1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be useful for preventing or treating diabetes, preventing or treating hyperlipidemia, preventing or treating impaired glucose tolerance (IGT) or for preventing transition from impaired glucose tolerance to diabetes.
The present invention relates to compounds of formula (I): wherein R.sub.1 is hydroxy, C.sub.1-4 alkoxy, amino, C.sub.1-4 alkyl-amino, di C.sub.1-4alkylamino, benzyloxy or C.sub.2-C.sub.7 alkanoyl, R.sub.2 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy C.sub.1-4alkoxy, CF.sub.3, halogen, C.sub.1-4alkylamino, di C.sub.1-4alkylamino, di C.sub.1-4 alkylamino C.sub.1-4 alkoxy or N--C.sub.1-4 alkoxy C.sub.1-4 alkyl-N--C.sub.1-4 alkylamino, N--C.sub.1-4 alkyl-piperazinyl, morpholinyl or pyrrolidinyl-C.sub.1-4 alkoxy, wherein the C.sub.1-4 alkyl radicals in R.sub.2 are optionally further substituted by C.sub.1-4 alkyl, halogen, cyano, amino, alkoxy or alkylthio, X is N or O, Y is N, O or CH, Z is N or CH, and W is N or CH, provided that (a) R.sub.1 is not hydroxy or C.sub.1-4 alkoxy when R.sub.2 is CF.sub.3, X is O, Y is CH, Z is N and W is CH, (b) R.sub.1 is not hydroxy or C.sub.1-4 alkoxy when R.sub.2 is CF.sub.3 or chloro, X is N, Y is O, Z is CH and W is CH, (c) R.sub.1 is not hydroxy when R.sub.2 is CF.sub.3, X is O, Y is N, Z is CH and W is CH and (d) X and Y are not simultaneously O, the salts thereof; their preparation, their use and pharmaceutical compositions containing them. ##STR00001##
Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticalsThe invention relates to diarylcycloalkyl derivatives and to their physiologically acceptable salts, racemates and physiologically functional derivatives.What is described are compounds of the formula I, ##STR00001## in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
The present invention relates to compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, use as Raf Kinase Inhibitors and treatment methods for neurotraumatic diseases and cancer.
