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Cyanohydrin ethers and esters as high-sensitivity enzyme substrates
 
   
Document Number
US Patent 6528675
Issued Date
March 4, 2003
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Abstract
Ethers and esters of cyanohydrins that contain optically detectable moieties are highly effective for detecting, monitoring, and measuring the activity of enzymes that cause the cleavage of certain types of substrates. The cyanohydrins function as proaldehydes and proketones, spontaneously converting to aldehydes and ketones, respectively, which provide a large increase in optical detectability relative to both the starting esters and ethers and the cyanohydrins.
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Number of Claims:
20
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Published
March 4, 2003
Application Number
09/971,105
Filed
October 3, 2001
US Classification
558/407   558/406
Int'l Classification
C07C   271/24   (20060101)   C07C   271/00   (20060101)   C07C   255/00   (20060101)   C07C   255/37   (20060101)   C07C   255/38   (20060101)   C07C   255/39   (20060101)   C07D   295/155   (20060101)   C07D   303/40   (20060101)   C07D   295/00   (20060101)   C07D   303/00   (20060101)   C07K   5/087   (20060101)   C07K   5/00   (20060101)  
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USPTO Field of Search
558/407   558/406  
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