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Pharmaceutically useful furo[3,2-c]pyridines
   
Document Number
US Patent 5109008
Issued Date
April 28, 1992
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Abstract
Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents hydrogen, unsubstituted or substituted C.sub.1-6 alkyl, halogen, --COR.sub.4 or --CO.sub.2 R.sub.4 (where R.sub.4 represents hydrogen or unsubstituted or substituted C.sub.1-6 alkyl); R.sub.2 and R.sub.3 are the same or different and are C.sub.1-6 alkyl or C.sub.3-6 alkenyl; or --NR.sub.2 R.sub.3 forms a 5-membered (optionally containing an oxygen atom adjacent to the nitrogen) or a 6-membered ring, which ring optionally contains one unit of unsaturation and which is unsubstituted or substituted by hydroxy, C.sub.1-6 acyloxy, oxo, optionally substituted methylidene, --COR.sub.5 (where R.sub.5 represents C.sub.1-6 alkyl, OR.sub.6 or --NHR.sub.6, and R.sub.6 represents hydrogen, C.sub.1-6 alkyl, aryl or ar(C.sub.1-6)alkyl) or said ring is substituted by .dbd.NOR.sub.7 (where R.sub.7 represents C.sub.1-6 alkyl); Z represents --O-- or --S--; X represents a direct bond, --CH.sub.2 -- or --CH.sub.2 O--; Ar represents a substituted phenyl moiety; and pharmaceutically acceptable salts thereof. The compounds are indicated as useful in the treatment of pain and cerebral ischaemia. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed.
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Number of Claims:
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Owner
Glaxo Group Limited (London,GB2)
Published
April 28, 1992
Application Number
07/423,202
Filed
October 18, 1989
US Classification
514/302   546/114 546/115 546/116
Int'l Classification
C07D   491/00   (20060101)   C07D   495/00   (20060101)   C07D   495/04   (20060101)   C07D   491/04   (20060101)  
Examiner
Attorney/Law Firm
Priority Data
Oct 18, 1988 [GB] 8824400
USPTO Field of Search
546/114   546/115   546/116   514/301   514/302  
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