Methods for assessing the risk of developing Type 2 diabetes and other related disorders include obtaining an NMR derived reference spectrum for a known glucose concentration sample and storing this information as a reference standard. A patient blood sample is collected and NMR derived patient spectrums for the blood sample are obtained. The two NMR data sets (the reference and the patient) are compared and a glucose concentration is determined for the patient sample. The glucose concentration can be evaluated with a blood sample undergoing lipoprotein cholesterol evaluation. The NMR based test can be used to concurrently provide a glucose concentration and lipoprotein constituent values based on a single testing event. The disclosure also includes a multi-purpose test, i.e., a test which concurrently provides lipoprotein screening and coronary heart disease risk evaluation along with a diabetes screening and risk assessment for developing Type 2 diabetes. A method for assessing diabetes includes identifying the presence of diabetic dyslipidemia based on the values of predetermined NMR measured lipoprotein constituents.
A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.
Methods, systems and computer programs are configured to determine the presence of and/or a measurement for a plurality of constituents in a composite signal with closely correlated chemical constituents having overlapping signal lineshapes extending about a spectrum of interest obtained from a target sample undergoing analysis.
Processing electronic documents includes retrieving a first electronic document located in a reference directory specified by a first path and searching for a second electronic document purported to be specified by a second path. If the second electronic document is not located at the second path, continue searching in a directory higher than the reference directory.
The invention relates to a risk based testing method. The risk based testing method comprises defining a process or system to be tested, identifying a plurality of risks associated with the process or system, quantifying each of the risks with a risk value, defining a test plan for the process or system, the test plan including a number of test cases, wherein testing of the test cases is prioritized based on the risk value, and executing the test plan. The invention also relates an article of manufacture. The article of manufacture comprises a computer useable medium having computer readable program code means embodied therein for testing a process or a system. The computer readable program code means in the article of manufacture comprises: computer readable program code means for causing the computer to receive and store data identifying a plurality of risks associated with the process or system; computer readable program code means for causing the computer to receive and store a risk value associated with each of the plurality of risks; computer readable program code means for causing the computer to receive and store data defining a test plan for the process or system, the test plan including at least one test case, the at least one test case comprising at least one step; computer readable program code means for causing the computer to receive and store data associating each of the plurality of risks with a step of a test case; and computer readable program code means for causing the computer to generate a report listing the risks in order of the risk value.