May 20, 2003

In accordance with the present invention there is provided a method for treating or preventing a Flaviviridea viral infection in a host comprising administering a therapeutically effective amount of at least one compound of formula (I) or (II) ##STR1## or a pharmaceutically acceptable salts thereof, wherein Ra, R, Z and Y are defined in the application.

66

May 20, 2003

09/704,832

November 3, 2000

514/81   514/241 514/245 514/246 514/263.23 514/385 514/393

A61K   45/06   (20060101)   A61K   31/52   (20060101)   A61K   31/505   (20060101)   A61K   38/20   (20060101)   A61K   45/00   (20060101)   A61K   38/21   (20060101)   A61K   31/415   (20060101)   A61K   31/519   (20060101)   A61K   31/53   (20060101)  

This application claims priority from Serial No. Application 60/163,405 and Serial No. Application 60/163,394 filed Nov. 4 1999 which are herein incorporated by reference.

514/261   514/262   514/385   514/393   514/241   514/245   514/246  

	6784166 - 4'-substituted nucleoside derivatives as inhibitors of HCV RNA replication. - Owned by Syntex (U.S.A.) LLC (Palo Alto, CA) The present invention relates to the use of nucleoside derivatives of formula I ##STR1## wherein B signifies a 9-purinyl residue B1 of formula ##STR2## or a 1-pyrimidyl residue B2 of formula ##STR3## wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
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