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| United States Patent | 5961923 |
| Link to this page | http://www.wikipatents.com/5961923.html |
| Inventor(s) | Nova; Michael P. (Rancho Santa Fe, CA);
Parandoosh; Zahra (San Diego, CA);
Senyei; Andrew E. (La Jolla, CA);
Xiao; Xiao-Yi (San Diego, CA);
David; Gary S. (La Jolla, CA);
Satoda; Yozo (San Diego, CA);
Zhao; Chanfeng (San Diego, CA);
Potash; Hanan (La Jolla, CA) |
| Abstract | Combinations, called matrices with memories, of matrix materials that are
encoded with an optically readable code are provided. The matrix materials
are those that are used in as supports in solid phase chemical and
biochemical syntheses, immunoassays and hybridization reactions. The
matrix materials may additionally include fluophors or other luminescent
moieties to produce luminescing matrices with memories. The memories
include electronic and optical storage media and also include optical
memories, such as bar codes and other machine-readable codes. By virtue of
this combination, molecules and biological particles, such as phage and
viral particles and cells, that are in proximity or in physical contact
with the matrix combination can be labeled by programming the memory with
identifying information and can be identified by retrieving the stored
information. Combinations of matrix materials, memories, and linked
molecules and biological materials are also provided. The combinations
have a multiplicity of applications, including combinatorial chemistry,
isolation and purification of target macromolecules, capture and detection
of macromolecules for analytical purposes, selective removal of
contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical
modification and other uses. Methods for tagging molecules, biological
particles and matrix support materials, immunoassays, receptor binding
assays, scintillation proximity assays, non-radioactive proximity assays,
and other methods are also provided. |
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| Publication Date |
October 5, 1999 |
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| Filing Date |
September 30, 1996 |
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| Parent Case |
RELATED APPLICATIONS
This application is a continuation-in-part of U.S. application Ser. No.
08/709,435 entitled "MATRICES WITH MEMORIES AND USES THEREOF", filed on
Sep. 6, 1996, by Michael P. Nova, Zahra Parandoosh, Andrew E. Senyei,
Xiao-Yi Xiao, Gary S. David, Yozo Satoda, Chanfeng Zhao and Hanan Potash.
This application is also a continuation-in-part of U.S. application Ser.
No. 08/711,426 entitled "MATRICES WITH MEMORIES AND USES THEREOF", filed
on Sep. 6, 1996, by Michael P. Nova, Zahra Parandoosh, Andrew E. Senyei,
Xiao-Yi Xiao, Gary S. David, Yozo Satoda, Chanfeng Zhao and Hanan Potash.
This application is also a continuation-in-part of U.S. application Ser.
No. 08/669,252, entitled "REMOTELY PROGRAMMABLE MATRICES WITH MEMORIES AND
USES THEREOF, filed on Jun. 24, 1996, by Michael P. Nova, Andrew E.
Senyei, Zahra Parandoosh, Gary S. David, Hanan Potash and Xiao-Yi Xiao.
This application is also a continuation-in-part of U.S. application Ser.
No. 08/633,410, entitled "MATRICES WITH MEMORIES AND USES THEREOF", filed
on Jun. 10, 1996, by Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh,
Gary S. David, Hanan Potash and Xiao-Yi Xiao. This application is a
continuation-in-part of International PCT application No. PCT/US96/06145
which designates the U.S. and which was filed on Apr. 25, 1996, is also a
continuation-in-part of U.S. application Ser. No. 08/639,813, filed Apr.
2, 1996, entitled "REMOTELY PROGRAMMABLE MATRICES WITH MEMORIES AND USES
THEREOF", by Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh and Gary
S. David, abandoned, is also a continuation-in-part of U.S. application
Ser. No. 08/567,746, filed Dec. 5, 1995, entitled "REMOTELY PROGRAMMABLE
MATRICES WITH MEMORIES AND USES THEREOF", by Michael P. Nova, Andrew E.
Senyei, Zahra Parandoosh and Gary S. David, and is also a
continuation-in-part of U.S. application Ser. No. 08/538,387, filed Oct.
3, 1995, entitled "REMOTELY PROGRAMMABLE MATRICES WITH MEMORIES", by
Michael P. Nova, Andrew E. Senyei, and Gary S. David, now U.S. Pat. No.
5,874,214.
This application is also a continuation-in-part of each of U.S. application
Ser. Nos. 08/428,662 filed Apr. 25, 1995, now issued as U.S. Pat. No.
5,741,462, 08/480,147 filed Jun. 7, 1995, 08/484,486, filed Jun. 7, 1995,
08/484,504 filed Jun. 7, 1995, now issued as U.S. Pat. No. 5,751,629,
08/480,196 filed Jun. 6, 1995, and 08/473,660 filed Jun. 6, 1995.
U.S. application Ser. Nos. 08/669,252 and 08/633,410 are each a
continuation in-part of International PCT application No. PCT/US96/06145,
which in turn is a continuation-in-part of U.S. application Ser. No.
08/639,813, which application is a continuation-in-part of U.S.
application Ser. No. 08/567,746, which application is a
continuation-in-part of U.S. application Ser. No. 08/538,387, filed Oct.
3, 1995, which in turn is a continuation-in-part of U.S. application Ser.
Nos. 08/480,147, 08/484,486, 08/484,504 now issued as U.S. Pat. No.
5,751,629, 08/480,196 and 08/473,660, each filed Jun. 7, 1995, and each
entitled, "REMOTELY PROGRAMMABLE MATRICES WITH MEMORIES". U.S. application
Ser. No. 08/669,252, is a continuation-in-part of 08/633,410.
Each of U.S. application Ser. Nos. 08/709,435, and 08/711,426 is a
continuation-in-part of International PCT application No. PCT/US96/06145,
and U.S. application Ser. No. 08/709,435, is a continuation-in-part of
U.S. application Ser. No. 08/711,426, now abandoned International PCT
application No. PCT/US96/06145 is a continuation-in-part of U.S.
application Ser. No. 08/538,387. U.S. application Ser. No. 08/538,387 is a
continuation-in-part of U.S. application Ser. Nos. 08/480,147, 08/484,486,
08/484,504, now issued as U.S. Pat. Nos. 5,751,629, 08/480,196 and
08/473,660, each filed Jun. 7, 1995, and each entitled, "REMOTELY
PROGRAMMABLE MATRICES WITH MEMORIES", and is also a continuation-in-part
of U.S. application Ser. No. 08/428,662, now issued as U.S. Pat. No.
5,741,462, filed Apr. 25, 1995, entitled "REMOTELY PROGRAMMABLE MATRICES
WITH MEMORIES". Each of U.S. application Ser. Nos. 08/480,147, 08/484,486,
08/484,504, now issued as U.S. Pat. Nos. 5,741,462, 08/480,196 and
08/473,660 is a continuation-in-part of U.S. application Ser. No.
08/428,662, now issued as U.S. Pat. No. 5,741,462.
The subject matter of each of U.S. application Ser. Nos. 08/709,435
08/711,426, 08/633,410, 08/639,813 08/567,746, 08/538,387, 08/480,147,
08/484,486, 08/484,504 now issued as U.S. Pat. Nos. 5,751,629, 08/480,196,
08/473,660 and 08/428,662 now issued as U.S. Pat. No. 5,741,462 and of
International PCT application No. PCT/US96/06145 is incorporated herein by
reference in its entirety. The subject matter of each of U.S. application
Ser. Nos. 08/379,923, now U.S. Pat. No. 5,583,819 and 08/322,644, now U.S.
Pat. No. 5,724,030 also is incorporated herein its entirety. |
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