Disclosed are novel aryl-N-alkylnitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals and as analytical reagents for detecting free radicals.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Application No. 60/062,324, filed Oct. 17, 1997; U.S. Provisional Application No. 60/063,736, filed Oct. 29, 1997; and U.S. Provisional Application No. 60/090,475, filed Jun. 24, 1998. These applications are incorporated herein by reference in their entirety.
3,4,5-trisubstituted aryl nitrone compounds having the formula: ##STR1## where R.sup.1 -R.sup.4 are as defined in the specification are useful as therapeutics for neuropathic pain conditions in mammals.
