This application claims the benefit of priority application Ser. No. 60/113,968, filed on Dec. 28, 1998, which is hereby expressly incorporated by reference.
Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with the microparticle and the identity of the probe, and any target bound to the probe.
The present invention provides methods and devices for making new and inexpensive miniarrays suitable for gene expression analysis. Also provided herein are methods of diagnosis for specific tissue or condition using specialized diagnostic miniarrays that exhibit specific visual pattern as diagnostic readout.
Disclosed are methods of attaching biologically active compounds to a solid surface, comprising modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety.
Apparatus calibrates a micro-array receiver. The apparatus includes a micro-array receiver including a substrate having coated a biologically active region with a composition including a first set of micro-spheres modified with a biological probe and containing an optical bar code generated from at least one colorant associated with the micro-spheres; and a calibration region associated with the substrate, the region being outside the biologically active region and having an area containing the optical bar code color.
