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Magnetic resonance guided hyperthermia    
United States Patent5492122   
Link to this pagehttp://www.wikipatents.com/5492122.html
Inventor(s)Button; Terry (East Patchogue, NY); Barbour; Susan (Westbury, NY); Cermignani; Justine D. (Fort Salonga, NY); Crugnale; Eric (Port Jefferson, NY); McGill; Robert E. (Dix Hills, NY); Spacht; Glenn (Lloyd Neck, NY)
AbstractA hyperthermia treatment apparatus includes an annular radio frequency (RF) antenna array with bolus that is compatible with a magnetic resonance imaging (MRI) machine. Antenna elements polarized parallel to the axis of the cylinder are used for forming a Specific Absorption Ratio (SAR) map as well as for directing the energy to accomplish hyperthermia. The array may be dynamically controlled to focus energy at any specified region within the cylinder. The array is positioned inside an MRI machine and is tuned to the machine's hydrogen resonant frequency. For treatment planning, the array is employed to form an SAR map via RF current density imaging. Using this map, array phase, amplitude, and temporal weighting are optimized until the SAR maxima is congruent with the treatment volume. For treatment, RF radiation is applied to the subject to induce heating of the treatment volume using these optimal array parameters. Temperature is periodically determined via noninvasive MRI methods (i.e., diffusion imaging, T.sub.1 map, etc.) in order to obtain an image that includes isotherms from which the pattern of heating can be observed. Feedback is provided such that adjustment may be made to compensate for bioheat transfer.
   














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Magnetic resonance guided hyperthermia - US Patent 5492122 Drawing
Magnetic resonance guided hyperthermia
Inventor     Button; Terry (East Patchogue, NY); Barbour; Susan (Westbury, NY); Cermignani; Justine D. (Fort Salonga, NY); Crugnale; Eric (Port Jefferson, NY); McGill; Robert E. (Dix Hills, NY); Spacht; Glenn (Lloyd Neck, NY)
Owner/Assignee     Northrop Grumman Corporation (Los Angeles, CA)
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Publication Date     February 20, 1996
Application Number     08/228,348
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     April 15, 1994
US Classification     600/411 324/315 600/412 600/549 607/101 607/102 607/154 607/156
Int'l Classification     A61B 005/055
Examiner     Zele; Krista M.
Assistant Examiner    
Attorney/Law Firm     Hoch, Jr.; Karl J. Anderson; Terry J. ,
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Priority Data    
USPTO Field of Search     128/653.2 128/653.5 128/736 607/96 607/101 607/102 607/154 607/156 324/309 324/315 324/318 324/322
Patent Tags     magnetic resonance guided hyperthermia
   
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