June 1, 1999

The present invention provides a human histone-like protein (HLP) and polynucleotides which identify and encode HLP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for producing HTP and for treating disorders associated with the expression of HLP.

3

June 1, 1999

09/099,572

June 18, 1998

514/12   435/252.3 435/320.1 435/69.1 530/350 536/23.1 536/23.5

C07K   14/47   (20060101)   C07K   14/435   (20060101)   A61K   38/00   (20060101)  

This application is a divisional application of U.S. application Ser. No. 08/821,009, filed Mar. 19, 1997.

514/12   435/69.1   435/252.3   435/320.1   530/350   536/23.1   536/23.5  

6673623 - Methods and compositions that control lipid production - Owned by Novocure, Inc. (LaGrange, IL) The present invention relates generally to the use of lipogenins, proteins, e.g. human extra-cellular matrix protein 1 (ECM-1), human glia-derived nexin I alpha protein (NP-I), human tissue inhibitor of metalloproteinase-2 (TIMP-2) and human histone H2A (H2A) singly or in various combinations to control lipogenesis in a mammal.