According to the invention, a method is provided for disrupting the targeted lesion in skin, such as is necessary in treatment of vascular or pigmented lesions. A microplasma is generated in a target region of skin, the microplasma disrupting the skin ("plasma ablation") to enable removal of the targeted lesion. The microplasma absorbs radiation energy and expands, creating high pressure in the surrounding region which causes disruption of the targeted lesion in that region. A beam of pulsed laser radiation can be used to generate the microplasma by properly controlling the peak irradiance, the pulse duration and the focal spot size of the beam. The invention enables use of a laser having small pulse energy. A synchronized laser beam scan device can be used to scan the beam to provide a highly efficient system for rapid skin treatment.
Aging or damaged skin is treated by irradiating affected skin areas with an effective amount of visible light emanating from an optical apparatus and having a wavelength of about 400 nm to about 500 nm. A light source may be sunlight or artificial light, coherent or noncoherent, pulsed or continuous, of high or low energy, exposed generally or directed to target areas, or any combination of these. In one embodiment, light-emitting diodes are applied directly to discrete skin areas as needed as patches or thin sheets such as pliable masks. Green light (about 500 to about 590 nm) may be used as adjunct therapy with blue/violet light in some embodiments. Compositions containing compounds that enhance light penetration of the stratum corneum such as .alpha.-hydroxy acids (e.g., glycolic acid) and/or filter light may be applied to the skin prior to or during phototreatment.
There is provided an improved process and apparatus for cutting and/or fingernails. The process includes the step of providing laser radiation to cut or score the nails, and optionally cooling the site of administration of the laser beam. The nails can be coated with colored lacquers to provide a multicolored design when melted by the laser.
A method and apparatus for treating lesions and tattoos sites. The method includes the steps of irradiating said lesion by a first single pulse Q-Switched laser beam directed onto the site; and again irradiating the lesion by a second single pulse Q-Switched laser beam directed onto the same lesion site within a time interval of less than about 100 .mu.s.
A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.
A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.
