New anticonvulsant compounds include (.+-.)-2-hydroxy-2-phenylbutyramide and (.+-.)-3-hydroxy-3-phenylpentamide. These homologues of (.+-.)-4-hydroxy-4-phenylhexanamide have anticonvulsant activity as well as unexpected properties, particularly low neurotoxicity and pharmacological differences. The invention further provides methods for the synthesis of (.+-.)-2-hydroxy-2-phenylbutyramide and (.+-.)-3-hydroxy-3-phenylpentamide as exemplified in the examples.
The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis.
