A method of inhibiting the growth of multidrug resistant cancer cells which comprises contacting multidrug resistant cancer cells with an effective amount of a flavonoid compound. Also, a composition for inhibiting the growth of multidrug resistant cancer cells which comprises a physiologically acceptable carrier and an amount of a flavonoid compound.
Compositions and methods for the prevention and treatment of neoplastic diseases are described. Individuals at a high risk of developing or having neoplasia undergoing conventional therapies may be treated with an effective dose of triterpene derivatives in limonoids, polyphenolic flavonoid compounds, tocotrienols or a combination of these agents.
A method of inhibiting the production of cytokines, particularly inhibiting the production of tumor necrosis factor.alpha., interleukin-10, and macrophage inflammatory protein-1.alpha. and the like, in a mammal, including a human, in need thereof which involves administering to such mammal an effective amount, preferably cytokine production inhibiting amount, of a polymethoxylated flavone.
Substituted heterocyclic compounds for treating multidrug resistance are disclosed. Compositions and methods of use for the substituted heterocyclic compounds are disclosed. Suitable substituted heterocyclic compounds include: ##STR1##
Substituted heterocyclinc compounds are disclosed. The compounds are useful for treating multidrug resistance. The compounds can be formulated in compositions with a carrier and, optionally, a therapeutic agent. One suitable substituted heterocyclic compound has the formula: ##STR00001##
