Disclosed are a novel class of anti-androgenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, according to the following formula: wherein R.sub.1 and R.sub.2 are each either hydrogen or a halogen; wherein a and c are integers from 0-9; wherein b is an integer from 1-6, provided that Also disclose are methods of synthesis of these compounds, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of known compounds not previously known for their anti-androgenic activity in treating disorders related to androgenic activities.
CROSS-REFERENCED AND RELATED APPLICATION
This application is a continuation-in-part application of U.S. patent application Ser. No. 07/889,589, filed May 27, 1992, now abandoned, the disclosure of which is incorporated herein by reference.
A cosmetic-pharmaceutical composition for topical use against human alopecia containing a pool of enzymes of the specific hydroxisteroido-dehydrogenase group in the presence of nicotinamido-adenine-dinucleotide coenzyme and a vasodilator, the whole being complexed with phospholipids in solution.
A cosmetic method for treating aged, wrinkled and/or photodamaged skin is provided through topical application of a composition which comprises petroselinic acid and/or derivatives thereof. The method also reduces skin irritation and also lightens the color of skin.
A composition for use in sculpturing, a sculpturing piece comprising the composition and a method for obtaining the piece, wherein the composition comprises 90 to 99% of a particulate material consisting of particles having a size from 0.05 to 2 mm, and a plastic binder from 1 to 10% by weight based on the total weight of the composition, each particle of the particulate material being encapsulated by a film layer of the plastic binder.
