A dosage form for intranasal and/or inhalation administration of an analgesic having low opioid receptor binding activity to a warm blooded animal, that includes a pharmaceutically effective amount of the analgesic. A preferred analgesic is tramadol, a tramadol and/or a pharmaceutically acceptable salt, metabolite or derivative thereof. Methods of making and using the formulation according to the invention are also provided.
There is provided a composition for the nasal delivery of a cannabinoid which comprises a cannabinoid in a biphasic delivery system or a cannabinoid in a microsphere delivery system.
Compounds of formula I are effective in treating disorders modulated by opiate receptor activity and/or monoamine activity. ##STR1## In formula I, R.sup.1 is selected from alkyl, aryl, alkylaryl, substituted alkyl, substituted aryl, and substituted alkylaryl; R.sup.2 is selected from hydrogen, hydroxy, cyano, haloalkyl, glycosyl, SO.sub.2 R.sup.5, and OR.sup.5 ; R.sup.3 and R.sup.4 are independently selected from hydrogen and lower alkyl, or R.sup.3 and R.sup.4 taken together with nitrogen form a five- or six-membered heterocyclic or substituted heterocyclic ring; and R.sup.5 is selected from alkyl, aryl, alkylaryl, substituted alkyl, substituted aryl, and substituted alkylaryl.
The present invention provides therapeutic formulations for solutions of .DELTA..sup.9 -tetrahydrocannabinol (.DELTA..sup.9 THC) to be delivered by metered dose inhalers. The formulations, which use, non-CFC propellants, provide a stable aerosol-deliverable source of .DELTA..sup.9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.
The present invention provides therapeutic formulations for solutions of .DELTA..sup.9 -tetrahydrocannabinol (.DELTA..sup.9 THC) to be delivered by metered dose inhalers. The formulations, which utilize non-CFC propellants, provide a stable aerosol-deliverable source of .DELTA..sup.9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy; muscle spasticity; pain; anorexia associated with AIDS wasting syndrome; epilepsy; glaucoma; bronchial asthma; and mood disorders.
The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation.
