Disclosed are a novel class of antiandrogenic compounds including saturated and unsaturated fatty acids, catechin gallates, their derivatives, and synthetic analogs, their method of synthesis, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of known compounds not previously known for their antiandrogenic activity in treating disorders related to androgenic activities and cancers.
The present invention is a continuation-in-part of U.S. Ser. No. 07/904,443, filed Jul. 1, 1992, now U.S. Pat. No. 5,422,371, which is a continuation-in-part application of U.S. Ser. No. 07/889,589 filed May 27, 1992, now abandoned; the entire text and figures of which disclosures are specifically incorporated herein by reference without disclaimer.
A method for reducing food intake in a subject and a method for reducing the levels of an endocrine in a subject comprising administering to the subject in need thereof an effective amount of a compound of the formula: ##STR1## wherein A is alkenyl, and each of R.sup.a, R.sup.b, R.sup.c and R.sup.d is herein defined.
5804567 - Method of increasing the effectiveness of anti-metabolites - Owned by Cancer Institute (Hospital), Chinese Academy of Medical Sciences (Beijing,CN) Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences (Beijing,CN) Mitsui Norin Co., Ltd. (Tokyo,JP)
A method for treating cancer in a patient by administering to a patient an nti-cancer effective amount of an anti-metabolite selected from the group consisting of 1-.beta.-arabinofuranosylcytosine and 4-amino-4-deoxy-10-methylfolic acid and an anti-oxidant effective amount of a tea polyphenol compound selected from the group consisting of a tea catechin, a theaflavin and a combination of a tea catechin and a theaflavin.
The present invention provides an antialopecia agent which is a drug for protecting, reducing or preventing alopecia frequently occurring as the side effect of anticancer agents, wherein the drug inflicts neither any pain nor unpleasantness on patients under the treatment with anticancer agents and has a high safety; and foods or beverages containing this antialopecia agent. The antialopecia agent of the present invention is characterized by containing oolong tea extract as the active ingredient.
The present invention relates to a method of inhibiting angiogenesis in mammalian tissue which comprises supplying to the tissue a composition comprising an effective amount of epigallocatechin-gallate, epicatechin gallate or a combination thereof. The method is particularly useful in the treatment of angiogenesis-related skin conditions in which the catechin is applied topically, such as the treatment of various skin cancers, psoriasis, spider veins or undereye circles.
Edible compositions containing petroselinic acid are used for the preparation of food compositions or food supplements that are used as anti-inflammatory compositions that inhibit the production of metabolites of arachidonic acid and/or reduces the formation of intracellular adhesion molecules or as anti-aging compositions with a positive impact on wrinkling, sagging, photodamaged skin, dry skin, flaky skin and age spots.
