The present invention provides a method and composition for treating pruritus, and also psoriasis which includes applying a compound of formula (I) in a suitable formulation to the affected area. Compounds of formula (I) can also be formulated as a vaginal cream to inhibit viruses such as HIV, and possibly prevent the transmission of other sexually transmitted diseases.
In a positioning device, expandable bodies which expand and contract by air pressure are disposed at opposite sides of a movable member in its moving direction, the movable member being able to reciprocate, and a valve device for holding the expandable bodies in their extended states by valve-closing action is provided in an air path device which supplies air from an air supplying device to the expandable bodies. In a massager including this positioning device, the movable member is movably guided in up and down directions by a guide member provided in a back rest of a chair body, and the movable member is provided with a massage element which is projected from a surface of the back rest and is abutted against a body of a person sitting on the chair body. The movable member is moved by supply and discharge of air to and from the air supplying device through the air path device to the expandable bodies provided at the opposite sides of the movable member in its moving direction, and the movement position of the movable member is adjusted by the valve devices of the air path device.
The invention concerns novel substituted 6-benzyl-4-oxopyrimidines and pharmaceutically acceptable salts thereof. These compounds inhibit reverse transcriptase encoded by human immunodeficiency virus (HIV), and are useful to prevent and treat HIV infection and acquired immune deficiency syndrome (AIDS). Pharmaceutical compositions containing the compounds and a method of use of the present compounds and other agents for the treatment of AIDS and viral infection by HIV are also envisaged.
A method for inhibiting sexual transmission of HIV comprising topically applying to the skin or epithelial tissue of a human a composition comprising a non-nucleoside reverse transcriptase inhibitor ("NNRTI") that is able to inhibit viral replication for periods exceeding 12, 24, or even 36 days, at concentrations below even 10 .mu.M. In one embodiment the NNRTI is a dihydro-alkyloxy-benzyl-oxopyrimidine (DABO).
The invention concerns novel molecules, their preparation and their uses, in particular in the field of human and veterinary medicine and cosmetics. The inventive compounds are partly fatty acid derivatives and exhibit advantageous pharmacological and cosmetic properties. The invention also concerns various uses of said compounds, the pharmaceutical compositions containing them and methods for preparing them. The inventive compounds are useful in particular for preventing and/or treating dyslipidemiae, cardiovascular diseases, syndrome X, restenosis, diabetes, obesity, hypertension, certain cancers, dermatological diseases and in cosmetics, for fighting against skin aging and its effects notably against wrinkles and the like.
A method of treatment for a mammal in need of analgesia from an itching skin comprising applying by directional friction against the skin proximate to the itch a composition consisting essentially of dry elemental iodine in the form of an amorphous condensate. The method is found effective in producing analgesia to the affected skin within 1 to 5 minutes after application.
