A fiberoptic diffuser for photodynamic therapy applications comprises an optical fiber having a light transmitting core, cladding about the core, and a buffer layer about the cladding. The distal end portion of the fiber core is free from the cladding and buffer layer, and the exposed distal end of the core has a conical configuration. A cap extends about the distal end portion of the fiber and has a spheroidal end portion of light diffusing material which extends about the exposed conical end of the fiber core. The cap also has a mounting portion engaged with the buffer layer of the fiber, and it provides a cavity in which the exposed core is disposed. Light rays passing through the fiber to its distal end are refracted outwardly at the conical end of the core into the spheroidal end portion of the cap and are further refracted by the cap to exit therefrom over substantially the entire surface of the spheroidal end portion.
An optical working shaft system. The system includes a working shaft for insertion into a working tube of at least one of an endoscope and a catheter. The working shaft has a distal end defining a distal area in a vicinity thereof, and further includes: a device for radiating optical beams through the distal end; and a fluid for scattering the beams at least in the distal area. The fluid is operatively associated with the device for radiating such that, at least in the distal area, a path of the beams extends inside the fluid, the fluid further being effective as a coolant for removing waste heat generated by a scattering of the beams in the distal area.
A low-profile, diffusive tip apparatus adapted for insertion into a body to deliver phototherapeutic radiation by scattering light in a substantially omnidirectional pattern includes a light-transmissive housing that is adapted for mounting, at its proximal end, onto a fiber optic cable, and, at its distal end, the housing defines or is joined to a light-transmissive cap having a diameter which is not substantially greater than the diameter of the optical fiber. The light transmissive cap region encloses a chamber or reservoir filled with an optically scattering medium and, preferably, hemispherical in shape with a radius of curvature substantially equal to the radius of the housing.
An active endoscopic system is disclosed containing an electromagnetic radiation system located at the distal end of the endoscopic device allowing for variable intensity application of desired wavelengths in the application of PhotoDynamic Therapy (PDT) over a broad area. The power sources are varied according to the needs of a specific application. Various attachments and configurations may be used to enhance performance of a desired application, including but not limited to multi-balloon systems for centering the apparatus or limiting the treatment area, fiber optics for directly viewing the treatment area, vacuum systems for waste removal, tubes for delivering aminolevulinic acid (ALA) or other photosensitizers, and other fiber optics for illumination of treatment area. A preferred embodiment for PDT employs a multitude of low wattage diodes at the distal end of the endoscope, a scattering glass, cooling channel, external cooling unit, an inflatable balloon with a reflective surface and a tube connected to an external pump for the delivery and removal of photosensitizers. Each diode is selected to emit the respective frequency needed to activate the selected photosensitizer. Alternatively, a range of diodes may be selected to maximize the activation of the photosensitizer. Other embodiments include a chemiluminescent light source at the distal end of the endoscope. Other electromagnetic sources include microwave or radio frequency devices. The prime benefit of this system is the placement of the radiation source at the distal end of the device to bring the light source directly to the desired site.
This is a procedure for stabilizing or filling an aneurysm in the vasculature. The procedure involves the introduction into the aneurysm of a solid vaso-occlusive device such as a coil or braid and a polymeric composition which may be reformed or solidified in situ. The solid vaso-occlusive device is at least partially surrounded or enveloped by that polymeric composition. The polymeric composition is reformed via light, heat, R.F. or the like to form a rigid mass with the solid vaso-occlusive device. These steps may be carried out sequentially or the steps of introducing the vaso-occlusive device and reforming the polymeric composition may be carried out simultaneously. The procedure may be accomplished using intravascular catheters to access the desired site and to deliver the noted materials.
This is a procedure for stabilizing or filling an aneurysm in the vasculature. The procedure involves the introduction into the aneurysm of a solid vaso-occlusive device such as a coil or braid and a polymeric composition which may be reformed or solidified in situ. The solid vaso-occlusive device is at least partially surrounded or enveloped by that polymeric composition. The polymeric composition is reformed via light, heat, R.F. or the like to form a rigid mass with the solid vaso-occlusive device. These steps may be carried out sequentially or the steps of introducing the vaso-occlusive device and reforming the polymeric composition may be carried out simultaneously. The procedure may be accomplished using intravascular catheters to access the desired site and to deliver the noted materials.
