An agent and method for the prevention and treatment of toxicity caused by heavy metals such as depleted uranium, tungsten and nickel and metals such as iron, lead and copper. The agent is a chelating agent such as picolinic acid or derivatives thereof. The agent chelates and inactivates the metals which can be carcinogenic or poisonous. The agent can be administered to chelate excessive copper as a result of Wilson's disease. The agent can be administered orally or by other systemic routes such as injections and the like.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of application Ser. No. 09/657,554, filed Sep. 8, 2000 and a continuation-in-part of application Ser. No. 09/657,989 filed Sep. 8, 2000, both of which are continuations-in-part of application Ser. No. 09/127,620, filed Aug. 1, 1998, now U.S. Pat. No. 6,127,393 and claims the benefit of No. 60/182,608 filed Feb. 15, 2000.
The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.
The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals or molecules are isolated from a starting material using the modified solid supports of the invention. Also provided by the invention are kits that can be used in connection with the inventive methods.
The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.
The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.
