A powder dispenser includes a resilient container for storing a powder and a volume of air therein. The powder has properties which enable a portion of the volume of air to fluidize a portion of the powder when the resilient container is sufficiently deformed. The dispenser has a substantially rigid conduit connected to its discharge end. The conduit provides the only fluid communication between the inside of the container and an ambient outside environment. The dispenser also has a resilient flat member connected to the outer end of the conduit. The flat member has a slit that is normally closed such that the container is substantially sealed in a fluid-tight manner until the container is sufficiently deformed to generate a pressure in the volume of air. When a pressure differential exists that is greater than a threshold value, the pressure differential causes the slit to open to discharge a portion of the powder mixed with a portion of the volume of air. The dispenser may also have an apertured member in the conduit that has at least one aperture therethrough having a total cross-sectional area smaller than a cross-sectional area of the conduit. The at least one aperture provides increased air velocity and turbulence to improve mixing of powder and air.
A nasal aspirator having a stem, a tip and a bulb. The stem having an inner lumen from a top to a bottom. The tip comprising of an aperture at a point that arches from a base, wherein the base is secured to the top of the stem. The bulb having a ribbed opening into an inner hollow cavity. The bottom of the stem being inserted through the ribbed opening and into the inner hollow cavity so that the top of the stem is secured at the ribbed opening of the bulb.
A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.
A medicament delivery device for administering a medicament to a user includes a medicament reservoir and an entrance port and an exit port each disposed adjacent the reservoir. A gas chamber disposed adjacent the entrance port. The device includes a pressurizing mechanism operable to pressurize said gas chamber to at least a prescribed pressure. A first frangible membrane extends across the entrance port and separates the reservoir from the gas chamber. A second frangible membrane extends across the exit port. When the pressurizing mechanism is attached, at least one of the first and second membranes is responsive to the prescribed pressure in the gas chamber to burst to allow gas to flow through the entrance port and the reservoir and to carry the medicament through the exit port.
A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet. The method of forming the cartridge includes stretching out and bending a membrane to one end of the cartridge, preferably by heat bonding, filling the cartridge with a medicament and sealing the opposed end preferably with a second burstable membrane by stretching out a membrane over a convex surface and heat bonding.
A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.
