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Wholly microfabricated biosensors and process for the manufacture and use thereof    
United States Patent5200051   
Link to this pagehttp://www.wikipatents.com/5200051.html
Inventor(s)Cozzette; Stephen N. (Nepean, CA); Davis; Graham (Plainsboro, NJ); Itak; Jeanne A. (North Brunswick, NJ); Lauks; Imants R. (Yardley, PA); Mier; Randall M. (Morrisville, PA); Piznik; Sylvia (Jackson, NJ); Smit; Nicolaas (Hightstown, NJ); Steiner; Susan J. (Trenton, NJ); Van Der Werf; Paul (Princeton Junction, NJ); Wieck; Henry J. (Plainsboro, NJ)
AbstractAn efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.



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Drawing from US Patent 5200051
Wholly microfabricated biosensors and process for the manufacture and use thereof - US Patent 5200051 Drawing
Wholly microfabricated biosensors and process for the manufacture and use thereof
Inventor     Cozzette; Stephen N. (Nepean, CA); Davis; Graham (Plainsboro, NJ); Itak; Jeanne A. (North Brunswick, NJ); Lauks; Imants R. (Yardley, PA); Mier; Randall M. (Morrisville, PA); Piznik; Sylvia (Jackson, NJ); Smit; Nicolaas (Hightstown, NJ); Steiner; Susan J. (Trenton, NJ); Van Der Werf; Paul (Princeton Junction, NJ); Wieck; Henry J. (Plainsboro, NJ)
Owner/Assignee     I-Stat Corporation (Princeton, NJ)
Patent assignment
All assignments
Publication Date     April 6, 1993
Application Number     07/432,714
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     November 7, 1989
US Classification     204/403.07 204/403.09 204/403.1 204/403.11 204/403.13 204/415 205/778 205/782.5 257/253 422/930 435/287.9
Int'l Classification     G01N 027/26
Examiner     Niebling; John
Assistant Examiner     Bell; Bruce F.
Attorney/Law Firm     Pennie & Edmonds
Address
Parent Case     CROSS REFERENCE TO RELATED APPLICATION The present application is a continuation-in-part of prior co-pending U.S. application Ser. No. 07/381,223, filed Jul. 13, 1989, now abandoned which, in turn is a continuation-in-part of prior co-pending U.S. application Ser. No. 07/270,171, filed Nov. 14, 1988, now abandoned. The disclosures of both prior applications are incorporated by reference herein.
Priority Data    
USPTO Field of Search     204/415 204/403 204/153.12 204/153.17 435/291 435/288 435/817
Patent Tags     wholly microfabricated biosensors manufacture and
   
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