Method and apparatus for ultrasonic wave medical treatment using computed tomography

What is claimed is:

1. An ultrasonic medical treatment apparatus, comprising:

ultrasonic wave applicator means for applying ultrasonic waves to an object to be treated;

non-ultrasonic computed tomography means for obtaining three-dimensional image information of the object to be treated;

focal point control means for changing a position of a focal point of the ultrasonic waves applied by the ultrasonic wave applicator means without changing a view field of the computed tomography means;

calculating means for determining the position of the focal point changed by the focal point control means in the three-dimensional image information obtained by the computed tomography means; and

display means for displaying the three-dimensional image information obtained by the computed tomography means in superposition with the focal point at the position determined by the calculation means.

2. The apparatus of claim 1, wherein the computed tomography means comprises a nuclear magnetic resonance imaging device taking T2 weighted tomographic images before and after an application of the ultrasonic waves by the ultrasonic wave applicator means, the calculation means calculates a difference image between the T2 weighted tomographic images taken by the computed tomography means before and after the application of the ultrasonic waves by the ultrasonic wave applicator means, and the display means displays the difference image calculated by the calculation means.

3. The apparatus of claim 1, wherein the computed tomography means comprises a nuclear magnetic resonance imaging device for also taking chemical shift data before and after an application of the ultrasonic waves by the ultrasonic wave applicator means, the calculation means also calculates a difference image between the chemical shift data taken by the computed tomography means before and after the application of the ultrasonic waves by the ultrasonic wave applicator means, and the display means also displays the difference image calculated by the calculation means.

4. The apparatus of claim 1, wherein the display means displays an incidence route of the ultrasonic waves applied by the ultrasonic wave applicator means in superposition to the three-dimensional image information.

5. The apparatus of claim 1, further comprising:

ultrasonic wave probe means, provided in conjunction with the ultrasonic wave applicator means, for collecting ultrasonic wave image data of the object to be treated; and

ultrasound tomographic imaging means for obtaining ultrasound tomographic images of the object to be treated from the ultrasonic wave image data collected by the ultrasonic wave probe means, wherein the display means displays the ultrasound tomographic images obtained by the ultrasound tomographic imaging means.

6. The apparatus of claim 5, wherein the display means displays a slice region currently scanned by the ultrasonic wave probe means in superposition to the three-dimensional image information.

7. The apparatus of claim 5, wherein the computed tomography means obtains two-dimensional tomographic images of the object to be treated, and the display means displays the ultrasound tomographic images obtained by the ultrasound tomographic imaging means in real time, along with corresponding views of the two-dimensional tomographic images obtained by the computed tomography means.

8. The apparatus of claim 1, wherein the computed tomography means comprises a nuclear magnetic resonance imaging device, and the apparatus further comprising endocavitary probe means to be inserted into a body cavity of the object to be treated, containing an RF coil for applying RF pulses and collecting nuclear magnetic resonance signals to be used by the computed tomography means.

9. The apparatus of claim 8, wherein the endocavitary probe means includes a temperature sensor means for measuring temperature at a position of the endocavitary probe means and intensity sensor means for measuring intensity of the ultrasonic waves applied by the ultrasonic wave applicator means at a position of the endocavitary probe means.

10. The apparatus of claim 1, wherein the focal point control means sequentially shifts the focal point of the ultrasonic waves among divided portions of the object to be treated in an order in which no two successive positions of the focal point are located at adjacent ones of the divided portions.

11. A method of ultrasonic medical treatment, comprising the steps of:

applying ultrasonic waves to an object to be treated from an ultrasonic wave applicator device;

obtaining three-dimensional image information of the object to be treated by a non-ultrasonic computed tomography device;

changing a position of a focal point of the ultrasonic waves applied at the applying step without changing a view field of the computed tomography device;

determining the position of the focal point changed at the changing step in the three-dimensional image information obtained by the computed tomography device; and

displaying the three-dimensional image information obtained by the computed tomography device in superposition with the focal point at the position determined at the determining step.

12. The method of claim 11, wherein the computed tomography device comprises a nuclear magnetic resonance imaging device, and the method further comprising the steps of:

taking T2 weighted tomographic images by the nuclear magnetic resonance imaging device before and after an application of the ultrasonic waves at the applying step;

calculating a difference image between the T2 weighted tomographic images taken by the nuclear magnetic resonance imaging device before and after the application of the ultrasonic waves at the applying step; and

displaying the difference image calculated at the calculating step.

13. The method of claim 11, wherein the computed tomography device comprises a nuclear magnetic resonance imaging device, and the method further comprising the steps of:

taking chemical shift data by the nuclear magnetic resonance imaging device before and after an application of the ultrasonic waves at the applying step;

calculating a difference image between the chemical shift data taken by the nuclear magnetic resonance imaging device before and after the application of the ultrasonic waves at the applying step; and

displaying the difference image calculated at the calculating step.

14. The method of claim 11, wherein at the displaying step, an incidence route of the ultrasonic waves applied at the applying step is also displayed in superposition to the three-dimensional image information.

15. The method of claim 11, further comprising the steps of:

collecting ultrasonic wave image data of the object to be treated by ultrasonic wave probe means;

obtaining ultrasound tomographic images of the object to be treated by ultrasound tomographic imaging means from the ultrasonic wave image data collected by the ultrasonic wave probe means; and

displaying the ultrasound tomographic images obtained by the ultrasound tomographic imaging means.

16. The method of claim 15, wherein at the step of displaying the three-dimensional image information, a slice region currently scanned by the ultrasonic wave probe means is also displayed in superposition to the three-dimensional image information.

17. The method of claim 15, further comprising the steps of:

obtaining two-dimensional tomographic images of the object to be treated by the computed tomography device; and

displaying the ultrasound tomographic images obtained by the ultrasound tomographic imaging means in real time, along with corresponding views of the two-dimensional tomographic images obtained by the computed tomography device.

18. The method of claim 11, wherein the computed tomography device comprises a nuclear magnetic resonance imaging device, and the method further comprising the step of inserting endocavitary probe means into a body cavity of the object to be treated, the endocavitary probe means containing an RF coil for applying RF pulses and collecting nuclear magnetic resonance signals to be used by the computed tomography device at the step of obtaining the three-dimensional image information.

19. The method of claim 18, further comprising the steps of:

measuring temperature at a position of the endocavitary probe means by temperature sensor means provided on the endocavitary probe means; and

measuring intensity of the ultrasonic waves applied at the applying step at the position of the endocavitary probe means by intensity sensor means provided on the endocavitary probe means.

20. The method of claim 11, wherein at the changing step, the focal point of the ultrasonic waves is sequentially changed among divided portions of the object to be treated in an order in which no two successive positions of the focal point are located at adjacent ones of the divided portions.

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BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to an ultrasonic wave medical treatment for treating treatment targets such as tumors, calculi, etc. inside a living body by applying ultrasonic waves thereon.

2. Description of the Background Art

In recent years, for a treatment of the calculosis, much attention has been attracted to a lithotriptor for destroying calculi inside a living body non-invasively by applying intense ultrasonic waves focused on the calculi to be destroyed in the living body.

For a source of the intense ultrasonic waves to be used in such a lithotriptor, there are many conventionally known sources including a source using a spark discharge in water, a source using an electromagnetic induction, a source using a small scale explosion, and a source using piezoelectric elements, each of which has its own advantages and disadvantages. Among them, the source using piezoelectric elements is known to have the disadvantage that the intensity of the ultrasonic waves at the focal point is rather small, but this type of source is also known to have several excellent advantages including the smallness of the size of the focal point, the elimination of the consumption, the controllability of the intense ultrasonic waves, the controllability of the position and the shape of the focal point by phase controlling the driving waveforms to be applied to a plurality of piezoelectric elements. (See, Japanese Patent Application Laid Open No. 60-145131. U.S. Pat. No. 4,526,168, and Japanese Patent Application Laid Open No. 62-42773.)

On the other hand, for a treatment of cancer, much attention has been attracted to a hyperthermia treatment which treats the cancer by utilizing the fact that the tumor tissues have higher thermal sensitivity than the normal tissues such that they can be killed by heating them at the temperature higher than 42.5.degree. C. In such a hyperthermia, the localized heating of the tumor portion is known to be particularly effective.

For a heating method to be used in such a hyperthermia, the method utilizing the electromagnetic waves such as microwaves has been used conventionally. However, this conventional method of heating has a difficulty in selectively heating the tumor located deep inside the living body because of the electrical characteristics of the living body that affect the penetration of the electromagnetic waves, so that the satisfactory level of treatment has been realized only for the relatively superficial tumors located within 5 cm from the surface of the living body.

For this reason, for a treatment of the deeply located tumors, there has been a proposition to use a heating method utilizing the acoustic energy such as ultrasonic waves which utilizes the fact that the ultrasonic waves have superior focusing ability as well as deeper penetration range.

There is also a proposition for a treatment method in which the above described hyperthermia is further developed to burn the tumor tissues to death by heating the tumor portion at the temperature higher than 80.degree. C., as disclosed in Japanese Patent Application No. 3-306106.

For a source of the ultrasonic waves to be used in such a hyperthermia using the ultrasonic waves, the conventionally proposed sources include an ultrasonic transducer constructed from a plurality of piezoelectric elements which has an overall spherical surface, and an annular array ultrasonic transducer constructed by arranging a plurality of ring shaped ultrasonic transducer elements concentrically. Among them, the annular array ultrasonic transducer has the advantage that the depth of the focal point can be varied electrically.

There is also a proposition for the phased array ultrasonic transducer in which the position of the focal point can be moved three-dimensionally, as disclosed in U.S. Pat. No. 4,526,168.

There is also a proposition for the treatment apparatus in which the above described lithotriptor is provided along the above described hyperthermia integrally, as disclosed in Japanese Patent Application No. 3-306106.

There is also a proposition for a hyperthermia treatment apparatus incorporating an ultrasonic wave source using piezoelectric elements in which the treatment target portion can be heated uniformly by utilizing the small focal point characteristic to the ultrasonic wave source using piezoelectric elements, as disclosed in Japanese Patent Application Laid Open No. 61-209643.

However, in this hyperthermia treatment apparatus, the focal point is moved continuously such that the ultrasonic waves are applied to neighboring regions sequentially. Consequently, it has been impossible in this hyperthermia treatment apparatus to carry out the treatment procedure including the application of the ultrasonic waves to two distanced points alternately or the avoidance of obstacles such as bones during the application of the ultrasonic waves, so that there is a danger of damaging the normal tissues in vicinities of the tumor tissues.

Moreover, in a case of applying the intense ultrasonic waves continuously at a fixed target position, the acoustic energy released immediately after the start of the application of the ultrasonic waves can reach to the target position without any obstruction, but the acoustic energy reaching to the target position will be gradually attenuated as air bubbles generated at or in vicinity of the focal point due to the cavitation caused by the intense ultrasonic waves themselves start to reflect the intense ultrasonic waves. The same problem due to the cavitation is also present in a case of applying the intense ultrasonic waves by moving the focal point slowly.

Here, the cavitation is the phenomenon in which the air bubbles (air cavities) are generated by tearing off the water through which the intense ultrasonic waves pass, as a very large tensile force is exerted to the water due to the influence of the negative pressure associated with the intense ultrasonic waves passing through the water. The air bubbles so generated will subsequently function as reflectors for the ultrasonic waves. Consequently, when a large amount of air bubbles generated by the cavitation are floating around the previous focal points to which the intense ultrasonic waves have already been applied, the acoustic energy of the intense ultrasonic waves applied to a new focal point in a vicinity of the previous focal points will be attenuated.

On the other hand, in a conventional hyperthermia treatment apparatus, the positioning of the focal point is achieved by utilizing the two-dimensional ultrasound tomographic images. However, the tumor to be treated very often has a complicated three-dimensional shape in practice, so that it has been very difficult to realize the complete treatment of the entire tumor by using the two-dimensional tomographic images.

To cope with this problem, there has been a proposition to utilize the three-dimensional ultrasound images, as disclosed in Japanese Patent Application Laid Open No. 61-209643.

However, in the ultrasound images, the region behind the bones and the pneumatic organs such as a lung becomes invisible, so that the full three-dimensional information cannot be provided, and only the relative position of the focal point and the treatment target portion can be ascertained at best.

Furthermore, such a conventional hyperthermia treatment apparatus has no means to judge the effect of the treatment made, so that whether to continue or discontinue the treatment cannot be decided over a considerably long period of time ranging from several weeks to several months required to ascertain the effect of the treatment by some conventionally known methods.

Moreover, it has been difficult in the conventional hyperthermia treatment apparatus to accurately determine the temperature at which the tumor portion is actually heated, so that it has been difficult to prevent the accidental overlooking of some tumor portions to be treated or the excessive heating of some portions to which the intense ultrasonic waves are applied.

SUMMARY OF THE INVENTION

It is, therefore, an object of the present invention to provide a method and an apparatus for an ultrasonic wave medical treatment capable of determining the position of the focal point of the ultrasonic waves easily and accurately.

It is another object of the present invention to provide a method and an apparatus for an ultrasonic wave medical treatment capable of determining the effect of the treatment easily and accurately, shortly after the treatment has actually been made.

It is another object of the present invention to provide a method and an apparatus for an ultrasonic wave medical treatment capable of determining the temperature in a vicinity of the object to be treated easily and accurately, such that the effective treatment of the tumor tissues can be realized without any potential for damaging the normal tissues around the tumor tissues.

According to one aspect of the present invention there is provided an ultrasonic medical treatment apparatus, comprising: ultrasonic wave applicator means for applying ultrasonic waves to an object to be treated; focal point control means for changing a focal point of the ultrasonic waves applied by the ultrasonic wave applicator means; computed tomography means for obtaining three-dimensional image information of the object to be treated; calculation means for determining a position of the focal point changed by the focal point control means in the three-dimensional image information obtained by the computed tomography means; and display means for displaying the three-dimensional image information obtained by the computed tomography means in superposition with the focal point at the position determined by the calculation means.

According to another aspect of the present invention there is provided a method of ultrasonic medical treatment, comprising the steps of: applying ultrasonic waves to an object to be treated with an ultrasonic wave applicator means; changing a focal point of the ultrasonic waves applied at the applying step; obtaining three-dimensional image information of the object to be treated by computed tomography means; determining a position of the focal point changed at the changing step in the three-dimensional image information obtained by the computed tomography means; and displaying the three-dimensional image information obtained by the computed tomography means in superposition with the focal point at the position determined at the determining step.

Other features and advantages of the present invention will become apparent from the following description taken in conjunction with the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic block diagram of a first embodiment of an ultrasonic wave medical treatment apparatus according to the present invention.

FIG. 2 is a schematic block diagram of a second embodiment of an ultrasonic wave medical treatment apparatus according to the present invention.

FIG. 3 is a perspective view of a phased array ultrasonic transducer to be used in the ultrasonic wave medical treatment apparatus shown in FIG. 2.

FIG. 4 is an illustration of an exemplary display to be used in the ultrasonic wave medical treatment apparatus shown in FIG. 2.

FIG. 5 is a schematic diagram of an alternative spatial arrangement of a static magnetic field coil and gradient magnetic field coils in a CT section of the ultrasonic wave medical treatment apparatus of FIG. 2.

FIG. 6 is an illustration of an exemplary display to be used in a third embodiment of the ultrasonic wave medical treatment apparatus according to the present invention, at a time of entering the ultrasonic wave treatment plan.

FIG. 7 is an illustration of an exemplary display to be used in a third embodiment of the ultrasonic wave medical treatment apparatus according to the present invention, at a time of executing the ultrasonic wave treatment.

FIG. 8 is a diagrammatic illustration of positioning of a phased array ultrasonic wave transducer and an endocavitary probe to be used in a fourth embodiment of the ultrasonic wave medical treatment apparatus according to the present invention.

FIG. 9 is an enlarged view of the endocavitary probe shown in FIG. 8 to be used in a fourth embodiment of the ultrasonic wave medical treatment apparatus according to the present invention.

FIG. 10 is a schematic block diagram of a main part of a fifth embodiment of an ultrasonic wave medical treatment apparatus according to the present invention.

FIG. 11A is an illustration of an exemplary display to be used in the ultrasonic wave medical treatment apparatus of FIG. 10.

FIG. 11B is an illustration of contours of a tumor to be used in constructing a three-dimensional image information in the exemplary display of FIG. 11A.

FIG. 12A and FIG. 12B are diagrammatic illustration of measurements of maximum lengths in three orthogonal directions to be utilized in obtaining an alternative three-dimensional image information to be displayed in the ultrasonic wave medical treatment apparatus of FIG. 10.

FIG. 12C is an illustration of the alternative three-dimensional image information to be displayed in the ultrasonic wave medical treatment apparatus of FIG. 10 obtained from the measurements made in FIG. 12A and FIG. 12B.

FIG. 13A and FIG. 13B are illustrations of division of a tumor into cells to be utilized in the application of the intense ultrasonic waves in the ultrasonic wave medical treatment apparatus of FIG. 10.

FIG. 14 is an illustration of the divided cells of a tumor for explaining an order of application of the intense ultrasonic waves in the ultrasonic wave medical treatment apparatus of FIG. 10.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Referring now to FIG. 1, a first embodiment of an ultrasonic wave medical treatment apparatus according to the present invention will be described in detail.

In this first embodiment, the ultrasonic wave medical treatment apparatus generally comprises an ultrasonic wave treatment section, and a computed tomography (CT) section.

The ultrasonic wave treatment section includes: an ultrasonic wave applicator 1 constructed from an ultrasonic transducer 2 having a spherical surface for generating intense ultrasonic waves to be applied to a patient 3, an acoustic coupling fluid 4 for transmitting the intense ultrasonic waves generated by the ultrasonic transducer 2 to the patient 3, and a water bag 5 for containing the acoustic coupling fluid 4; a driving circuit unit 108 for driving the ultrasonic transducer 2 to generate the intense ultrasonic waves of a desired intensity; a mechanical arm unit 18 for controlling a position of the ultrasonic wave applicator 1 with respect to the patient 3; and an applicator position detection unit 19 for detecting a position of the ultrasonic wave applicator 1 controlled by the mechanical arm unit 18 by using potentiometers (not shown) attached on the mechanical arm unit 18.

In a case of applying the intense ultrasonic waves to the patient 3, the ultrasonic wave applicator 1 is placed on the body surface of the patient 3 with the water bag 5 facing toward the patient 3 such that the water bag 5 can make a contact with the body surface of the patient 3 through an ultrasonic jelly (not shown) provided thereon. Then, a focal point 6 of the intense ultrasonic waves to be generated by the ultrasonic transducer 2 is positioned to a tumor 7 to be treated inside the body of the patient 3. Then, the driving circuit unit 108 drives the ultrasonic transducer 2 so as to generate the intense ultrasonic waves of a desired intensity which are focused to the focal point 6 positioned at the tumor 7 such that the tumor 7 can be treated by being heated at a desired temperature.

On the other hand, in this first embodiment, the CT section comprises a nuclear magnetic resonance imaging (MRI) apparatus capable of obtaining usual nuclear magnetic resonance (NMR) tomographic images, which is constructed from a static magnetic field coil 9 with a central bore, an imaging gantry (not shown) inserted inside the central bore of the static magnetic field coil 9 which contains gradient magnetic field coils 10 and an RF coil 11 for transmitting RF pulses and receiving NMR signals, a gradient magnetic field power source 14 connected to the gradient magnetic field coils 10, and a transceiver circuit unit 15 connected to the RF coil 11.

In addition, the ultrasonic wave medical treatment apparatus of FIG. 1 further comprises: a bed 8 for placing the patient 3 lying thereon inside the imaging gantry while using the CT section and placing the patient 3 below the ultrasonic wave applicator 1 while using the ultrasonic wave treatment section; a bed control unit 13 for controlling a location of the bed 8; a control circuit unit 12 for controlling the operations of the driving circuit unit 108 and the mechanical arm unit 18 in the ultrasonic wave treatment section, the gradient magnetic field power source 14 and the transceiver circuit unit 15 in the CT section, and the bed control unit 13; an operator console 16 connected to the control circuit unit 12 for entering an ultrasonic wave treatment plan to be prepared by an operator (not shown); a CRT display 17 connected to the control circuit unit 12 for displaying various information to be utilized by the operator; and a printer 20 for printing various information to be utilized by the operator.

Now, the ultrasonic wave medical treatment apparatus of this first embodiment operates as follows.

First, the patient 3 is positioned on the bed 8 in a supine position, and carried inside the imaging gantry and set at a prescribed imaging position A by the bed 8 controlled by the bed control unit 13.

Then, the control circuit unit 12 controls the gradient magnetic field power source 14 and the transceiver circuit unit 15 according to the prescribed imaging sequence specified by the operator through the operator console 16 such that the usual multi-plane NMR tomographic images containing the tumor 7 to be treated can be obtained. The obtained NMR tomographic images are stored in a memory (not shown) provided in the control circuit unit 12.

Next, the control circuit unit 12 controls the CRT display 17 to display three-dimensional image information, constructed from the NMR tomographic images obtained by the CT section, as a static image in a suitable display format such as pseudo-three-dimensional display using wire frame.

At this point, the operator enters the ultrasonic wave treatment plan from the operator console 16 while viewing the three-dimensional image information containing the tumor 7 to be treated which is displayed on the CRT display 17. Here, the ultrasonic wave treatment plan specifies the scanning pattern for the focal point 6 and the desired intensity of the intense ultrasonic waves to be applied as well as the desired ultrasonic wave application timings and intervals and other parameters required to be specified in the ultrasonic wave treatment to be made by the ultrasonic wave treatment section. When the entering of the ultrasonic wave treatment plan is completed, the operator commands the start of the ultrasonic wave treatment from the operator console 16.

In response, the control circuit unit 12 controls the bed control unit 13 such that the bed 8 with the patient 3 lying thereon is moved to the ultrasonic wave treatment section and set to a prescribed treatment position B.

Then, the control circuit unit 12 controls the mechanical arm unit 18 such that the ultrasonic wave applicator 1 is placed on the patient 3 above the tumor 7 to be treated. During this positioning of the ultrasonic wave applicator 1, the control circuit unit 12 calculates the position of the focal point 6 of the intense ultrasonic waves to be applied according to the position of the ultrasonic wave applicator 1 detected by the applicator position detection unit 19 and a prescribed relationship between the position of the mechanical arm unit 18 and the imaging view field of the CT section, and controls the CRT display 17 to display the focal point 6 in superposition to the three-dimensional image information. In addition, the control circuit unit 12 may also calculate an incidence route of the intense ultrasonic waves such that the incidence route can also be displayed along with the focal point 6. This display of the incidence route of the intense ultrasonic waves can be useful in verifying the avoidance of obstacles in the ultrasonic wave treatment plan.

Then, after the ultrasonic wave applicator 1 is appropriately positioned on the patient 3 with the focal point 6 located at the tumor 7 to be treated as specified by the ultrasonic wave treatment plan, the control circuit unit 12 controls the driving circuit unit 108 to start the ultrasonic wave treatment.

In a middle and/or at an end of the ultrasonic wave treatment as specified by the ultrasonic wave treatment plan, the application of the intense ultrasonic waves are stopped, the ultrasonic wave applicator 1 is removed from the patient 3, and the bed 8 is moved back to the imaging position A in the CT section, in order to observe the progress and/or the effect of the ultrasonic wave treatment.

Here, the NMR tomographic images are taken again in the same manner as they were taken prior to the entering of the ultrasonic wave treatment plan, and then the NMR tomographic images taken before the ultrasonic wave treatment are compared with the NMR tomographic images taken after the ultrasonic wave treatment. For example, when the NMR tomographic images taken by the CT section are the T2 weighted images, the thermally degenerated region can be clearly visualized, so that it becomes possible for the operator to visually inspect the sufficiency of the treatment applied so far and to determine the need of the further treatment. Here, for the sake of easy visual comprehension, a difference image in which the NMR tomographic images taken after the ultrasonic wave treatment are subtracted from the NMR tomographic images taken before the ultrasonic wave treatment may be calculated by the control circuit unit 12 and displayed on the CRT display 17.

It is to be noted that any desired number of such inspections using the NMR tomographic image taking may be incorporated into the ultrasonic wave treatment plan in advance such that the NMR tomographic image taking can be made automatically at specified timings. In addition, it is also possible to automatically determine an untreated region of the tumor 7 which is not yet thermally degenerated and should be subjected to the further treatment by comparing the NMR tomographic images taken before and after the ultrasonic wave treatment, and the focal point 6 of the intense ultrasonic waves to be applied by the ultrasonic wave applicator 1 for the further treatment can be automatically set to the determined untreated region.

It is also to be noted that by taking the NMR chemical shift data before and after the ultrasonic wave treatment, it also becomes possible to determine the change of the temperature at various parts withi