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Techniques for enhancing the permeability of ions through membranes
   
Document Number
US Patent 5312534
Issued Date
May 17, 1994
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Inventors
[*] (Notice:The portion of the term of this patent subsequent to October 22, 2008 has been disclaimed.)
Map
Abstract
A method is provided for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane located in a space subjected to a local magnetic field. The space defines at least one reference path passing through the membrane in opposite first and second directions. The method includes the steps of creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending in the first direction along the path. This component of the magnetic field has a magnitude that fluctuates at a predetermined rate to produce a nonzero average value. A predetermined relationship between the ratio of the selected rate to the nonzero average value and the charge-to-mass ratio of the predetermined ion is thereby created. The predetermined relationship, is a function of the cyclotron resonance frequency of the ion. The present invention also provides an apparatus for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane. The apparatus includes field creating means responsive to signals for creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending along a path through the membrane and having a magnitude that fluctuates at a predetermined rate to create a nonzero average value. The ratio of the predetermined rate to the nonzero average value has a predetermined relationship with respect to the charge-to-mass ratio of the predetermined ion which is a function of the cyclotron resonance frequency of the ion. Signal generating means is provided for generating the signals, at least some of which are generated at the predetermined rate.
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Techniques for enhancing the permeability of ions through membranes - US Patent 5312534 Drawing
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Number of Claims:
20
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Owner
Published
May 17, 1994
Application Number
07/280,848
Filed
December 7, 1988
US Classification
435/285.2   204/155 204/157.15 204/193 435/173.5
Int'l Classification
A61N   2/02   (20060101)   C12N   13/00   (20060101)   A61N   1/32   (20060101)   A61N   2/00   (20060101)  
Examiner
Assistant Examiner
Parent Case
This is a continuation of co-pending application Ser. No. 06/923,760 filed on Oct. 27, 1986 now U.S. Pat. No. 4,818,697 issued Apr. 4, 1989.
USPTO Field of Search
435/173   204/157.15   204/155   204/193   204/299R  
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