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Composition with sustained release of active principle, capable of forming a microemulsion
   
Document Number
US Patent 6309665
Issued Date
October 30, 2001
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Abstract
The invention concerns a composition comprising a microemulsion forming system by contact with a hydrophilic phase brought, after ingestion, by the physiological fluid, said microemulsion forming system comprising: at least an active principle; a lipophilic phase; a surfactant (TA); a co-surfactant (CoTA). The invention is characterized in that said composition further comprises an inert polymeric matrix which cannot be ionised at physiological pH, dispersed in the microemulsion forming system before ingestion, said polymeric matrix being capable, after ingestion, of forming on contacting the physiological fluid, a gelled polymeric matrix enabling to release by diffusion, in continuous and prolonged manner the already micro-emulsified active principle.
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Number of Claims:
20
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Owner
Gattefosse S.A. (Saint Priest,FR)
Published
October 30, 2001
Application Number
09/775,782
Filed
February 2, 2001
US Classification
424/455   424/484 424/487 424/488
Int'l Classification
A61K   9/48   (20060101)   A61K   9/107   (20060101)  
Examiner
Assistant Examiner
Parent Case
CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of copending PCT application PCT/FR 99/10889, filed Jul. 30, 1999, designating the United States and claiming priority from French application 98.10313, filed Aug. 7, 1998. The priorities of both applications are claimed herein, and the entire disclosures of both are incorporated herein by reference.
Priority Data
Aug 07, 1998 [FR] 98 10313
USPTO Field of Search
424/400   424/451   424/455   424/456   424/457   424/463   514/937   514/938   514/944   514/962   514/963   514/964   514/965  
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