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Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control    
United States Patent5602756   
Link to this pagehttp://www.wikipatents.com/5602756.html
Inventor(s)Atwood; John G. (West Redding, CT); Mossa; Albert C. (Trumbull, CT); Goven; Lisa M. (Bridgeport, CT); Williams; Fenton (Brookfield, CT); Woudenberg; Timothy M. (Bethel, CT); Margulies; Marcel (Scarsdale, NY); Ragusa; Robert P. (Newton, CT); Leath; Richard (Berkley, CA); Miles; Clive (San Rafael, CA)
AbstractAn instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.
   














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Drawing from US Patent 5602756
Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control - US Patent 5602756 Drawing
Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
Inventor     Atwood; John G. (West Redding, CT); Mossa; Albert C. (Trumbull, CT); Goven; Lisa M. (Bridgeport, CT); Williams; Fenton (Brookfield, CT); Woudenberg; Timothy M. (Bethel, CT); Margulies; Marcel (Scarsdale, NY); Ragusa; Robert P. (Newton, CT); Leath; Richard (Berkley, CA); Miles; Clive (San Rafael, CA)
Owner/Assignee     The Perkin-Elmer Corporation (Norwalk, CT)
Patent assignment
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Publication Date     February 11, 1997
Application Number     08/569,606
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     December 8, 1995
US Classification     700/269 165/205 702/130
Int'l Classification     G06G 007/58
Examiner     Voeltz; Emanuel T.
Assistant Examiner     Shah; Kamini
Attorney/Law Firm     Fish & Richardson P.C.
Address
Parent Case     This application is a continuation of U.S. application Ser. No. 07/871,264, filed Apr. 20, 1992, is now U.S. Pat. No. 5,475,610, which is a continuation-in-part application of U.S. patent application Ser. No. 07/620,606, filed Nov. 29, 1990, by Mossa et al, now abandoned, and Ser. No. 07/670,545, filed Mar. 14, 1991, now abandoned, both of which are incorporated herein by reference. Microfiche Appendicies C-F are attached, including 10 sheets of microfiche comprising 890 frames.
Priority Data    
USPTO Field of Search     364/166 364/183 364/ 364/557 236/46 165/1 165/12 438/52
Patent Tags     thermal cycler automatic performance polymerase chain reaction close temperature control
   
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