Use of a compound of formula I ##STR1## wherein R.sub.1 is an optionally substituted straight- or branched carbon chain having 12 to 22 carbon atoms which may be optionally interrupted by an optionally substituted phenylene, and each of R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently, is H or lower alkyl, in free form or in pharmaceutically acceptable salt form, in the prevention or treatment of chronic rejection in a recipient of organ or tissue allo- or xenotransplant, or of acute rejection in a xenograft transplant recipient.
This application is a continuation of application Ser. No. 09/308,098, filed May 17, 1999, now U.S. Pat. No. 6,274,629 B1, which is a 371 of PCT/EP97/06408, filed Nov. 17, 1997.
A pro-drug comprising a cyclic undecapeptide wherein the peptide chain thereof comprises at least one amino acid residue, useful as a medicinal product, including use for treatment of pathological conditions of the eye.
