Methods of preparing 1-substituted, 2-substituted 1H-imidazo [4-5c]-quinolin-4-amines are disclosed. The compounds function as antiviral agents, they induce the biosynthesis of various cytokines including interferon, and they inhibit tumor formation in animal models.
This is a continuation of application Ser. No. 09/386,486, filed on Aug. 27, 1999, now U.S. Pat. No. 6,348,462 which is a division of application Ser. No. 09/060,010, filed on Apr. 14, 1998, now U.S. Pat. No. 5,977,366, which is a division of application Ser. No. 08/789,264, filed Jan. 28, 1997, now U.S. Pat. No. 5,741,909, which is a division of application Ser. No. 08/353,802, filed Dec. 12, 1994, now U.S. Pat. No. 5,605,899, which is a division of application Ser. No. 07/938,295, filed Aug. 28, 1992, now U.S. Pat. No. 5,389,640.
This application is a continuation-in-part of commonly assigned application U.S. Ser. No. 07/838,475, filed Feb. 19, 1992, now abandoned, which is a continuation-in-part of commonly assigned application U.S. Ser. No. 07/687,326, filed Apr. 18, 1991, now abandoned, which is a continuation-in-part of commonly-assigned application U.S. Ser. No. 07/662,926, filed on Mar. 1, 1991, now abandoned.
Methods of preparing 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce the biosynthesis of various cytokines including interferon, and they inhibit tumor formation in animal models.
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