Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
PRIOR APPLICATIONS
This is a continuation-in-part of U.S. application Ser. No. 08/006,447, filed Jan. 21, 1993, now abandoned which is a continuation-in-part of U.S. application Ser. No. 815,691 filed Jan. 24, 1992, now abandoned, which is a continuation-in-part of U.S. Ser. No. 733,915 filed Jul. 22, 1991, now abandoned, which is a continuation-in-part of U.S. application Ser. No. 644,002 filed Jan. 22, 1991, issued Jan. 11, 1994 as U.S. Pat. No. 5,278,296.
Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
Substituted heterocyclic compounds for treating multidrug resistance are disclosed. Compositions and methods of use for the substituted heterocyclic compounds are disclosed. Suitable substituted heterocyclic compounds include: ##STR1##
Substituted heterocyclinc compounds are disclosed. The compounds are useful for treating multidrug resistance. The compounds can be formulated in compositions with a carrier and, optionally, a therapeutic agent. One suitable substituted heterocyclic compound has the formula: ##STR00001##
Substituted heterocyclic compounds for treating multidrug resistance are disclosed. Compositions and methods of use for the substituted heterocyclic compounds are disclosed. Suitable substituted heterocyclic compounds include: ##STR00001##
Compounds suitable for treating multidrug resistance and methods for their preparation and use are disclosed. The compounds are represented by the following formula: ##STR00001## or an optical isomer, diastereomer, enantiomer or pharmaceutically acceptable salt thereof.
