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Lung sound detection system and method    

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United States Patent5165417   
Link to this pagehttp://www.wikipatents.com/5165417.html
Inventor(s)Murphy, Jr.; Raymond L. H. (38 Cypress Rd., Wellesley, MA 02181)
AbstractA system and method for automatically detecting an adventitious sound from a sound signal formed of a plurality of successive sound waves received from a patient including establishing at least one of a predetermined time interval and a threshold signal value based on an average signal value of at least a portion of a sound signal, sequentially comparing the sound waves to at least one of the threshold signal value and the predetermined time interval to identify a first wave having at least one of an amplitude at least as large as the threshold signal value and a duration falling within the predetermined time interval, and identifying an adventitious sound when at least one consecutive wave following the first wave has at least one of an amplitude at least as large as the threshold signal value and a duration falling within the predetermined time interval.
   














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Drawing from US Patent 5165417
Lung sound detection system and method - US Patent 5165417 Drawing
Lung sound detection system and method
Inventor     Murphy, Jr.; Raymond L. H. (38 Cypress Rd., Wellesley, MA 02181)
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Publication Date     November 24, 1992
Application Number     07/406,152
PAIR File History     Application Data   Transaction History
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Filing Date     September 12, 1989
US Classification     600/529 181/126 181/131 381/67 600/586
Int'l Classification     A61B 007/00
Examiner     Shay; David M.
Assistant Examiner    
Attorney/Law Firm     Iandiorio & Dingman
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USPTO Field of Search     128/773 128/774 128/780 128/782 128/700 128/710 128/716 181/126 181/131 381/67
Patent Tags     lung sound detection
   
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Mar,1980

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What is claimed is:

1. A system for automatically detecting an adventitious sound from a sound signal formed of a plurality of successive sound waves received from a patient, comprising:

means for sequentially comparing the individual sound waves of at least a portion of the sound signal with a first predetermined time interval to identify an initial deflection wave having a duration falling within said first predetermined time interval; and

means, responsive to said means for comparing, for identifying an adventitious sound occurring within said sound signal when each of from 2-16 consecutive sound waves following said initial deflection wave has a duration falling within a second predetermined time interval.

2. A system for automatically detecting an adventitious sound in a sound signal formed of a plurality of successive sound waves received from a patient, comprising:

means for establishing at least one of a predetermined time interval and a threshold signal value based on an average signal value of at least a portion of said sound signal;

means, responsive to said means for establishing, for sequentially comparing said sound waves to at least one of said threshold signal value and said predetermined time interval to identify a first wave having at least one of an amplitude at least as large as said threshold signal value and a duration falling within said predetermined time interval;

means, responsive to said means for sequentially comparing, for identifying an adventitious sound when at least one consecutive wave following said first wave has at least one of an amplitude at least as large as said threshold signal value and a duration falling within said predetermined time interval; and

means for conditioning said sound signal to attenuate normal sounds, including a filter for attenuating sound signals having frequency lower then approximately 80 hertz and greater than approximately 2000 hertz.

3. The system of claim 2 in which said means for conditioning includes means for digitizing said sound signal.

4. The system of claim 2 in which said means for conditioning includes means for amplifying said sound signal.

5. The system of claim 2 in which said means for conditioning includes means for storing a sample sound signal.

6. The system of claim 5 in which said sample sound signal includes an analog sound signal sample.

7. A system for automatically detecting an adventitious sound in a sound signal formed of a plurality of successive sound waves received from a patient, comprising:

means for establishing at least one of a predetermined time interval and a threshold signal value based on an average signal value of at least a portion of said sound signal;

means, responsive to said means for establishing, for sequentially comparing said sound waves to at least one of said threshold signal value and said predetermined time interval to identify a first wave having at least one of an amplitude at least as large as said threshold signal value and a duration falling within said predetermined time interval;

means, responsive to said means for sequentially comparing, for identifying an adventitious sound when at least one consecutive wave following said first wave has at least one of an amplitude at least as large as said threshold signal value and a duration falling within said predetermined time interval; and

means, responsive to said means for identifying, for determining the type of adventitious sound occurring in said sound signal.

8. The system of claim 7 in which said means for determining includes means for establishing the duration of the adventitious sound.

9. The system of claim 8 in which said means for determining further includes means, responsive to said means for establishing, for identifying a squeak or squawk if said adventitious sound duration is between 25 and 250 milliseconds.

10. The system of claim 8 in which said means for determining further includes means, responsive to said means for establishing, for identifying a wheeze or rhonchus if said adventitious sound duration is greater than 250 milliseconds.

11. The system of claim 8 in which said means for determining further includes means, responsive to said means for establishing, for identifying a crackle if said adventitious sound duration is less than 25 milliseconds.

12. A system for automatically detecting an adventitious sound from a sound signal formed of a plurality of successive sound waves received from a patient, comprising:

means for determining an average signal value of at least a portion of said sound signal;

means for generating a threshold value based on said average signal value;

means for sequentially comparing the sound waves of at least a portion of the sound signal with a predetermined time interval to identify an initial deflection wave having a duration falling within said time interval;

means, responsive to said means for sequentially comparing, for sequentially comparing the amplitude of individual sound waves following said initial deflection wave to said threshold value;

means, responsive to said means for sequentially comparing sound waves amplitude for identifying an adventitious sound occurring within the sound signal when each of a plurality of consecutive sound waves following said initial deflection wave has an amplitude at least as large as said threshold value; and

means for determining the initial slope of the wave following said initial deflection wave.

13. The system of claim 12 further including means, responsive to said means for determining the initial slope, for comparing the initial slope with a predetermined slope range to identify a wave following said initial deflection wave having an initial slope falling within the slope range.

14. The system of claim 13 in which said means for identifying is further responsive to said means for comparing the initial slope for identifying an adventitious sound only when the initial slope of the wave following said initial deflection wave is within said slope range.

15. A system for automatically detecting an adventitious sound signal formed of a plurality of successive sound waves required from a patient, comprising:

means for establishing and a threshold signal value based on an average signal value of at least a portion of said sound signal;

means, responsive to said means for establishing, for sequentially comparing said sound waves to at least one of said threshold signal value and said predetermined time interval to identify a first wave having at least one of an amplitude at least as large as said threshold signal value and a duration falling within said predetermined timer interval;

means, responsive to said means for sequentially comparing, for identifying an adventitious sound when at least one consecutive wave following said first wave has at least one of an amplitude at least as large as said threshold signal value and a duration falling within said predetermined timer interval; and

means, responsive to said means for identifying, for determining the number of lung sounds in said sound signal.

16. A system for automatically detecting an adventitious sound signal formed of a plurality of successive sound waves received from a patient, comprising:

means for establishing at least one of a time interval consisting of a series of predetermined time intervals which progressively increase in duration and a threshold signal value based on an average signal value of at least a portion of said sound signal;

means, responsive to said means for establishing, for sequentially comparing said sound waves to at least one of said threshold signal value and said predetermined time interval to identify a first wave having at least one of an amplitude at least as large as said threshold signal value and a duration falling within said predetermined time interval; and

means, responsive to said means for sequentially comparing, for identifying an adventitious sound when at least one consecutive wave following said first wave has at least one of an amplitude at least as large as said threshold signal value and a duration falling within said predetermined time interval.

17. A system for automatically detecting an adventitious sound from a sound signal formed of a plurality of successive sound waves received from a patient, comprising:

means for determining an average signal value of at least a portion of said sound signal;

means for generating a threshold value based on said average signal value;

means for sequentially comparing the sound waves of at least a portion of the sound signal with a predetermined time interval to identify an initial deflection wave having a duration falling within said time interval;

means, responsive to said means for sequentially comparing, for sequentially comparing the amplitude of individual sound waves following said initial deflection wave to said threshold value;

means for comparing the total sum of waves including the initial deflection wave and the number of consecutive sound waves after said initial deflection wave having an amplitude at least at large as said threshold value to a predetermined wave count range between three to sixteen waves; and

means, responsive to said means for sequentially comparing sound wave amplitudes and responsive to said means for comparing, for identifying an adventitious sound occurring within the sound signal when each of a plurality of consecutive sound waves following said initial deflection wave has an amplitude at least as large as said threshold value and for identifying an adventitious sound only when said sum total of waves is within said predetermined wave count range.

18. A system for automatically detecting an adventitious wound from a sound signal formed of a plurality of successive sound waves received from a patient, comprising:

means for determining an average signal value of at least a portion of said sound signal;

means for generating a threshold value based on said average signal value;

means for sequentially comparing the sound waves of at least a portion of the sound signal with a predetermined time interval to identify an initial deflection wave having a duration falling within said time interval;

means, responsive to said means for sequentially comparing, for sequentially comparing the amplitude of individual sound waves following said initial deflection wave to said threshold value;

comparator means for sequentially comparing at least a portion of the sound waves following said initial deflection wave with said predetermined time interval;

counter means, responsive to said comparator means, for resolving the number of consecutive sound waves following said initial deflection wave having a duration falling within said predetermining time interval;

means for comparing the duration of said consecutive sound waves having a duration falling within said predetermined time interval to the duration of the previously occurring sound wave; and

means, responsive to said means for sequentially comparing the sound waves, responsive to said means for sequentially comparing sound waves amplitudes and responsive to said means for comparing the duration of said consecutive sound waves, for identifying an adventitious sound occurring within the sound signal when each of a plurality of consecutive sound waves following said initial deflection wave has an amplitude at least as large as said threshold value and for identifying an adventitious sound only when a plurality of successive sound waves following said initial deflection wave have progressively increasing durations.

19. A system for automatically detecting an adventitious sound from a sound signal formed of a plurality of successive sound waves received from a patient, comprising:

means for determining an average signal value of at least a portion of said sound signal;

means for generating a threshold value based on said average signal value;

means for sequentially comparing the sound waves of at least a portion of the sound signal with a predetermined time interval from between approximately 0.125 to approximately 3.0 milliseconds to identify an initial deflection wave having a duration falling within said time interval;

means, responsive to said means for sequentially comparing, for sequentially comparing the amplitude of individual sound waves following said initial deflection wave to said threshold value; and

means, responsive to said means for sequentially comparing the sound waves and sound wave amplitudes, for identifying an adventitious sound occurring within the sound signal when each of a plurality of consecutive sound waves following said initial deflection wave has an amplitude at least as large as said threshold value.
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FIELD OF INVENTION

This invention relates to a diagnostic method and apparatus for detecting breathing abnormalities in humans to diagnose lung disorders and more particularly to such an apparatus and method which automatically detects adventitious lung sounds.

BACKGROUND OF INVENTION

Listening to various adventitious or abnormal breathing sounds has proven to be an important diagnostic tool for detecting and monitoring certain types of lung diseases. Abnormal pulmonary sounds are generally detected by placing a stethoscope over selective areas of a patient's chest and listening for the sounds directly. The type of abnormal sound, its location, and its frequency of occurrence are used to make determinations of the type of disease and its severity.

The detected sounds are typically classified into normal lung sounds or adventitious (abnormal) sounds, usually divided into continuous or discontinuous sounds depending on their duration. Continuous sounds are further divided into wheezes, which are high-pitched, hissing sounds and rhonchi, which are low-pitched, snoring sounds. Discontinuous sounds are similarly divided into coarse crackles, which are short intermittent explosive sounds having a low pitch, or fine crackles, which are distinguished from coarse crackles in that they are less loud, shorter in duration, and higher in pitch. Other adventitious sounds include pleural friction rub and bronchial breathing.

Generally, it is a difficult task for an observer to detect accurately various lung sound abnormalities, since they are frequently of short duration, sometimes of relatively low amplitude, and generally mixed in with normal breathing sounds, which sometimes obscure the abnormal sounds. Furthermore, the task of classifying, quantifying and documenting lung sounds is difficult to accomplish with a stethoscope. Observers vary greatly in their abilities in this regard, making diagnosis less reliable.

An apparatus which forms visual waveforms representing the breathing sounds of a patient using a time-expanded scale has been disclosed by the present inventor in U.S. Pat. No. 3,990,435. This apparatus permits a trained observer to visually delineate the abnormal sounds from normal sounds. This has greatly improved diagnostic accuracy and helped clarify the previously confused lung sound nomenclature. Diagnosis, however, depends on the observer to properly sort and distinguish the different abnormal lung sounds from the normal lung sounds detected at various locations. The manual sorting of lung sounds visually or acoustically is a tedious task whose accuracy depends on the experience and alertness of the observer.

Another method of adventitious sound detection employs one or more bandpass filters to selectively detect sounds in preselected frequency ranges. Abnormal sound identification is based on the percentage of the total sample made up of sounds in the selected ranges. This technique is very unreliable; many of the adventitious sounds have components in the same or overlapping frequency ranges. As a result, the technique often cannot distinguish the different types of sounds, especially when more than one type is present.

SUMMARY OF INVENTION

It is therefore an object of this invention to provide a system for automatically identifying adventitious (abnormal) sounds from a patient.

It is a further object of this invention to provide a system for automatically identifying crackles, wheezes, rhonchi, squeaks and squawks.

It is a further object of this invention to provide a system for automatically counting such adventitious sounds.

This invention results from the realization that a simple, noninvasive and harmless way of analyzing illnesses associated with lung disease can be achieved by automatically identifying adventitious lung sounds in a patient by sequentially comparing each half cycle sound wave in a lung sound signal with predetermined wave duration and/or amplitude criteria to identify sounds based on a comparison of these results to expert analyses of typical sound signals of the different types of adventitious lung sounds.

This invention features a system and method for automatically detecting an adventitious sound from a sound signal formed of a plurality of successive sound waves received from a patient. The system features means for establishing at least one of a predetermined time interval and a threshold signal value based on an average signal value of at least a portion of the sound signal, and means, responsive to the means for establishing, for sequentially comparing the sound waves to at least one of the threshold signal value and the predetermined time interval to identify a first wave having at least one of an amplitude at least as large as the threshold value and a duration falling within the predetermined time interval. Further included are means, responsive to the means for sequentially comparing, for identifying an adventitious sound when at least one consecutive wave following the first wave has at least one of an amplitude at least as large as the threshold signal value and a duration falling within the predetermined time interval.

Preferably, the system includes means for receiving the sound signal from a patient, which may be accomplished with an electronic stethoscope. Also included may be means for conditioning the sound signal to attenuate normal sounds. That may be accomplished with a filter for attenuating sound signals having frequencies lower than approximately 80 hertz and greater than approximately 2000 hertz. The system may further include means for storing a sample sound signal, which may include an analog sound signal sample. The means for conditioning the sound signal may also include means for digitizing that signal. Also included may be means for amplifying the sound signal.

Preferably, the system includes means for determining an average signal value of at least a portion of the sound signal, and means for generating a threshold value based on that average value. In that embodiment, there may further be included means for sequentially comparing the sound waves with the predetermined time interval to identify an initial deflection wave having a duration falling within the time interval. Further included may be means, responsive to the means for sequentially comparing the sound waves, for sequentially comparing the sound waves following the initial deflection wave to the threshold value, and means for identifying an adventitious sound occurring within the sound signal only when a plurality of consecutive sound waves including the initial deflection wave have an amplitude at least as large as the threshold value.

The system preferably also includes means for comparing the total sum of waves including the initial deflection wave and the number of consecutive sound waves thereafter having an amplitude at least as large as the threshold value to a predetermined wave count range. In that case, the means for identifying is preferably responsive to the means for comparing the total sum of waves for identifying an adventitious sound only when the total sum of waves is within the predetermined wave count range. That wave count range is preferably from two to sixteen waves.

The system may further include means for determining the initial slope of the wave following the initial deflection wave, and means, responsive to the means for determining the initial slope, for comparing the initial slope with the predetermined slope range to identify a wave following the initial deflection wave having an initial slope falling within that slope range. In that case, the means for identifying is preferably further responsive to the means for comparing the initial slope for identifying an adventitious sound only when the initial slope of the wave following the initial deflection wave is within the slope range.

The system may also include comparator means for comparing the individual durations of at least a portion of the sound waves following the initial deflection wave with the predetermined time interval. In that case, a counter is preferably included, responsive to the comparator, for resolving the number of consecutive sound waves including the initial wave having a duration falling within the predetermined time interval. The means for identifying may then be responsive to the counter means for identifying an adventitious sound only when a plurality of consecutive sound waves have a duration falling within the predetermined time interval.

In an alternative embodiment, the system may further include means for comparing the individual durations of the consecutive sound waves having a duration falling within the predetermined time interval to the duration of the previously occurring sound wave. In that case, the means for identifying may be further responsive to the means for comparing the duration of the consecutive sound waves for identifying an adventitious sound only when a plurality of successive sound waves following the initial deflection wave have progressively increasing durations. The predetermined time interval may be from approximately 0.125 to approximately 3.0 milliseconds. The system may identify the sound based on overall duration; a crackle lasting less than 25 milliseconds; a squeak or squawk lasting from 25 to 250 milliseconds; and a wheeze or rhonchus lasting more than 250 milliseconds. The other identification criteria may also be employed to further differentiate the type of adventitious sound.

DISCLOSURE OF PREFERRED EMBODIMENT

Other objects, features and advantages will occur to one skilled in the art from the following description of a preferred embodiment and the accompanying drawings, in which:

FIG. 1 is a waveform illustrating an abnormal lung sound illustrative of an adventitious sound detected by the system of this invention;

FIGS. 2A, 2B, 2C, 3A, 3B, 3C, 4A and 4B are flowcharts illustrating the operation of the system according to this invention;

FIG. 5 is a simplified schematic diagram illustrating a system according to this invention for automatically identifying an adventitious lung sound in a patient;

FIG. 6 is a more detailed schematic diagram of the system of FIG. 5 featuring the signal conditioner;

FIG. 7 is a more detailed schematic diagram of the system of FIG. 5 detailing the detection module; and

FIGS. 8A, B and C are plots of the relative wave amplitude distributions in a normal lung sound, crackle and rhonchus, respectively, illustrating the amplitude detection method of adventitious lung sound identification according to this invention.

A lung sound detection system according to this invention automatically detects an adventitious sound from a sound signal received from a patient consisting of a number of sequential sound waves. An adventitious sound is identified from information derived from the durations of the individual sound waves or their amplitudes, or both. In one embodiment, when a preselected number of consecutive waves in the sound signal meet the established duration and/or amplitude parameters, the group of waves is identified as an adventitious sound. Preferably, an entire sound signal consisting of at least one inspiration and expiration cycle is checked in this manner, and the number and type of adventitious sounds occurring in the sound signal is determined.

There are many types of adventitious sounds which may be identified by the system and method according to this invention. Adventitious sound identification has always been an important diagnostic tool. However, until recently, uniform standards for identifying adventitious sounds did not exist. In U.S. Pat. No. 3,990,435, incorporated herein by reference, some of those different types of adventitious sounds were shown and described. The sounds called rales in that patent are now known as crackles. The different types of adventitious sounds have historically been identified by the physician using a stethoscope. In the referenced U.S. patent, a breath sound diagnostic apparatus was disclosed which visually displayed on a time-expanded scale a representation of lung sounds. That apparatus provided practitioners the ability to visually identify adventitious sounds.

The commonly occurring adventitious sounds may be briefly described as follows. Crackles are typically artifacts having a duration of less than twenty-five milliseconds. A crackle typically includes from two to sixteen consecutive half cycle sound waves each having a duration of from approximately 0.125 to approximately 3.0 milliseconds. Coarse crackles are relatively loud and low-pitched; fine crackles are softer, shorter, higher-pitched sounds. The durations of the half cycle waves in a crackle typically increase as the event progresses.

A wheeze is typically a continuous, high pitched polyphonic musical sound lasting at least 250 milliseconds. The sound may have two predominant frequencies, one centered between 350 and 500 Hz, and the other below that. The half cycle sound waves are typically relatively uniform throughout the artifact. A rhonchus is typically a continuous low pitched, snoring sound which is visually similar to a wheeze, with a duration of at least 250 milliseconds. The primary difference between the wheeze and rhonchus is the frequency; the rhonchus typically is monophonic, with a predominant frequency below 350 Hz. Squeaks and squawks are short high pitched chirping sounds with typical durations between twenty-five and 250 milliseconds. Visually, the wave form is relatively uniform. Thus, the system and method of this invention also contemplates identification based on sequential comparison of individual sound wave durations to establishd duration criteria based on the dominant frequencies or overall sound duration.

A further identification factor may be based on an analysis of the distribution of the half cycle sound wave amplitudes occurring in the sound signal. Normal lung sounds have a relatively random amplitude distribution. The wave amplitude distribution in a crackle has been found to be relatively narrow; the majority of the waves have similar amplitudes. On the other hand, the amplitude distribution in a typical rhonchus is wide; there are relatively even numbers of waves having several different amplitudes. Adventitious sound identification based on the amplitude distribution criteria may be used alone or in conjunction with one or more of the other criteria.

This invention thus provides for automatic identification of adventitious sounds based on the amplitude and/or duration of the half cycle sound waves forming the sound, as well as the overall duration of the artifact itself. The system and method of this invention provides the flexibility for identification based on these factors in accordance with established definitions of adventitious sounds.

In a preferred embodiment, a crackle is identified as follows: an average value of the sound signal is determined and a threshold value is generated from that average value. The individual sound waves of the sound signal are then compared to a predetermined time interval to detect an initial deflection wave having a duration falling within that interval. Once an initial deflection wave is identified, the lung sound detection system sequentially analyzes the sound waves immediately following the initial deflection wave to identify the adventitious sound.

In this preferred embodiment, the initial slope of the wave immediately following the initial deflection wave is preferably determined. The initial slope is defined as a slope of the wave immediately after the first zero crossing. If the slope is within a predetermined range of slopes, the system continues the analysis. If the slope does not fall within the selected range, the system returns to the duration analysis, looking for the next initial deflection wave.

When the slope is within the preselected range, the system determines the number of sequential waves following the initial deflection wave meeting established duration and amplitude criteria. A wave is identified as potentially part of an adventitious sound when it has an amplitude at least as large as the preestablished threshold value and a duration falling within the preselected range. The duration of each wave is also compared to the duration of the immediately preceding wave; a wave is identified as being potentially part of an adventitious sound only when its duration is greater than that of the preceding wave, as long as its duration stays within the preselected duration range.

The sound is then identified as a crackle by comparing the number of sequential waves having the established criteria to a preselected wave count. For example, the system may be enabled to identify a portion of the sound signal as a crackle when the number of consecutive waves including the initial deflection wave meeting the established criteria is between two and sixteen. If the number is less than two or greater than sixteen, the system does not identify the group of waves as a crackle and the operation returns to wave analysis for identification of the next initial deflection wave. Alternatively, the sequential wave count may continue for identification of continuous sounds. For example, the sound may be a wheeze or rhonchus if there are at least seventeen consecutive waves meeting the criteria. For continuous sounds, increasing duration is typically not used as a criterion. The system may then distinguish the specific type of continuous sound based on other criteria.

Adventitious sounds may be identified in other manners as is more fully described below. The above description of a preferred embodiment is simply one example of a rigorous sound signal analysis for adventitious sound identification.

There is shown in FIG. 1 an example of a portion 39 of a sound signal received from a patient. The portion includes successive half-cycle sound waves 40, 41, 46 and 47. Portion 39 illustrates a crackle; waves 40, 41, 46 and 47 are sequential waves which meet the criteria established for identification of such an adventitious sound. Wave 40 is an initial deflection wave, which is identified as a wave having a duration falling within a predetermined time interval. The duration of the wave is defined as the time between zero crossings, established by line 45.

After the identification of initial deflection wave 40, the system preferably determines initial slope 44 of next wave 41. The system identifies wave 41 as potentially belonging to an adventitious sound when its duration, or time between zero crossings, T.sub.2 -T.sub.1, falls within the predetermined range of durations. Alternatively, wave 41 may be identified when its amplitude is at least as large as previously established threshold value 42. For waves in the opposite direction, threshold value 43 having the same absolute value as threshold value 42 is established.

The duration and/or amplitude of successive waves is then compared to the preestablished criteria for determination of the number of consecutive waves having those criteria. Additionally, the system may compare the durations of the successive waves and identify a wave only when its duration is greater than the previous wave in the group identified as a potential adventitious sound. When the number of consecutive waves identified is at least two and no more than sixteen, the system identifies the wave group as a crackle. The analysis then continues with the next wave after the adventitious sound to look for the next initial deflection wave. Preferably, the system scans the entire sound signal in this manner and determines the number and type of adventitious sounds for use by the physician in diagnosis.

Flow charts for embodiments of the system and method according to this invention are shown in FIGS. 2 through 4. In one embodiment, FIG. 2A, adventitious sounds such as crackles are identified by first selecting a sample of a predetermined duration from the sound signal, step 100. The sample duration may be a portion of or an entire inspiration and expiration cycle, or more than one such cycle. The sample average is determined, step 102, preferably as the root mean square of the signal value. The root means square is preferably the square root of the average square of the instantaneous magnitude of the voltages. This average value is then used to establish threshold values, step 104. As an example, threshold value that are plus and minus three times the average value have been found to be useful for identifying crackles. The threshold value may be established based on the operator experience, and previous patient history.

The system then compares sequentially the half cycle sound waves of the sample to the threshold values, step 105. If the wave amplitude is as large as a threshold, the system moves on to step 110, in which wave counter N is incremented. If N is greater than 16, N is reset, step 115. If N is not greater than 16, operation proceeds to an amplitude review of the next wave, steps 106 and 105. If the amplitude is not as large as the threshold, operation proceeds to step 112.

The total number N of consecutive waves including the first wave satisfying the identification criterion forms in this example the basis for identification. As a non-limiting example, to identify a crackle, N may be chosen as between 2 and 16. The number employed is based on expert evaluation of visual representations of an adventitious sound identified as a crackle. If N is greater than 16, the group of waves is not a crackle and operation returns to step 106 through step 115. If N is less than 16, and greater than 2, the crackle counter is incremented, step 114, the wave counter is reset, step 115, and operation returns to step 106 for analysis of the remainder of the sample.

Two additional steps which may be added to the flow chart of FIG. 2A are shown in FIG. 2B. After a first wave having at least the threshold amplitude is identified, step 105, operation may continue to step 115 for a determination of the initial slope of the next wave. If slope S is between 375 and 400, as is more fully described below in conjunction with FIG. 7, the operation continues to step 110. Preferably, only the initial slope of the wave immediately following the first wave identified in step 105 is checked. Thus, steps 115 and 116 would be passed through only once--immediately after initial wave identification. After that, the system checks only the wave amplitude as described above in conjunction with FIG. 2A.

Another set of steps which may be added to the flow chart of FIG. 2A is shown in FIG. 2C. After the number N of waves satisfying the amplitude criterion are counted, step 112, operation may continue to step 200 for amplitude comparison range setting. Step 200 may comprise reading comparison ranges from a lookup table or allowing the operator to set the ranges as desired. The amplitude ranges may be established by plotting the number of waves having given amplitudes as is more fully described below in conjunction with FIGS. 8A through 8C. The result is similar to an expert system in that the system and method according to this invention may compare the wave amplitude distribution to that known to exist for the different types of adventitious sounds to identify the occurrence of that type of sound. Operation proceeds to step 202 in which the system determines the wave amplitudes and step 204 in which the determined amplitudes are compared to the established comparison ranges. The result is similar in effect to plotting the amplitude ranges as shown below.

In identification of crackles, step 206 is included for comparison of the wave distribution to that of a typical crackle. It should be understood that for identification of other types of adventitious sounds, the comparison may be made to known amplitude distributions for each of the types of adventitious sounds. The artifact may then be identified by comparison of the amplitude distributions to those established amplitude distributions. At step 206, if the distribution is more similar to crackle distribution, operation proceeds to step 114. If not, operation proceeds to step 115. For a system in which something other than a crackle, or more than just a crackle, is being monitored, rather than proceeding to step 115, the operation could proceed to additional steps similar to step 206 for a comparison of the wave distribution range to distributions for other types of adventitious sounds, for example, wheezes, rhonchi, squeaks and squawks.

A flow chart for an alternative embodiment of the adventitious sound identification system is shown in FIGS. 3A, 3B and 3C. System 119 sequentially compares wave durations to a selected time interval and determines the number of sequential waves having a duration falling within that interval to identify an adventitious sound. After selection of a time interval for comparison to wave durations, step 120, operation proceeds to step 122, in which the wave durations are sequentially compared to the selected time interval. When a first wave having a duration within that range is found, operation continues to step 126, in which counter N is incremented. If N is not greater than 16, step 124, the monitoring loop continues through step 123. Steps 122, 126, 124 and 123 thus provide sequential wave duration monitoring. If the number of successive waves having a duration within the predetermined range of durations is greater than sixteen, step 124, the group is not a crackle and operation returns to step 123 through step 129 to begin looking for the next initial deflection wave.

After the sequential identification of a number N of waves having the established duration, operation continues to step 128. If N is greater than or equal to two or less than or equal to sixteen, the crackle counter is incremented, step 130, counter N is reset, step 129, and operation continues, step 123, for identification of the remainder of the crackles in the sound sample. If N does not fall within this range, the group of waves is not identified as a crackle and the operation continues by resetting the counter, step 129, moving to the next wave, step 123, and looking for the next initial deflection wave, step 122.

FIG. 3B illustrates an additional two steps which may be added to the embodiment of FIG. 3A for identifying waves only if their durations progressively increase. Steps 125 and 127 may be added after step 122 for incrementing wave counter N after identification of the first or initial deflection wave only if the duration of the wave is greater than the previous wave duration. This provides the further limitation that the waves of the adventitious sound must progressively increase in duration.

FIG. 3C illustrates steps which may be added to the embodiment of FIG. 3A for identifying an adventitious sound (in this case a crackle) only if the artifact duration is within set duration parameters. After identification of N waves potentially comprising a crackle, step 128, operation would proceed to step 131, in which the duration parameters for the different types of adventitious sounds would be set by the operator or retrieved from a preestablished memory location. Duration ranges for some of the types of adventitious sounds have been detailed above.

In step 132, the artifact duration is determined, and compared to the established artifact duration parameters, step 134. In this example, only crackles are being monitored. However, typically the system and method of this invention contemplate monitoring for numerous types of advantitious sounds; in that case, steps similar to step 134 would be added for comparison of the established artifact duration to the duration parameters for the other types of adventitious sounds. Operation then proceeds to step 129 if the duration is not in the desired range, or step 130 if it is.

The dominant frequency may also be used as a means of identification, preferably together with the overall sound duration. The frequency is determined using the half-cycle duration criteria by, for example, setting a minimum and maximum individual wave duration window for sequential wave comparison. For example, to count waves having a frequency of less than 350 hertz, the duration parameters are set as greater than approximatly 1.4 milliseconds per half cycle. For 350-500 hertz, the duration must be between approximately 1.0 and 1.4 milliseconds. Using the frequency criterion, one may distinguish between squeaks and squawks as a first, high-pitched group, and wheeezes and rhonchi as a second, low-pitched group. Wheezes and rhonchi may be individually distinguished based on the existence of two dominant frequencies in a wheeze; while both have a dominant frequency between 0-350 hertz, the wheeze has a second sound or note between approximately 350-500 hertz. These measurements, together with the overall duration based on number of consecutive waves, provide a further means of identifying the several types of adventitious sounds.

FIGS. 4A and 4B illustrate a flow chart of an embodiment of the present invention in which adventitious sounds are identified by comparison of the individual sound waves of the sound signal to several of the parameters which form a part of this invention. The operator selects a wave count range for identification of an adventitious sound, step 149, time interval for comparison to the wave duration, step 150, and a slope range for the initial slope of the wave following the initial deflection wave, step 151. The operator also selects the sample size, step 160. After a determination of an average value of the sample, step 162, the threshold values are set, step 164, in response to a selection of the threshold parameter, step 163. The individual waves of the sound signal