 62 tightened, only the tip of
each screw 62 engages in the skull, with about 7 pounds per square inch of force. Since the halo | | |
