The treatment of sexual dysfunction in human patients by an oral therapy regimen of administration of apomorphine and sildenafil is disclosed. This treatment optimizes the efficacy of each drug and substantially minimizes the undesirable side effects associated individually therewith. Apomorphine and sildenafil can be co-administered with a combination dosage unit or administered sequentially in separate dosage units, substantially prior to sexual activity. Other erectogenic agents can be administered along with apomorphine and sildenafil.
The libido of adult human female patients is increased by the intrapulmonary delivery of testosterone. A formulation of testosterone is aerosolized and inhaled into a patient's lungs where particles of testosterone deposits on lung tissue and then enter the patient's circulatory system. The patient's testosterone level is enhanced well above baseline levels for a short period and subsides to baseline levels with normal metabolism thereby providing desired short term effects on enhanced libido without undesirable effects of long term enhanced testosterone levels. Additional formulations are provided including formulations for aerosolized delivery of sildenafil citrate which are delivered to male or female patients.
The present invention relates to treatments for erectile dysfunction comprising momentary vacuum therapy alone or with medications. The treatments may be effective when other treatments (PDE-5 inhibitors (e.g., VIAGRA.RTM.); vasodilators (e.g., ALPROSTADIL.RTM.); combination pharmacotherapies (e.g., VIAGRA.RTM. and MUSE); central nervous system-acting agents (e.g., Apomorphine) fail. All treatments use a finding of the present invention that momentary vacuum therapy increases the elasticity of arteries to overcome, to a significant degree, the arterial inelasticity of atherosclerosis, a primary cause of erectile dysfunction. When momentary vacuum therapy is used with VIAGRA.RTM., e.g., the atherosclerosis problem and the chemical message problem are treated simultaneously. Momentary vacuum therapy may be useful in the treatment of peripheral (e.g., arms and legs) artery disease and congestive heart failure.
A polycyclic guanine phosphodiesterase V inhibitor having the formula (I.1) or (II.1), with the variables defined herein, which is useful for treating sexual dysfunction and other physiological disorders: ##STR1## A representative example is: ##STR2##
Noninvasive angioplasty using momentary vacuum therapy (MVT) is applied to treat erectile dysfunction, peripheral artery disease, and deep vein thrombosis. MVT is a noninvasive angioplasty technique which momentarily increases blood pressure to flatten arterial plaque and increase arterial elasticity for peripheral artery disease and deep vein thrombosis. The workload on the heart will be reduced by the flattening of plaque and the increase in elasticity of the peripheral arteries. The reduction in workload may be a treatment for congestive heart failure (heart failure). For treating erectile dysfunction, MVT increases the elasticity of penile arteries but does not flatten penile plaque; when treating erectile dysfunction with MVT, only an increase in arterial elasticity is required.
A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: ##STR1## For example, a representative compound of the invention is: ##STR2##
