A knockout mouse in which the Fgl-2 gene has been suppressed is described. The mouse is useful in studying the role of Fgl-2 in normal and disease states including viral hepatitis, allograph rejection, fetal loss, inflammatory bowel disease, lupus glomerulonephritis; acute respiratory disease syndrome, Whipple's disease, cancer and for developing therapies to treat these diseases.
The present application is a continuation-in-part of U.S. application Ser. No. 09/442,143, filed on Nov. 15, 1999 now U.S. Pat. No. 6,403,089, which is a continuation of PCT/CA98/00475, filed on May 15, 1998, which claims the benefit of U.S. provisional patent application No. 60/061,684, filed on Oct. 10, 1997 and U.S. provisional patent application No. 60/046,537, filed on May 15, 1997, all of which are incorporated herein by reference in their entirety.
