Biocompatible device with covalently bonded biocompatible agent

Claims

What is claimed is:

1. A biocompatible device comprising a solid surface carrying molecules of a carbohydrate capable of existing in contact with biological fluid or tissue of a living organism with a net beneficial effect on the organism, and a chemical linking moiety residue covalently binding individual molecules of the carbohydrate to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the carbohydrate, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the carbohydrate are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

2. A biocompatible device comprising a solid surface carrying molecules of a fatty acid capable of existing in contact with biological fluid or tissue of a living organism with a net beneficial effect on the organism, and a chemical linking moiety residue covalently binding individual molecules of the fatty acid to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the fatty acid, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the fatty acid are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

3. A biocompatible opthalmic lens having a solid surface, molecules of a synthetic hydrophilic polymer and a chemical linking moiety residue linking individual molecules of the synthetic hydrophilic polymer to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the synthetic hydrophilic polymer, one of the groups being unresponsive to a stimulus to which the other reactive group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the synthetic hydrophilic polymer are positioned sufficiently proximate to one another as to cause said molecules to effective shield the solid surface and to provide a biocompatible effective surface.

4. Vascular graft tubing having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

5. Vascular graft tubing according to claim 4 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.

6. A dialysis membrane having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

7. A dialysis membrane according to claim 6 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.

8. A catheter having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

9. A catheter according to claim 8 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.

10. An intraaortic balloon catheter having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

11. An intraaortic balloon catheter according to claim 10 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.

12. A suture having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

13. A suture according to claim 12 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.

14. A soft tissue prosthesis having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

15. A soft tissue prosthesis according to claim 14 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.

16. A hard tissue prosthesis having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

17. A hard tissue prosthesis according to claim 16 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.

18. An artificial organ, having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.

19. An artificial organ according to claim 18 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.

20. An opthalmic lens having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chem