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Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays    

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United States Patent5677196   
Link to this pagehttp://www.wikipatents.com/5677196.html
Inventor(s)Herron; James N. (Salt Lake City, UT); Christensen; Douglas A. (Salt Lake City, UT); Wang; Hsu-Kun (Salt Lake City, UT); Caldwell; Karin D. (Salt Lake City, UT); Janatova ; Vera (Prague, CS); Huang; Shao-Chie (Salt Lake City, UT)
AbstractMethods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field intensity. A preferred embodiment of the biosensor and assay method have patches of capture molecules each specific for a different analyte disposed adjacent within a single reservoir. The capture molecules are immobilized to the patches on the waveguide surface by site-specific coupling of thiol groups on the capture molecules to photo-affinity crosslinkers which in turn are coupled to the waveguide surface or to a non-specific-binding-resistant coating on the surface. The patches of different antibodies are produced by selectively irradiating a portion of the waveguide surface during the process of coupling the photo-affinity crosslinkers the selective irradiation involving a mask, a laser light source, or the like.
   














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Drawing from US Patent 5677196
Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays - US Patent 5677196 Drawing
Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
Inventor     Herron; James N. (Salt Lake City, UT); Christensen; Douglas A. (Salt Lake City, UT); Wang; Hsu-Kun (Salt Lake City, UT); Caldwell; Karin D. (Salt Lake City, UT); Janatova ; Vera (Prague, CS); Huang; Shao-Chie (Salt Lake City, UT)
Owner/Assignee     University of Utah Research Foundation (Salt Lake City, UT)
Patent assignment
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Publication Date     October 14, 1997
Application Number     08/263,522
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     June 22, 1994
US Classification     436/518 356/244 356/246 356/317 356/318 385/12 385/34 385/129 422/55 422/57 422/58 422/82.05 422/82.08 422/82.09 422/82.11 435/287.1 435/287.2 435/288.7 435/808 436/164 436/165 436/172 436/527 436/805 436/807 436/809
Int'l Classification     G01N 033/543 G01N 033/552
Examiner     Chin; Christopher L.
Assistant Examiner    
Attorney/Law Firm     Trask, Britt & Rossa
Address
Parent Case     RELATED APPLICATIONS This is a continuation-in-part of application Ser. No. 08/110,169, filed Aug. 20, 1993, now U.S. Pat. No. 5,516,703, and application Ser. No. 08/071,579, filed Jun. 2, 1993, now abandoned, which is a continuation-in-part of application Ser. No. 08/064,608, filed May 18, 1993, now U.S. Pat. No. 5,512,492.
Priority Data     May 18, 1994[MX]943673
USPTO Field of Search     422/55 422/57 422/58 422/82.05 422/82.08 422/82.09 422/82.11 435/287.1 435/287.2 435/288.4 435/288.7 435/808 436/518 436/527 436/164 436/165 436/172 436/805 436/807 436/809 356/317 356/318 356/244 356/246 385/12 385/34 385/129
Patent Tags     methods multi-analyte homogeneous fluoro-immunoassays
   
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5344784
Attridge
436/518
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