Kits containing the diagnostic systems and diagnostic systems that rely on bioluminescence for visualizing tissues in situ are provided. The systems include compositions containing conjugates that include a tissue specific, particularly a tumor-specific, targeting agent linked to a targeted agent, a luciferase or luciferin. The systems also include a second composition that contains the remaining components of a bioluminescence generating reaction. Administration of the compositions results production of light by targeted tissues that permits the detection and localization of neoplastic tissue for surgical removal.
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of U.S. Ser. No. 08/908,909 filed Aug. 8, 1997 to Bruce Bryan, entitled "DETECTION AND VISUALIZATION OF NEOPLASTIC TISSUES AND OTHER TISSUES" now U.S. Pat. No. 6,416,960. This application and U.S. application Ser. No. 08/908,909 claim the benefit of priority under 35 U.S.C. .sctn.119(e) to U.S. provisional application Ser. No. 60/023,374 to Bruce Bryan, filed Aug. 8, 1996, and entitled DETECTION AND VISUALIZATION OF NEOPLASMS AND OTHER TISSUES.
RELATED APPLICATIONS
Subject matter in this application is related to subject matter in allowed U.S. application Ser. No. 08/597,274 to Bruce Bryan, filed Feb. 6, 1996, entitled "BIOLUMINESCENT NOVELTY ITEMS", and U.S. application Ser. No. 08/757,046 to Bruce Bryan, filed Nov. 25, 1996, now U.S. Pat. No. 5,876,995, entitled "BIOLUMINESCENT NOVELTY ITEMS". The subject matter of each of U.S. application Ser. No. 08/597,274 and U.S. application Ser. No. 08/757,046, and U.S. provisional application Serial No. 60/023,374 is herein incorporated in its entirety by reference thereto.
