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Implantable therapy systems and methods    
United States Patent6179826   
Link to this pagehttp://www.wikipatents.com/6179826.html
Inventor(s)Aebischer; Patrick (Barrington, RI), Goddard; Moses (Tiverton, RI), Moldauer; John G. (Brooklyn, NY), Mulhauser; Paul J. (New York, NY), Rathbun; Anne M. (Providence, RI), Sanberg; Paul R. (Greeenwich, RI), Vasconcellos; Alfred V. (Cranston, RI), Warner; Nicholas F. (Belmont, MA)
AbstractImplantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a dibilatating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) or dilator (104) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. In some instances, the cannula can be inserted along the path of a guidewire (102) previously positioned at the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30) or dilator (104), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A pusher can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the proximal tip of the cannula (20b). Once the vehicle (40) is positioned near the proximal end of the cannula (20), the cannula is removed from the passageway, followed by the pusher, leaving the vehicle (40) positioned at the treatment site (12).
   














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Drawing from US Patent 6179826
Implantable therapy systems and methods - US Patent 6179826 Drawing
Implantable therapy systems and methods
Inventor     Aebischer; Patrick (Barrington, RI) , Goddard; Moses (Tiverton, RI) , Moldauer; John G. (Brooklyn, NY) , Mulhauser; Paul J. (New York, NY) , Rathbun; Anne M. (Providence, RI) , Sanberg; Paul R. (Greeenwich, RI) , Vasconcellos; Alfred V. (Cranston, RI) , Warner; Nicholas F. (Belmont, MA)
Owner/Assignee     Brown University Research Foundation (Providence, RI)
Patent assignment
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Publication Date     January 30, 2001
Application Number     08/741,228
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     October 29, 1996
US Classification     604/522 424/570 604/93.01
Int'l Classification    
Examiner     Bockelman; Mark
Assistant Examiner    
Attorney/Law Firm     Elrifi; Ivor R. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. Prince; John T.
Address
Parent Case     CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation of prior application Ser. No. 08/593,256, filed Jan. 29, 1996 now abandoned which is a division of application Ser. No. 08/459,815, filed Jun. 6, 1995 entitled Implantable Therapy Systems and Methods now U.S. Pat. No. 5,487,739, which is a continuation of prior application Ser. No. 07/998,368, filed Dec. 30, 1992, now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 07/722,947 filed Jun. 28, 1991, entitled "Neural Implant Method and System" now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 07/369,296 filed Jun. 21, 1989, entitled "Neurological Therapy Devices " now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 07/121,626, filed Nov. 17, 1987, entitled "In Vivo Delivery of Neurotransmitters by Implanted, Encapsulated Cells", now U.S. Pat. No. 4,892,538.
Priority Data    
USPTO Field of Search     604/891.1 604/522 604/93.01 424/422 424/424 424/425 424/570
Patent Tags     implantable therapy methods
   
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