The invention discloses a method of preventing transmission of viral pathogens between a source of viral pathogens and a target of said viral pathogens comprising positioning between said source and said target a microporous membrane material comprising (1) a thermoplastic polymer or polytetrafluoroethylene and (2) a water- and oil-repellent fluorochemical compound which provides said membrane with oleophobic, hydrophobic and viral barrier properties.
This application is a division of application Ser. No. 08/384,079 filed Feb. 6, 1995, now abandoned, which is is a continuation-in-part of application Ser. No. 08/105,430, filed Aug. 10, 1993, now abandoned, which is a continuation-in-part of application Ser. No. 07/962,416, filed Oct. 16, 1992, now abandoned, which is a continuation-in-part of application Ser. No. 07/779,014 filed Oct. 18, 199, now abandoned.
The invention is based on the discovery that certain membranes, which include side chains or molecular "brushes" having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e.g., for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.
The invention is based on the discovery that certain membranes, which include side chains or molecular "brushes" having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e.g., for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.
Microporous articles formed by thermally induced phase separation from a diluent in combination with a thermoplastic polymer and a fluorochemical additive providing novel fluid repellent articles. Such articles are useful in clothing, barrier membranes, optical films in electronic devices (such as light reflective and dispersive films), and protective garments.
A hydrophilic polymer composition is described comprising thermoplastic of thermoset polymer, and a fluorochemical additive dispersed therein. The hydrophilic composition is useful, for example, in medical and surgical drapes.
Microporous articles formed by thermally induced phase separation from a diluent in combination with a thermoplastic polymer and a fluorochemical additive providing novel fluid repellent articles. Such articles are useful in clothing, barrier membranes, optical films in electronic devices (such as light reflective and dispersive films), and protective garments.
