Transdermal administration of olanzapine and pharmaceutically acceptable acid addition salts thereof is described. The method involves treating an individual suffering from or susceptible to psychosis, acute mania or mild anxiety states, particularly those afflicted with schizophrenia or schizophreniform illnesses, by administering olanzapine or a salt thereof through the skin or mucosal tissue, for a time period and at an administration rate effective to alleviate the symptoms of the disease. Pharmaceutical formulations and drug delivery systems for administering olanzapine are provided as well.
A transdermal therapeutic system consisting of a backing layer, at least one active substance-containing matrix layer, which may at the same time possess pressure-sensitive adhesive properties, as well as a removable protective layer is characterized by a content of a neuroleptic, a content of at least one permeation enhancer as well as by a layer which is pressure-sensitive adhesive on the skin-facing side and based on polymers which are pure hydrocarbons.
A drug delivery device includes (a) a substantially moisture vapor permeable, liquid impermeable, flexible thermoplastic backing layer, (b) a moisture vapor permeable, flexible, oleophilic thermoplastic resin foam layer, (c) a pressure sensitive adhesive layer, and (d) a drug reservoir containing at least one hydrophilic drug composition and possessing a moisture vapor permeable, but hydrophilic drug composition impermeable, barrier layer applied to one surface thereof with the drug reservoir being applied to a portion of the adhesive layer such that the barrier layer lies between the hydrophilic drug composition and the adhesive layer thereby preventing any significant migration of the drug composition from the drug reservoir into the adhesive layer.
The present invention provides a polymer blend having: a first component of a propylene containing polymer in an amount by weight of the blend from about 25% to about 35%; a second component selected from the group consisting of polyesters, polyester elastomers, and polyurethanes, the second component present in an amount by weight of the blend of from about 35% to about 45%; and a third component of an ethylene vinyl acetate copolymer in an amount by weight of the blend from about 25% to about 35%.
The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient in a solid phase, (b) a vehicle consisting substantially of polyol fatty acid esters with a degree of esterification of over 80%, and (c) a wetting agent consisting substantially of polyol fatty acid esters with a monoester proportion of over 60%. The inventive composition is used for the systemic administration of numerous pharmacologically active ingredients, whereby the ingredients are released from the pharmaceutical composition over a period of at least 12, preferably at least 24 hours.
